KEGG   DISEASE: Pertussis
Entry
H00319                      Disease                                

Name
Pertussis;
Whooping cough
Description
Pertussis, or whooping cough, caused by the gram-negative bacillus Bordetella pertussis, is a highly contagious, acute respiratory disease of humans. Despite high vaccination rates, this illness has re-emerged worldwide, causing approximately 300 000 deaths each year. Waning immunity after childhood immunization has resulted in a growing pool of susceptible adolescents and adults who are capable of transmitting pertussis to vulnerable unvaccinated or incompletely vaccinated infants. The hallmark symptoms of pertussis are paroxysmal coughing with whooping and post-tussive vomiting. Persistent coughing may last for weeks to months with a gradual decrease in frequency and severity. However, it should be noted that B. pertussis infections, particularly in hosts with partial immunity to the bacterium, may also follow a much milder or subclinical course. Complications that are frequently associated with classical pertussis include pneumonia, otitis media, seizures, encephalopathy, and (brain) hemorrhages.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by beta proteobacteria
   H00319  Pertussis
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Other bacterial diseases
   1C12  Whooping cough
    H00319  Pertussis
Pathway
hsa05133  Pertussis
Pathogen
Bordetella pertussis [GN:bpe bpc bpet]
Bordetella parapertussis [GN:bpa]
  Module
M00574  Pertussis pathogenicity signature, pertussis toxin
M00575  Pertussis pathogenicity signature, T1SS
Drug
Erythromycin [DR:D00140]
Erythromycin ethylsuccinate [DR:D01361]
Erythromycin stearate [DR:D02184]
Other DBs
ICD-11: 1C12
ICD-10: A37
MeSH: D014917
MedlinePlus: 001561
Reference
  Authors
de Gouw D, Diavatopoulos DA, Bootsma HJ, Hermans PW, Mooi FR
  Title
Pertussis: a matter of immune modulation.
  Journal
FEMS Microbiol Rev 35:441-74 (2011)
DOI:10.1111/j.1574-6976.2010.00257.x
Reference
  Authors
Mooi FR
  Title
Bordetella pertussis and vaccination: the persistence of a genetically monomorphic pathogen.
  Journal
Infect Genet Evol 10:36-49 (2010)
DOI:10.1016/j.meegid.2009.10.007
Reference
  Authors
Locht C
  Title
Molecular aspects of Bordetella pertussis pathogenesis.
  Journal
Int Microbiol 2:137-44 (1999)
Reference
  Authors
Heininger U
  Title
Update on pertussis in children.
  Journal
Expert Rev Anti Infect Ther 8:163-73 (2010)
DOI:10.1586/eri.09.124
Reference
  Authors
Munoz FM
  Title
Pertussis in infants, children, and adolescents: diagnosis, treatment, and prevention.
  Journal
Semin Pediatr Infect Dis 17:14-9 (2006)
DOI:10.1053/j.spid.2005.11.005
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