| Entry |
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| Symbol |
CYP11B2
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| Name |
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| Pathway |
| map04925 | Aldosterone synthesis and secretion |
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| Module |
| M00108 | C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone |
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| Reaction |
| R02218 | progesterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating) |
| R02725 | androstenedione,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating) |
| R02843 | steroid,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating) |
| R03262 | corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating) |
| R03329 | steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating) |
| R03851 | 11-deoxycorticosterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating) |
| R04850 | 17alpha,21-dihydroxypregnenolone:oxygen oxidoreductase (11-hydroxylating) |
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| Disease |
| H00258 | Aldosterone synthase deficiency |
| H00602 | Glucocorticoid-remediable aldosteronism (GRA) |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
K07433 CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
09150 Organismal Systems
09152 Endocrine system
04925 Aldosterone synthesis and secretion
K07433 CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450
K07433 CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.15.4 steroid 11beta-monooxygenase
K07433 CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
1.14.15.5 corticosterone 18-monooxygenase
K07433 CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
CYP11 family
K07433 CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
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| Other DBs |
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| Genes |
» show all
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| Reference |
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| Authors |
Mornet E, Dupont J, Vitek A, White PC |
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| Title |
Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta). |
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| Journal |
J Biol Chem 264:20961-7 (1989) |
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| Sequence |
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| Reference |
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| Authors |
Bureik M, Lisurek M, Bernhardt R |
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| Title |
The human steroid hydroxylases CYP1B1 and CYP11B2. |
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| Journal |
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| LinkDB |
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