KEGG   DRUG: Suzetrigine
Entry
D12860                      Drug                                   
Name
Suzetrigine (USAN/INN);
Journavx (TN)
Product
JOURNAVX (Vertex Pharmaceuticals Incorporated)
Formula
C21H20F5N3O4
Exact mass
473.1374
Mol weight
473.39
Structure
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Product: D12860<US>
Efficacy
Analgesic, Selective sodium channel blocker
Comment
Treatment of acute and neuropathic pain
Target
SCN10A [HSA:6336] [KO:K04842]
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Brite
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D12860  Suzetrigine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN10A
     D12860  Suzetrigine (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12860
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12860
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12860
Other DBs
CAS: 2649467-58-1
PubChem: 497621273
ChEBI: 233446
LinkDB
KCF data

ATOM        33
            1   C8y C    19.4600  -12.4600
            2   C8x C    19.4600  -13.8600
            3   C8x C    20.6724  -14.5600
            4   N5x N    21.8849  -13.8600
            5   C8y C    21.8849  -12.4600
            6   C8x C    20.6724  -11.7600
            7   C5a C    23.1160  -11.7490
            8   N1a N    24.3212  -12.4447
            9   O5a O    23.1157  -10.3601
            10  N1b N    18.2476  -11.7600
            11  C5a C    17.0521  -12.4504
            12  C1y C    15.8647  -11.7649
            13  O5a O    17.0520  -13.8597
            14  O2x O    15.7181  -10.3706
            15  C1z C    14.3467  -10.0792
            16  C1y C    13.6457  -11.2934
            17  C1y C    14.5839  -12.3353
            18  C8y C    14.2949  -13.6947
            19  C8y C    12.9425  -14.1336
            20  C8y C    12.6510  -15.5029
            21  C8y C    13.6911  -16.4400
            22  C8x C    15.0435  -16.0011
            23  C8x C    15.3350  -14.6318
            24  X   F    13.3989  -17.8127
            25  X   F    11.3463  -15.9259
            26  O2a O    11.9097  -13.2031
            27  C1a C    10.5615  -13.6404
            28  C1a C    12.9944   -9.7168
            29  C1d C    15.0467   -8.8667
            30  X   F    15.7467   -7.6543
            31  X   F    13.8343   -8.1667
            32  C1a C    12.2602  -11.4390
            33  X   F    16.4467   -8.8667
BOND        35
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     7   9 2
            10    1  10 1
            11   10  11 1
            12   12  11 1 #Up
            13   11  13 2
            14   12  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   12  17 1
            19   17  18 1 #Down
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1
            26   21  24 1
            27   20  25 1
            28   19  26 1
            29   26  27 1
            30   15  28 1 #Up
            31   15  29 1 #Down
            32   29  30 1
            33   29  31 1
            34   16  32 1 #Down
            35   29  33 1

» Japanese version   » Back

DBGET integrated database retrieval system