| Entry |
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| Symbol |
PCSK9, FH3, FHCL3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
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| Name |
(RefSeq) proprotein convertase subtilisin/kexin type 9
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| KO |
| K13050 | proprotein convertase subtilisin/kexin type 9 [EC:3.4.21.-] |
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| Organism |
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| Pathway |
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| Network |
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| Element |
| N00336 | PCSK9-mediated LDLR degradation |
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| Disease |
| H00155 | Familial hypercholesterolemia |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
09154 Digestive system
04979 Cholesterol metabolism
255738 (PCSK9)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:hsa01002]
255738 (PCSK9)
09182 Protein families: genetic information processing
03110 Chaperones and folding catalysts [BR:hsa03110]
255738 (PCSK9)
Peptidases and inhibitors [BR:hsa01002]
Serine peptidases
Family S8: subtilisin family
255738 (PCSK9)
Chaperones and folding catalysts [BR:hsa03110]
Intramolecular chaperones
Subtilisin family
255738 (PCSK9)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
1:55039548..55064852
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| AA seq |
692 aa
MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGT
TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLP
GFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLV
EVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAG
VAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAA
CQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVD
LFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSA
KDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAVARCAPD
EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAP
PAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASC
CHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRD
VSTTGSTSEGAVTAVAICCRSRHLAQASQELQ |
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| NT seq |
2079 nt +upstreamnt +downstreamnt
atgggcaccgtcagctccaggcggtcctggtggccgctgccactgctgctgctgctgctg
ctgctcctgggtcccgcgggcgcccgtgcgcaggaggacgaggacggcgactacgaggag
ctggtgctagccttgcgttccgaggaggacggcctggccgaagcacccgagcacggaacc
acagccaccttccaccgctgcgccaaggatccgtggaggttgcctggcacctacgtggtg
gtgctgaaggaggagacccacctctcgcagtcagagcgcactgcccgccgcctgcaggcc
caggctgcccgccggggatacctcaccaagatcctgcatgtcttccatggccttcttcct
ggcttcctggtgaagatgagtggcgacctgctggagctggccttgaagttgccccatgtc
gactacatcgaggaggactcctctgtctttgcccagagcatcccgtggaacctggagcgg
attacccctccacggtaccgggcggatgaataccagccccccgacggaggcagcctggtg
gaggtgtatctcctagacaccagcatacagagtgaccaccgggaaatcgagggcagggtc
atggtcaccgacttcgagaatgtgcccgaggaggacgggacccgcttccacagacaggcc
agcaagtgtgacagtcatggcacccacctggcaggggtggtcagcggccgggatgccggc
gtggccaagggtgccagcatgcgcagcctgcgcgtgctcaactgccaagggaagggcacg
gttagcggcaccctcataggcctggagtttattcggaaaagccagctggtccagcctgtg
gggccactggtggtgctgctgcccctggcgggtgggtacagccgcgtcctcaacgccgcc
tgccagcgcctggcgagggctggggtcgtgctggtcaccgctgccggcaacttccgggac
gatgcctgcctctactccccagcctcagctcccgaggtcatcacagttggggccaccaat
gcccaagaccagccggtgaccctggggactttggggaccaactttggccgctgtgtggac
ctctttgccccaggggaggacatcattggtgcctccagcgactgcagcacctgctttgtg
tcacagagtgggacatcacaggctgctgcccacgtggctggcattgcagccatgatgctg
tctgccgagccggagctcaccctggccgagttgaggcagagactgatccacttctctgcc
aaagatgtcatcaatgaggcctggttccctgaggaccagcgggtactgacccccaacctg
gtggccgccctgccccccagcacccatggggcaggttggcagctgttttgcaggactgta
tggtcagcacactcggggcctacacggatggccacagccgtcgcccgctgcgccccagat
gaggagctgctgagctgctccagtttctccaggagtgggaagcggcggggcgagcgcatg
gaggcccaagggggcaagctggtctgccgggcccacaacgcttttgggggtgagggtgtc
tacgccattgccaggtgctgcctgctaccccaggccaactgcagcgtccacacagctcca
ccagctgaggccagcatggggacccgtgtccactgccaccaacagggccacgtcctcaca
ggctgcagctcccactgggaggtggaggaccttggcacccacaagccgcctgtgctgagg
ccacgaggtcagcccaaccagtgcgtgggccacagggaggccagcatccacgcttcctgc
tgccatgccccaggtctggaatgcaaagtcaaggagcatggaatcccggcccctcaggag
caggtgaccgtggcctgcgaggagggctggaccctgactggctgcagtgccctccctggg
acctcccacgtcctgggggcctacgccgtagacaacacgtgtgtagtcaggagccgggac
gtcagcactacaggcagcaccagcgaaggggccgtgacagccgttgccatctgctgccgg
agccggcacctggcgcaggcctcccaggagctccagtga |
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