KEGG   DRUG: Casdozokitug
Entry
D12784                      Drug                                   
Name
Casdozokitug (USAN/INN)
Formula
C6536H10104N1756O2046S42
Exact mass
147272.8844
Mol weight
147363.4286
Sequence
(Heavy chain)
EVQLVESGGG LVKPGGSLRL SCAASGFTFR SYGMNWVRQA PGKGLEWVSG ISSSGSYIYY
ADSVKGRFTI SRDNAKNSLY LQMNSLRAED TAVYYCARDG GRTSYTATAH NWFDPWGQGT
LVTVSSASTK GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP
AVLQSSGLYS LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTCPPCPA
PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP
REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL
PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT
VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
(Light chain)
DIVMTQSPDS LAVSLGERAT INCKSSQSVL FSSNNKNYLA WYQQKPGQPP KLLIYWASTR
ESGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCQQHASA PPTFGGGTKV EIKRTVAAPS
VFIFPPSDEQ LKSGTASVVC LLNNFYPREA KVQWKVDNAL QSGNSQESVT EQDSKDSTYS
LSSTLTLSKA DYEKHKVYAC EVTHQGLSSP VTKSFNRGEC
(Disulfide bridge: H22-H96, H153-H209, H229-L220, H235-H'235, H238-H'238, H270-H330, H376-H434, H'22-H'96, H'153-H'209, H'229-L'220, H'270-H'330, H'376-H'434, L23-L94, L140-L200, L'23-L'94, L'140-L'200)
  Type
Peptide
Efficacy
Antineoplastic
Target
IL27 [HSA:246778] [KO:K22629]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
hsa04659  Th17 cell differentiation
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interleukins
    IL27
     D12784  Casdozokitug (USAN/INN)
Other DBs
CAS: 2643331-37-5
LinkDB

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