Entry |
|
Name |
Lorundrostat (USAN/INN) |
Formula |
C24H33N7O2
|
Exact mass |
451.2696
|
Mol weight |
451.56
|
Structure |
![](/Fig/drug/D12773.gif)
|
Remark |
|
Efficacy |
Antihypertensive, Aldosterone synthase inhibitor |
Comment |
Treatment of aldosterone dependent cardiorenal conditions such as hypertension, chronic kidney disease and congestive heart failure
|
Target |
|
Pathway |
hsa04925 | Aldosterone synthesis and secretion |
|
Brite |
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Cytochrome P450
CYP11B2
D12773 Lorundrostat (USAN/INN)
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 33
1 C8x C 7.1400 -16.8700
2 C8y C 7.1400 -18.2700
3 C8x C 8.3300 -18.9700
4 C8x C 9.5900 -18.2700
5 C8y C 9.5900 -16.8700
6 C8x C 8.3300 -16.1700
7 C8y C 10.7800 -16.1700
8 C1a C 5.9500 -18.9700
9 N5x N 11.9700 -16.8700
10 C8y C 13.2300 -16.1700
11 N5x N 13.2300 -14.7700
12 N5x N 12.0400 -14.0700
13 C8x C 10.7800 -14.7700
14 N1y N 14.4200 -16.8700
15 C1x C 14.4200 -18.2700
16 C1x C 15.6800 -18.9700
17 N1y N 16.8700 -18.2700
18 C1x C 16.8700 -16.8700
19 C1x C 15.6800 -16.1700
20 C1b C 18.0600 -18.9700
21 C5a C 19.2500 -18.2700
22 N1b N 20.4400 -18.9700
23 O5a O 19.2500 -16.8700
24 C1y C 21.6300 -18.2700
25 C1x C 22.8200 -18.9700
26 C1x C 24.0800 -18.2700
27 C1y C 24.0800 -16.8700
28 C1x C 22.8900 -16.1700
29 C1x C 21.6300 -16.8700
30 N1b N 25.2700 -16.1700
31 C5a C 26.4600 -16.8700
32 C1a C 27.6500 -16.1700
33 O5a O 26.4600 -18.2700
BOND 36
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 2 8 1
9 7 9 1
10 9 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 7 13 2
15 10 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 14 19 1
22 17 20 1
23 20 21 1
24 21 22 1
25 21 23 2
26 24 22 1 #Down
27 24 25 1
28 25 26 1
29 26 27 1
30 27 28 1
31 28 29 1
32 24 29 1
33 27 30 1 #Up
34 30 31 1
35 31 32 1
36 31 33 2
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