KEGG   DRUG: Acoltremon
Entry
D13125                      Drug                                   
Name
Acoltremon (USAN/INN);
Tryptyr (TN)
Product
TRYPTYR (Alcon Laboratories)
Formula
C18H27NO2
Exact mass
289.2042
Mol weight
289.41
Structure
Remark
Product: D13125<US>
Efficacy
TRP channel agonist
  Disease
Dry eye disease [DS:H01641]
Target
TRPM8 [HSA:79054] [KO:K04983]
  Pathway
hsa04750  Inflammatory mediator regulation of TRP channels
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Transient receptor potential channels
    TRPM8
     D13125  Acoltremon (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D13125
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D13125
Other DBs
CAS: 68489-09-8
PubChem: 513757662
LinkDB
KCF data

ATOM        21
            1   C8y C    23.2400  -14.9100
            2   C8x C    23.2400  -16.3100
            3   C8x C    24.4524  -17.0100
            4   C8y C    25.6649  -16.3100
            5   C8x C    25.6649  -14.9100
            6   C8x C    24.4524  -14.2100
            7   N1b N    22.0276  -14.2100
            8   C5a C    20.8321  -14.9004
            9   C1y C    19.6447  -14.2149
            10  O5a O    20.8320  -16.3097
            11  C1x C    19.6446  -12.8102
            12  C1y C    18.4321  -12.1103
            13  C1x C    17.2197  -12.8104
            14  C1x C    17.2199  -14.2151
            15  C1y C    18.4324  -14.9150
            16  C1a C    18.4320  -10.7102
            17  C1c C    18.4324  -16.3098
            18  C1a C    19.6280  -17.0002
            19  C1a C    17.2032  -17.0196
            20  O2a O    26.8960  -17.0210
            21  C1a C    28.1012  -16.3253
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     9   8 1 #Up
            10    8  10 2
            11    9  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16    9  15 1
            17   12  16 1 #Up
            18   15  17 1 #Down
            19   17  18 1
            20   17  19 1
            21    4  20 1
            22   20  21 1

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