KEGG   DRUG: Lerodalcibep
Entry
D13095                      Drug                                   
Name
Lerodalcibep (USAN/INN);
Lerodalcibep-liga;
Lerochol (TN)
Product
LEROCHOL (LIB Therapeutics)
Formula
C3427H5324N908O1045S40
Exact mass
77198.0203
Mol weight
77247.08
Sequence
VSDVPRDLEV VAATPTSLLI SWDAPAEGYG YYRITYGETG GNSPVQEFTV PVSKGTATIS
GLKPGVDYTI TVYAVEFDFP GAGYYHRPIS INYRTEGSGS GSDAHKSEVA HRFKDLGEEN
FKALVLIAFA QYLQQAPFED HVKLVNEVTE FAKTCVADES AENCDKSLHT LFGDKLCTVA
TLRETYGEMA DCCAKQEPER NECFLQHKDD NPNLPRLVRP EVDVMCTAFH DNEETFLKKY
LYEIARRHPY FYAPELLFFA KRYKAAFTEC CQAADKAACL LPKLDELRDE GKASSAKQRL
KCASLQKFGE RAFKAWAVAR LSQRFPKAEF AEVSKLVTDL TKVHTECCHG DLLECADDRA
DLAKYICENQ DSISSKLKEC CEKPLLEKSH CIAEVENDEM PADLPSLAAD FVESKDVCKN
YAEAKDVFLG MFLYEYARRH PDYSVVLLLR LAKTYETTLE KCCAAADPHE CYAKVFDEFK
PLVEEPQNLI KQNCELFEQL GEYKFQNALL VRYTKKVPQV STPTLVEVSR NLGKVGSKCC
KHPEAKRMPC AEDYLSVVLN QLCVLHEKTP VSDRVTKCCT ESLVNRRPCF SALEVDETYV
PKEFNAETFT FHADICTLSE KERQIKKQTA LVELVKHKPK ATKEQLKAVM DDFAAFVEKC
CKADDKETCF AEEGKKLVAA SQAALGL
(Disulfide bridge: 155-164, 177-192, 193-203, 226-270, 271-279, 302-347, 348-355, 367-380, 381-391, 418-462, 463-471, 494-539, 540-550, 563-578, 579-589, 616-660, 661-669)
  Type
Peptide
Class
Hypolipidemic agent
 DG01946  Hypolipidemic agent
  DG03128  Anti-PCSK9 antibody and siRNA
Remark
ATC code: C10AX19
Product: D13095<US>
Efficacy
Antihyperlipidemic
  Disease
Heterozygous familial hypercholesterolemia [DS:H00155]
Hypercholesterolemia [DS:H00155]
  Type
Bioengineered antibody mimetic
Comment
Treatment of hypercholesterolemia
Target
PCSK9 [HSA:255738] [KO:K13050]
  Pathway
hsa04979  Cholesterol metabolism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AX Other lipid modifying agents
     C10AX19 Lerodalcibep
      D13095  Lerodalcibep (USAN/INN) <US>
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG03128  Anti-PCSK9 antibody and siRNA
    D13095  Lerodalcibep
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Subtilisin family
    PCSK9
     D13095  Lerodalcibep (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D13095
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D13095
Other DBs
CAS: 2250073-78-8
PubChem: 508750765
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system