KEGG   DRUG: Spevatamig
Entry
D13158                      Drug                                   
Name
Spevatamig (USAN/INN)
Formula
C6450H9972N1714O2013S44
Exact mass
145055.8343
Mol weight
145145.41
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFIFS SFGMHWVRKA PGKGLEWVAY ISSGRSTMYY
ADSVKGRFTI SRDNSKNTLY LQMNSLTAED TAVYYCARGG FYGNSLDYWG QGTLVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSKVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV CTLPPSRDEL
TKNQVSLSCA VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLVS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT SYWMHWVREA PGQGLEWIGN IDPSDSETHY
AQKFQGRVTL TVDKSTSTVY MELSSLRSED TAVYYCAGTD LAYWGQGTLV TVSSASTKGP
SVFPLAPSSC STSGGTAALG CLVKDYFPEP VTVSWNSGAL TSEVHTFPAV LQSSGLYSLS
SVVTVPSSSL GTQTYICNVN HKPSNTKVDK KVEPKSSDKT HTCPPCPAPE LLGGPSVFLF
PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV
SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP CRDELTKNQV
SLWCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF
SCSVMHEALH NHYTQKSLSL SPGK
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCKSSLSLL NSGNQKNYLT WYQEKPGKAP KLLIYWASTR
ESGVPSRFSG SGSGTDFTLT ISSLQPEDFA TYSCQNAYSY PLTFGQGTKV EIKRTVAAPE
VFIFPPSDEQ LKSGTASVVC LLNNFYPREA KVQWKVDNAL QSGNSQESVT EQDSKDSTYS
LSSTLTLSKA DYEKHKVYAC EVTHQGLSSP VTKSFNRGEC
(light chain)
EIVLTQSPGT LSLSPGERAT LSCHASQNIN VWLSWYQKKP GQAPRLLIYK ASNLHTGIPD
RFSGSGSGTD FTLTISRLEP EDFAVYYCQQ GQSYPFTFGQ GTKVEIKRTV AAPKVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSCN RGES
(Disulfide bridge: H22-H96, H146-H202, H222-L220, H228-l223, H231-h226, H351-h351, H263-H323, H369-H427, h22-h96, h130-l209, h141-h197, h258-h318, h364-h422, L23-L94, L140-L200, l23-l88, l134-l194)
  Type
Peptide
Efficacy
Antineoplastic
  Type
Bispecific antibody
Target
CLDN18 [HSA:51208] [KO:K06087]
CD47 [HSA:961] [KO:K06266]
  Pathway
hsa04514  Cell adhesion molecule (CAM) interaction
hsa04530  Tight junction
hsa04670  Leukocyte transendothelial migration
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    CD47
     D13158  Spevatamig (USAN/INN)
   Other
    CLDN18
     D13158  Spevatamig (USAN/INN)
Other DBs
CAS: 2928515-36-8
PubChem: 518520878
LinkDB

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