KEGG   DRUG: Ripasudil
Entry
D13014                      Drug                                   
Name
Ripasudil (USAN/INN)
Formula
C15H18FN3O2S
Exact mass
323.1104
Mol weight
323.39
Structure
Remark
ATC code: S01EX07
Chemical structure group: DG03329
Product (DG03329): D10463<JP>
Efficacy
Antiglaucoma, Rho-associated kinase inhibitor
Comment
Treatment of Fuchs endothelial corneal dystrophy
Target
ROCK [HSA:6093 9475] [KO:K04514 K17388]
  Pathway
hsa04270  Vascular smooth muscle contraction
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EX Other antiglaucoma preparations
     S01EX07 Ripasudil
      D13014  Ripasudil (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   AGC group
    ROCK
     D13014  Ripasudil (USAN/INN)
Other DBs
CAS: 223645-67-8
PubChem: 505028111
LinkDB
KCF data

ATOM        22
            1   C1x C    16.5066  -14.6870
            2   C1x C    15.6673  -13.5679
            3   C1x C    15.9471  -12.1692
            4   N1x N    17.2759  -11.6097
            5   N1y N    17.9053  -14.6870
            6   C1x C    18.4648  -12.2391
            7   C1y C    18.8145  -13.5679
            8   S4a S    17.9053  -16.0857
            9   C8y C    17.9053  -17.4845
            10  O3c O    19.3041  -16.0857
            11  O3c O    16.5066  -16.0857
            12  C8x C    16.7164  -18.1838
            13  C8x C    16.7164  -19.5826
            14  C8x C    17.9053  -20.2820
            15  C8y C    19.0943  -19.5826
            16  C8y C    19.0943  -18.1838
            17  C8x C    20.3532  -20.2820
            18  N5x N    21.5421  -19.5826
            19  C8x C    21.5421  -18.1838
            20  C8y C    20.3532  -17.4845
            21  C1a C    20.2133  -13.8477
            22  X   F    20.3532  -16.0857
BOND        24
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     5   8 1
            9     8   9 1
            10    8  10 2
            11    8  11 2
            12    9  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17    9  16 1
            18   15  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   16  20 1
            23    7  21 1 #Down
            24   20  22 1

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