KEGG   DRUG: Surlorian
Entry
D13172                      Drug                                   
Name
Surlorian (USAN/INN)
Formula
C18H19NO3S
Exact mass
329.1086
Mol weight
329.41
Structure
Remark
Chemical structure group: DG03360
Efficacy
Ryanodine receptor stabilizer
Comment
Treatment of cardiac and skeletal muscle genetic disorders such as Catecholaminergic Polymorphic Ventricular Tachycardia and RYR1-related myopathies. Treatment of heart failure.
Target
RYR [HSA:6261 6262 6263] [KO:K04961 K04962 K04963]
  Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04371  Apelin signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Ryanodine receptors (RYR)
    RYR
     D13172  Surlorian (USAN/INN)
Other DBs
CAS: 1467605-57-7
PubChem: 519518022
LinkDB
KCF data

ATOM        23
            1   C8x C     5.3200  -14.9100
            2   C8y C     5.3200  -16.3100
            3   C8x C     6.5100  -17.0100
            4   C8y C     7.7700  -16.3100
            5   C8y C     7.7700  -14.9100
            6   C8x C     6.5100  -14.2100
            7   S2x S     8.8900  -14.0000
            8   C1x C    10.2200  -14.3500
            9   C1x C    10.8500  -15.6100
            10  N1y N    10.2200  -16.8700
            11  C1x C     8.8900  -17.1500
            12  O2a O     4.1047  -17.0051
            13  C1a C     2.9163  -16.3123
            14  C1b C    11.0754  -17.9783
            15  C8y C    12.4598  -17.9680
            16  C8x C    13.1785  -19.1916
            17  C8x C    14.5785  -19.1810
            18  C8y C    15.2694  -17.9634
            19  C8x C    14.5507  -16.7399
            20  C8x C    13.1507  -16.7504
            21  C6a C    16.6694  -17.9634
            22  O6a O    17.3787  -19.1914
            23  O6a O    17.3555  -16.7750
BOND        25
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     8   9 1
            8     9  10 1
            9     7   8 1
            10    4  11 1
            11    5   7 1
            12   10  11 1
            13    2  12 1
            14   12  13 1
            15   10  14 1
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23   18  21 1
            24   21  22 1
            25   21  23 2

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