Homo sapiens (human): 255738
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Entry
255738 CDS
T01001
Symbol
PCSK9, FH3, FHCL3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
Name
(RefSeq) proprotein convertase subtilisin/kexin type 9
KO
K13050
proprotein convertase subtilisin/kexin type 9 [EC:3.4.21.-]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04979
Cholesterol metabolism
Network
nt06320
APOB-LDLR signaling
Element
N00336
PCSK9-mediated LDLR degradation
Disease
H00155
Familial hypercholesterolemia
H02505
Atherosclerosis
Drug target
Alirocumab:
D10335
<US>
Bococizumab:
D10621
Evolocumab:
D10557
<JP/US>
Frovocimab:
D11398
Inclisiran (
DG03216
):
D11931
D12293
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09154 Digestive system
04979 Cholesterol metabolism
255738 (PCSK9)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
255738 (PCSK9)
09182 Protein families: genetic information processing
03110 Chaperones and folding catalysts [BR:
hsa03110
]
255738 (PCSK9)
Peptidases and inhibitors [BR:
hsa01002
]
Serine peptidases
Family S8: subtilisin family
255738 (PCSK9)
Chaperones and folding catalysts [BR:
hsa03110
]
Intramolecular chaperones
Subtilisin family
255738 (PCSK9)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PCSK9_C1
PCSK9_C2
PCSK9_C3
Peptidase_S8
Inhibitor_I9
Motif
Other DBs
NCBI-GeneID:
255738
NCBI-ProteinID:
NP_777596
OMIM:
607786
HGNC:
20001
Ensembl:
ENSG00000169174
UniProt:
Q8NBP7
Structure
PDB
LinkDB
All DBs
Position
1:55039548..55064852
Genome browser
AA seq
692 aa
AA seq
DB search
MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGT
TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLP
GFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLV
EVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAG
VAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAA
CQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVD
LFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSA
KDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPD
EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAP
PAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASC
CHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRD
VSTTGSTSEGAVTAVAICCRSRHLAQASQELQ
NT seq
2079 nt
NT seq
+upstream
nt +downstream
nt
atgggcaccgtcagctccaggcggtcctggtggccgctgccactgctgctgctgctgctg
ctgctcctgggtcccgcgggcgcccgtgcgcaggaggacgaggacggcgactacgaggag
ctggtgctagccttgcgttccgaggaggacggcctggccgaagcacccgagcacggaacc
acagccaccttccaccgctgcgccaaggatccgtggaggttgcctggcacctacgtggtg
gtgctgaaggaggagacccacctctcgcagtcagagcgcactgcccgccgcctgcaggcc
caggctgcccgccggggatacctcaccaagatcctgcatgtcttccatggccttcttcct
ggcttcctggtgaagatgagtggcgacctgctggagctggccttgaagttgccccatgtc
gactacatcgaggaggactcctctgtctttgcccagagcatcccgtggaacctggagcgg
attacccctccacggtaccgggcggatgaataccagccccccgacggaggcagcctggtg
gaggtgtatctcctagacaccagcatacagagtgaccaccgggaaatcgagggcagggtc
atggtcaccgacttcgagaatgtgcccgaggaggacgggacccgcttccacagacaggcc
agcaagtgtgacagtcatggcacccacctggcaggggtggtcagcggccgggatgccggc
gtggccaagggtgccagcatgcgcagcctgcgcgtgctcaactgccaagggaagggcacg
gttagcggcaccctcataggcctggagtttattcggaaaagccagctggtccagcctgtg
gggccactggtggtgctgctgcccctggcgggtgggtacagccgcgtcctcaacgccgcc
tgccagcgcctggcgagggctggggtcgtgctggtcaccgctgccggcaacttccgggac
gatgcctgcctctactccccagcctcagctcccgaggtcatcacagttggggccaccaat
gcccaagaccagccggtgaccctggggactttggggaccaactttggccgctgtgtggac
ctctttgccccaggggaggacatcattggtgcctccagcgactgcagcacctgctttgtg
tcacagagtgggacatcacaggctgctgcccacgtggctggcattgcagccatgatgctg
tctgccgagccggagctcaccctggccgagttgaggcagagactgatccacttctctgcc
aaagatgtcatcaatgaggcctggttccctgaggaccagcgggtactgacccccaacctg
gtggccgccctgccccccagcacccatggggcaggttggcagctgttttgcaggactgta
tggtcagcacactcggggcctacacggatggccacagccgtcgcccgctgcgccccagat
gaggagctgctgagctgctccagtttctccaggagtgggaagcggcggggcgagcgcatg
gaggcccaagggggcaagctggtctgccgggcccacaacgcttttgggggtgagggtgtc
tacgccattgccaggtgctgcctgctaccccaggccaactgcagcgtccacacagctcca
ccagctgaggccagcatggggacccgtgtccactgccaccaacagggccacgtcctcaca
ggctgcagctcccactgggaggtggaggaccttggcacccacaagccgcctgtgctgagg
ccacgaggtcagcccaaccagtgcgtgggccacagggaggccagcatccacgcttcctgc
tgccatgccccaggtctggaatgcaaagtcaaggagcatggaatcccggcccctcaggag
caggtgaccgtggcctgcgaggagggctggaccctgactggctgcagtgccctccctggg
acctcccacgtcctgggggcctacgccgtagacaacacgtgtgtagtcaggagccgggac
gtcagcactacaggcagcaccagcgaaggggccgtgacagccgttgccatctgctgccgg
agccggcacctggcgcaggcctcccaggagctccagtga
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