KEGG   DRUG: Ivonescimab
Entry
D12808                      Drug                                   
Name
Ivonescimab (USAN/INN)
Formula
C8908H13600N2392O2812S60
Exact mass
200993.7976
Mol weight
201117.64
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGYTFT NYGMNWVRQA PGKGLEWVGW INTYTGEPTY
AADFKRRFTF SLDTSKSTAY LQMNSLRAED TAVYYCAKYP HYYGSSHWYF DVWGQGTLVT
VSSASTKGPS VFPLAPSSKS TSGGTAALGC LVKDYFPEPV TVSWNSGALT SGVHTFPAVL
QSSGLYSLSS VVTVPSSSLG TQTYICNVNH KPSNTKVDKK VEPKSCDKTH TCPPCPAPEA
AGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE
QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS
RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK
SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGKGGGGSGG GGSGGGGSGG GGSEVQLVES
GGGLVQPGGS LRLSCAASGF AFSSYDMSWV RQAPGKGLDW VATISGGGRY TYYPDSVKGR
FTISRDNSKN NLYLQMNSLR AEDTALYYCA NRYGEAWFAY WGQGTLVTVS SGGGGSGGGG
SGGGGSGGGG SDIQMTQSPS SMSASVGDRV TFTCRASQDI NTYLSWFQQK PGKSPKTLIY
RANRLVSGVP SRFSGSGSGQ DYTLTISSLQ PEDMATYYCL QYDEFPLTFG AGTKLELKR
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCSASQDIS NYLNWYQQKP GKAPKVLIYF TSSLHSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YSTVPWTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H150-H206, H226-L214, H232-H'232, H235-H'235, H267-H327, H373-H431, H495-H569, H634-H699, H'22-H'96, H'150-H'206, H'226-L'214, H'267-H'327, H'373-H'431, H7495-H'569, H'634-H'699, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antineoplastic
  Type
Monoclonal antibody, bispecific antibody
Comment
Treatment of various solid tumors
Target
VEGFA [HSA:7422] [KO:K05448]
PDCD1 (PD1, CD279) [HSA:5133] [KO:K06744]
  Pathway
hsa04014  Ras signaling pathway
hsa04370  VEGF signaling pathway
hsa04660  T cell receptor signaling pathway
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Growth factors (RTK-binding)
    VEGFA
     D12808  Ivonescimab (USAN/INN)
 Cell surface molecules and ligands
  Other cell surface molecules
   Immune checkpoints
    PDCD1 (PD1, CD279)
     D12808  Ivonescimab (USAN/INN)
Other DBs
CAS: 2428381-53-5
PubChem: 497621221
LinkDB

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