KEGG   DRUG: Bempikibart
Entry
D12739                      Drug                                   
Name
Bempikibart (USAN/INN)
Formula
C6580H10172N1744O2100S42
Exact mass
148565.1050
Mol weight
148656.40
Sequence
(Heavy chain)
EVQLVESGGG LVQPGRSLRL SCAASGFTFD DHAMHWVRQA PGKGLEWVSG ISWNSRGIGY
ADSVKGRFTI FRDNAKNSLY LQMNSLRAED TALYYCAKDE YSRGYYVLDV WGQGTTVTVS
SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP SNTKVDKRVE PKSCDKTHTC PPCPAPEAEG
APSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY
NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRE
EMTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG
(Light chain)
AIQLTQSPSS LSASVGDRVT ITCRASQGIS SALAWYQQKP GKAPKLLIYD ASSLESGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ FNSYPLWITF GQGTRLEIKR TVAAPSVFIF
PPSDEQLKSG TASVVCLLNN FYPREAKVQW KVDNALQSGN SQESVTEQDS KDSTYSLSST
LTLSKADYEK HKVYACEVTH QGLSSPVTKS FNRGEC
(Disulfide brige: H22-H96, H148-H204, H224-L216, H230-H'230, H233-H'233, H265-H325, H371-H429, H'22-H'96, H'148-H'204, H'224-L'216, H'265-H'325, H'371-H'429, L23-L88, L136-L196, L'23-L'88, L'136-L'196)
  Type
Peptide
Efficacy
Autoimmune disease treatment
  Type
Monoclonal antibody
Comment
Treatment of autoimmune disorders
Target
IL7R (CD127) [HSA:3575] [KO:K05072]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Interleukin receptors
    IL7R (CD127)
     D12739  Bempikibart (USAN/INN)
Other DBs
CAS: 2622254-57-1
PubChem: 497621152
LinkDB

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