KEGG   Homo sapiens (human): 51208
Entry
51208             CDS       T01001                                 
Symbol
CLDN18, SFTA5, SFTPJ
Name
(RefSeq) claudin-18 isoform 1
  KO
K06087  claudin
Organism
hsa  Homo sapiens (human)
Pathway
hsa03272  Virion - Hepatitis viruses
hsa04382  Cornified envelope formation
hsa04514  Cell adhesion molecule (CAM) interaction
hsa04530  Tight junction
hsa04670  Leukocyte transendothelial migration
hsa05130  Pathogenic Escherichia coli infection
hsa05160  Hepatitis C
Network
nt06180  Pathogenic Escherichia coli
  Element
N01287  Tight junction-Actin signaling pathway
Drug target
Osemitamab: D12781
Sonesitatug: D13163
Sonesitatug vedotin: D13164
Spevatamig: D13158
Zolbetuximab: D11527<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03272 Virion - Hepatitis viruses
    51208 (CLDN18)
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecule (CAM) interaction
    51208 (CLDN18)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    51208 (CLDN18)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    51208 (CLDN18)
  09158 Development and regeneration
   04382 Cornified envelope formation
    51208 (CLDN18)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    51208 (CLDN18)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    51208 (CLDN18)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins [BR:hsa03037]
    51208 (CLDN18)
   04147 Exosome [BR:hsa04147]
    51208 (CLDN18)
Cilium and associated proteins [BR:hsa03037]
 Other cilia and associated proteins
  Stereociliary proteins
   51208 (CLDN18)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of ovarian cancer cells
   51208 (CLDN18)
  Exosomal proteins of colorectal cancer cells
   51208 (CLDN18)
SSDB
Motif
Pfam: PMP22_Claudin Claudin_2 TAXIMIN
Other DBs
NCBI-GeneID: 51208
NCBI-ProteinID: NP_057453
OMIM: 609210
HGNC: 2039
Ensembl: ENSP00000183605.5
UniProt: P56856
LinkDB
Position
3:137998816..138033649
AA seq 261 aa
MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGF
TECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLT
SGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWV
AGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKI
YDGGARTEDEVQSYPSKHDYV
NT seq 786 nt   +upstreamnt  +downstreamnt
atgtccaccaccacatgccaagtggtggcgttcctcctgtccatcctggggctggccggc
tgcatcgcggccaccgggatggacatgtggagcacccaggacctgtacgacaaccccgtc
acctccgtgttccagtacgaagggctctggaggagctgcgtgaggcagagttcaggcttc
accgaatgcaggccctatttcaccatcctgggacttccagccatgctgcaggcagtgcga
gccctgatgatcgtaggcatcgtcctgggtgccattggcctcctggtatccatctttgcc
ctgaaatgcatccgcattggcagcatggaggactctgccaaagccaacatgacactgacc
tccgggatcatgttcattgtctcaggtctttgtgcaattgctggagtgtctgtgtttgcc
aacatgctggtgactaacttctggatgtccacagctaacatgtacaccggcatgggtggg
atggtgcagactgttcagaccaggtacacatttggtgcggctctgttcgtgggctgggtc
gctggaggcctcacactaattgggggtgtgatgatgtgcatcgcctgccggggcctggca
ccagaagaaaccaactacaaagccgtttcttatcatgcctcaggccacagtgttgcctac
aagcctggaggcttcaaggccagcactggctttgggtccaacaccaaaaacaagaagata
tacgatggaggtgcccgcacagaggacgaggtacaatcttatccttccaagcacgactat
gtgtaa

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