| Entry |
|
|---|
| Name |
Lorundrostat hydrobromide (USAN) |
|---|
| Formula |
C24H33N7O2. HBr
|
|---|
| Exact mass |
531.1957
|
|---|
| Mol weight |
532.48
|
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| Structure |
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihypertensive, Aldosterone synthase inhibitor |
|---|
| Comment |
Treatment of aldosterone dependent cardiorenal conditions such as hypertension, chronic kidney disease and congestive heart failure
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04925 | Aldosterone synthesis and secretion |
|
|---|
| Brite |
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Cytochrome P450
CYP11B2
D12774 Lorundrostat hydrobromide (USAN)
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 34
1 C8x C 8.9632 -16.3158
2 C8y C 8.9632 -17.7163
3 C8x C 10.1536 -18.4165
4 C8x C 11.4140 -17.7163
5 C8y C 11.4140 -16.3158
6 C8x C 10.1536 -15.6155
7 C8y C 12.6045 -15.6155
8 C1a C 7.7727 -18.4165
9 N5x N 13.7949 -16.3158
10 C8y C 15.0553 -15.6155
11 N5x N 15.0553 -14.2150
12 N5x N 13.8649 -13.5148
13 C8x C 12.6045 -14.2150
14 N1y N 16.2457 -16.3158
15 C1x C 16.2457 -17.7163
16 C1x C 17.5062 -18.4165
17 N1y N 18.6966 -17.7163
18 C1x C 18.6966 -16.3158
19 C1x C 17.5062 -15.6155
20 C1b C 19.8870 -18.4165
21 C5a C 21.0774 -17.7163
22 N1b N 22.2679 -18.4165
23 O5a O 21.0774 -16.3158
24 C1y C 23.4583 -17.7163
25 C1x C 24.6487 -18.4165
26 C1x C 25.9092 -17.7163
27 C1y C 25.9092 -16.3158
28 C1x C 24.7187 -15.6155
29 C1x C 23.4583 -16.3158
30 N1b N 27.0996 -15.6155
31 C5a C 28.2900 -16.3158
32 C1a C 29.4804 -15.6155
33 O5a O 28.2900 -17.7163
34 X Br 21.2100 -13.0900
BOND 36
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 2 8 1
9 7 9 1
10 9 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 7 13 2
15 10 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 14 19 1
22 17 20 1
23 20 21 1
24 21 22 1
25 21 23 2
26 24 22 1 #Down
27 24 25 1
28 25 26 1
29 26 27 1
30 27 28 1
31 28 29 1
32 24 29 1
33 27 30 1 #Up
34 30 31 1
35 31 32 1
36 31 33 2
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