KEGG ORTHOLOGY: K04961

ORTHOLOGY: K04961

Entry

K04961                      KO

Symbol

RYR1

Name

ryanodine receptor 1

Pathway

map04020

Calcium signaling pathway

map04371

Apelin signaling pathway

map04713

Circadian entrainment

map04730

Long-term depression

map04921

Oxytocin signaling pathway

map05017

Spinocerebellar ataxia

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00699

Central core disease

H01310

Multi-minicore disease

H01810

Congenital myopathy

H02646

Malignant hyperthermia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K04961  RYR1; ryanodine receptor 1
   04020 Calcium signaling pathway
    K04961  RYR1; ryanodine receptor 1
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04961  RYR1; ryanodine receptor 1
  09156 Nervous system
   04730 Long-term depression
    K04961  RYR1; ryanodine receptor 1
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04961  RYR1; ryanodine receptor 1
09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    K04961  RYR1; ryanodine receptor 1
   05020 Prion disease
    K04961  RYR1; ryanodine receptor 1
   05022 Pathways of neurodegeneration - multiple diseases
    K04961  RYR1; ryanodine receptor 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K04961  RYR1; ryanodine receptor 1
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04961  RYR1; ryanodine receptor 1
   04040 Ion channels
    K04961  RYR1; ryanodine receptor 1
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04961  RYR1; ryanodine receptor 1
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04961  RYR1; ryanodine receptor 1
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Ryanodine receptor
   K04961  RYR1; ryanodine receptor 1

Other DBs

GO:

0005219

TC:

1.A.3.1.2

Genes

HSA:	6261(RYR1)

PTR:	100612063(RYR1)

PPS:	100992272(RYR1)

GGO:	101143735(RYR1)

PON:	100447042(RYR1)

PPYG:

129019620(RYR1)

NLE:

100592793

HMH:	116480045(RYR1)

SSYN:

129466689(RYR1)

MCC:	693612(RYR1)

MCF:	102129553(RYR1)

MTHB:

126941959

MNI:	105495636(RYR1)

CSAB:

103234633(RYR1)

CATY:

105594519(RYR1)

PANU:

101026547

TGE:	112613556(RYR1)

MLEU:

105534627(RYR1)

RRO:	104679962(RYR1)

RBB:	108538989(RYR1)

TFN:	117092481(RYR1)

PTEH:

111554005(RYR1)

CANG:

105519213(RYR1)

CJC:	100405957(RYR1)

SBQ:	101040405(RYR1)

CIMI:

108287888(RYR1)

ANAN:

105707652(RYR1)

MMUR:

105877018(RYR1)

LCAT:

123624371(RYR1)

PCOQ:

105820495(RYR1)

OGA:	100962804(RYR1)

MMU:	20190(Ryr1)

MCAL:

110299024(Ryr1)

MPAH:

110330776(Ryr1)

RNO:	114207(Ryr1)

MCOC:

116101936(Ryr1)

ANU:	117705787(Ryr1)

ASYL:

127672131(Ryr1)

MUN:	110552535(Ryr1)

CGE:	100766013(Ryr1)

MAUA:

101840708(Ryr1)

PROB:

127238770(Ryr1)

PLEU:

114684981(Ryr1)

PMAV:

102910147(Ryr1)

MORG:

121449089(Ryr1)

MFOT:

126486804

AAMP:

119820756(Ryr1)

NGI:	103750787(Ryr1)

HGL:	101708954(Ryr1)

CPOC:

100727848(Ryr1)

CCAN:

109695821(Ryr1)

DORD:

105993062(Ryr1)

DSP:	122097395(Ryr1)

DMER:

138811146 138812390

PLOP:

125367916(Ryr1)

NCAR:

124966810

MMMA:

107151657(Ryr1)

ITI:	101961602(Ryr1)

OCU:	100009540(RYR1)

OPI:	101521583(RYR1)

OCZ:	121153676(RYR1) 121166876

TUP:	102475336(RYR1)

GVR:	103591479(RYR1)

CFA:	606491(RYR1)

CLUD:

112645518(RYR1)

VVP:	112928307(RYR1)

VLG:	121483797(RYR1)

NPO:	129499919(RYR1)

AML:	100471044(RYR1)

UMR:	103661069(RYR1)

UAH:	113243259(RYR1)

UAR:	123784559(RYR1)

ELK:

111161376

LLV:

125089926

MPUF:

101672983(RYR1)

MNP:	132005592(RYR1)

MLK:	131818258(RYR1)

NVS:	122911638(RYR1)

ORO:	101364655(RYR1)

EJU:	114198938(RYR1)

ZCA:	113935520(RYR1)

MLX:	118022771(RYR1)

NSU:	110590208(RYR1)

LWW:	102738593(RYR1)

FCA:	101094224(RYR1)

PYU:	121011339(RYR1)

PCOO:

112851287(RYR1)

PBG:	122494096(RYR1)

PVIV:

125153088(RYR1)

LRUF:

124511751

LGF:	123578999(RYR1)

AJU:

106980247

PTG:	102971670(RYR1)

PPAD:

109256597(RYR1)

PUC:

125916168

PLEZ:

122208926(RYR1)

HHV:	120220611(RYR1)

BTA:	100139857(RYR1)

BOM:	102275567(RYR1)

BBUB:

102398635(RYR1)

BBIS:

104995440(RYR1)

CHX:	102179229(RYR1)

OAS:	101112591(RYR1)

BTAX:

128063697(RYR1)

CSUM:

138097089(RYR1)

ODA:	120873294(RYR1)

CCAD:

122420334(RYR1)

MREE:

136161303(RYR1)

OVR:	110129955(RYR1)

MBEZ:

129546860(RYR1)

SSC:	396718(RYR1)

CFR:	102516436(RYR1)

CDK:	105096948(RYR1)

VPC:	102525492(RYR1)

BACU:

103007765(RYR1)

BMUS:

118884703(RYR1)

LVE:	103069357(RYR1)

OOR:	101283632(RYR1)

LALB:

132510054(RYR1)

GMF:	115862477(RYR1)

DDP:	132416022(RYR1)

DLE:	111180892(RYR1)

PCAD:

102976725

PSIU:

116743441(RYR1)

PPHC:

136141147(RYR1)

NASI:

112392404(RYR1)

ECB:	100034090(RYR1)

EPZ:	103541052(RYR1)

EAI:	106836101(RYR1)

MYB:	102253755(RYR1)

MYD:	102763591(RYR1)

MMYO:

118674213(RYR1)

MLF:	102437305(RYR1)

MDT:	132216944(RYR1)

MYUM:

138996884(RYR1)

PKL:	118702392(RYR1)

EFUS:

103284712(RYR1)

MNA:	107532181(RYR1)

DRO:	112319987(RYR1)

SHON:

118976360(RYR1)

AJM:	119046710(RYR1)

PDIC:

114510907(RYR1)

PHAS:

123823738(RYR1)

MMF:	118639622(RYR1)

PPAM:

129083234(RYR1)

HAI:

109395341

RFQ:	117034373(RYR1)

PALE:

102891286(RYR1)

PGIG:

120596309(RYR1)

PVP:	105300232(RYR1) 105304450

RAY:	107520956(RYR1)

MJV:	108399498(RYR1)

TOD:	119250147(RYR1)

SARA:

101550906(RYR1)

SFUM:

130044494(RYR1)

SETR:

126028507(RYR1)

LAV:	100655020(RYR1)

TMU:

101351543

ETF:	101646433(RYR1)

DNM:

101431584

MDO:	100013232(RYR1)

GAS:	123240034(RYR1)

SHR:	100916717(RYR1)

AFZ:

127556159

PCW:	110202421(RYR1)

TVP:	118835874(RYR1)

PBRV:

138154063(RYR1)

MLAO:

141509453(RYR1)

OAA:	100681936(RYR1)

TACU:

119946168(RYR1)

GGA:	101748756(RYR1L1)

MGP:	100008574(RYR1)

ACYG:

125181746(RYR1)

CATA:

LSR:

PMOA:

ATRC:

OMA:

PHI:	102114265(RYR1)

ACOE:

138100457(RYR1)

ZLE:	135460641(RYR1)

HRT:

120747926

CCIC:

134055980(RYR1)

AGEN:

126035734

HHAR:

128138077 128138179

CBOR:

142073996(RYR1)

CBOY:

140645390(RYR1)

CLV:

102094459

CNIC:

136002792(RYR1)

CUCA:

104068700(RYR1)

AROW:

112961560

ASN:	102379620(RYR1)

AMJ:	102563585(RYR1)

CIZ:	142024205(RYR1)

CMY:	102946217(RYR1)

CCAY:

125628477(RYR1)

DCC:	119847088(RYR1)

CPIC:

101952293(RYR1)

TST:	117888922(RYR1)

MRV:	120388242(RYR1)

ACS:	100558429(ryr1)

ASAO:

132780560(RYR1)

PVT:	110075640(RYR1)

SUND:

121915128(RYR1)

PBI:	103063254(RYR1)

PMUR:

107293912(RYR1)

CTIG:

120319895(RYR1)

PCAE:

139320873(RYR1)

APRI:

131204715(RYR1)

PTEX:

113445907(RYR1)

VKO:	123025844(RYR1)

PMUA:

114603221(RYR1)

PRAF:

128420242(RYR1)

ZVI:	118086895(RYR1)

HCG:	128332667(RYR1)

GJA:

107117768

EMC:	129343056(RYR1)

XLA:	108698642(ryr1.L) 108700581

XTR:	100495378(ryr1)

NPR:	108786654(RYR1)

RTEM:

120913406(RYR1)

ACAT:

141107769(RYR1)

PADS:

140342948(RYR1)

BBUF:

121009321(RYR1)

BGAR:

122946356(RYR1)

DTC:	141051948(RYR1)

PWL:	138259340(RYR1)

MUO:	115480002(RYR1)

GSH:	117364638(RYR1)

DRE:	570245(ryr1b) 798565(ryr1a)

SRX:	107728853 107734428 107758351

SANH:

107676751 107686144 107691669

SGH:	107549251 107577624 107589453 107596888

CCAR:

109055440 109088186 109108995

CAUA:

113054428 113061686 113109947 113118448

CGIB:

127934027 127966454 127977884 128021066

PTET:

122352824(ryr1a) 122363087(ryr1b)

LROH:

127172525(ryr1a) 127181099(ryr1b)

GRF:	141299183(ryr1a) 141345284(ryr1b)

OMC:	131523905(ryr1b) 131548534(ryr1a)

PPRM:

120482698(ryr1a) 120487887(ryr1b)

RKG:	130103866(ryr1b) 130105482(ryr1a)

MAMB:

125254212(ryr1b) 125262225(ryr1a)

CIDE:

127499307 127520023

CERY:

137023454(ryr1b) 137028681(ryr1a)

MASI:

127417004 127433765 127456501

TROS:

130545693(ryr1a) 130562907(ryr1b)

TDW:	130412251(ryr1a) 130435579(ryr1b)

MANU:

129419546(ryr1b) 129446801(ryr1a)

PDAB:

135741325(ryr1a) 135773440(ryr1b)

IPU:	108264731 108276801(ryr1a)

IFU:	128606446 128620136(ryr1a)

PHYP:

113523728 113526686

SMEO:

124393574(ryr1a) 124395450

TFD:	113650233(ryr1a) 113650773

TVC:	132851833 132862931(ryr1a)

CGAR:

128505509(ryr1a) 128527421

NGRA:

132873839(ryr1a) 132887638

TRN:	134323614 134332249(ryr1a)

AMEX:

103022324 103047751(ryr1a)

CMAO:

118817771 118824380(ryr1a)

EEE:	113575434 113576609

CHAR:

105890469 105897176(ryr1b)

SPIL:

134080645 134099020(ryr1b)

ASAD:

121683981(ryr1b) 121709223(ryr1a)

TRU:	101072939 101073831

TFS:	130534577(ryr1b) 130538094

TNG:	GSTEN00019016G001

LCO:	104924595 104934276

NCC:	104963769 104967745(ryr1)

TBEN:

117471064(ryr1b) 117490221

CGOB:

115017837 115019446

PGEO:

117457471(ryr1b) 117458215

GACU:

117535418 117555619(ryr1b)

EMAC:

134871768 134880514(ryr1b)

ELY:	117259471(ryr1b) 117267084

EFO:	125888916(ryr1b) 125898947

PLEP:

121943032(ryr1b) 121952273

SLUC:

116040031(ryr1b) 116064741(ryr1a)

ECRA:

117938068(ryr1b) 117955843

ESP:	116672230 116700122

PFLV:

114551697 114566648

GAT:	120817717(ryr1b) 120822199

PPUG:

119215626 119216058(ryr1b)

AFB:	129097610(ryr1b) 129113876

CLUM:

117741370(ryr1b) 117742824(ryr1a)

PSWI:

130210294(ryr1b) 130210325

CANA:

137790758(ryr1b) 137802210

CVE:	137874656(ryr1b) 137876338

MSAM:

119883493(ryr1b) 119895837

SCHU:

122879072(ryr1b) 122888781

CUD:	121518712 121524386(ryr1b)

SPUL:

138596788(ryr1b) 138597199

LMIX:

132980787(ryr1b) 132988730

HTC:	141791277 141797551(ryr1b)

ALAT:

119030801 119034262(ryr1b)

ASTR:

137597234(ryr1b) 137605748

MZE:	101476569 101487104

ONL:	100708262 100709030

OAU:	116336197 116336492(ryr1b)

OLA:	101160087(ryr1) 101167142

OML:	112141892 112149715(ryr1b)

CSAI:

133442018(ryr1b) 133459660

XMA:	102218820 102219066

XCO:	114153062 114161320

XHE:	116716537 116728512

PRET:

103475196(ryr1) 103475680

PFOR:

103138257 103141398

PLAI:

106947412 106952220

PMEI:

106918686 106921753

GAF:	122833037(ryr1b) 122844448

PPRL:

129359247(ryr1b) 129368545

CVG:	107089817 107091628

CTUL:

119778063 119785721(ryr1b)

GMU:	124876344 124883896(ryr1b)

NFU:	107379827 107386401

KMR:	108236972 108244668(ryr1b)

ALIM:

106514048 106529663

NWH:	119420597(ryr1a)

AOCE:

111567121 111579598(ryr1b)

EJA:	138196436 138205265(ryr1b)

BFRE:

138629565 138634217(ryr1b)

MCEP:

125013104(ryr1b) 125021093

CSEM:

103377851 103395719

POV:	109628722 109630037

SSEN:

122773170(ryr1b) 122779385(ryr1a)

SSOE:

131458276(ryr1a) 131462687(ryr1b)

HHIP:

117772371(ryr1b) 117774331(ryr1a)

HSP:	118106529(ryr1b) 118122262(ryr1a)

PPLT:

128440405(ryr1b) 128457533

SMAU:

118299403(ryr1b) 118299993(ryr1a)

LCF:	108876138 108893541

SDU:	111216778 111234542

SLAL:

111662206 111666180

XGL:	120791720(ryr1b) 120802314

HCQ:	109510827 109517964

SSCV:

125972852(ryr1b) 125981806

SBIA:

133491703 133504515

PEE:	133405560(ryr1b) 133415578

PTAO:

133467090 133481858(ryr1b)

BPEC:

110158641 110163772

ENY:	140360805 140366170(ryr1b)

MALB:

109959404 109963283

BSPL:

114868419(ryr1b) 114869714

SJO:	128360106(ryr1b) 128371656

SSCO:

133981012(ryr1b) 133994415

TTY:	137186418(ryr1b) 137195557

GMH:	115546754 115561656

SASA:

106603084(ryr1)

STRU:

115154755 115204363 115206697

OTW:	112218996 112228881 112230654

OMY:	110503433(ryr1b) 110509422 110533121

OGO:	124006510(ryr1b) 124006950 124006954

ONE:	115101391 115135571

OKI:	109872649 109873878 109882600

OKE:	118384831 118390425 118399867(ryr1b)

OMM:	135544223 135546739 135550359

OCLA:

139382922 139388770 139418579

SALP:

111950321 111964257

SNH:	120021085 120028542(ryr1b) 120057569

SFON:

129831758(ryr1b) 129863154 129868982

CCLU:

121541906 121567835(ryr1b) 121579541

ELS:	105010866 105027040

OEP:	134029454(ryr1b) 134040075

SFM:	108924840 108941608

PKI:	111838045 111841417(ryr1)

AANG:

118209433(ryr1b) 118236393

AROT:

135235554(ryr1b) 135263955

CCOG:

133107661(ryr1b) 133133347

LOC:	102685847(ryr1)

PSPA:

121303771 121304837

ARUT:

117394205 117415496

PSEX:

120538749

LCM:	102356360(RYR1)

CMK:

RTP:

CPLA:

CPUN:

HOC:

SCAU:

STOZ:

LERI:

HAKA:

PMRN:

LRJ:

Reference

PMID:2298749

Authors

Zorzato F, Fujii J, Otsu K, Phillips M, Green NM, Lai FA, Meissner G, MacLennan DH

Title

Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.

Journal

J Biol Chem 265:2244-56 (1990)

Sequence

[hsa:6261]

LinkDB

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