| Entry |
|
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| Name |
Erythromycin (JP18/USP/INN);
Akne-mycin (TN);
Eryc (TN);
Erygel (TN);
Pce (TN);
Staticin (TN);
T-stat (TN) |
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| Product |
|
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| Generic |
ERY (Bryant Ranch Prepack), ERY (Padagis Israel Pharmaceuticals), ERY-TAB (Arbor Pharmaceuticals), ERY-TAB (PD-Rx Pharmaceuticals), ERY-TAB (PD-Rx Pharmaceuticals), ERY-TAB (PD-Rx Pharmaceuticals), ERYTHROMYCIN (A-S Medication Solutions), ERYTHROMYCIN (A-S Medication Solutions), ERYTHROMYCIN (A-S Medication Solutions), ERYTHROMYCIN (ARMAS PHARMACEUTICALS), ERYTHROMYCIN (Alembic Pharmaceuticals Limited), ERYTHROMYCIN (Alembic Pharmaceuticals), ERYTHROMYCIN (Amneal Pharmaceuticals NY LLC), ERYTHROMYCIN (Amneal Pharmaceuticals NY LLC), ERYTHROMYCIN (Arbor Pharmaceuticals), ERYTHROMYCIN (Arbor Pharmaceuticals), ERYTHROMYCIN (Ascend Laboratories), ERYTHROMYCIN (Asclemed USA), ERYTHROMYCIN (Asclemed USA), ERYTHROMYCIN (Asclemed USA), ERYTHROMYCIN (Bausch & Lomb Incorporated), ERYTHROMYCIN (Bryant Ranch Prepack), ERYTHROMYCIN (Bryant Ranch Prepack), ERYTHROMYCIN (Bryant Ranch Prepack), ERYTHROMYCIN (Bryant Ranch Prepack), ERYTHROMYCIN (Cadila Pharmaceuticals Limited), ERYTHROMYCIN (Cardinal Health 107), ERYTHROMYCIN (Golden State Medical Supply), ERYTHROMYCIN (Golden State Medical Supply), ERYTHROMYCIN (MICRO LABS LIMITED), ERYTHROMYCIN (Mayne Pharma), ERYTHROMYCIN (Modavar Pharmaceuticals LLC), ERYTHROMYCIN (Mylan Pharmaceuticals), ERYTHROMYCIN (Nivagen Pharmaceuticals), ERYTHROMYCIN (NuCare Pharmaceuticals), ERYTHROMYCIN (NuCare Pharmaceuticals), ERYTHROMYCIN (NuCare Pharmaceuticals), ERYTHROMYCIN (NuCare Pharmaceuticals), ERYTHROMYCIN (NuCare Pharmaceuticals), ERYTHROMYCIN (NuCare Pharmaceuticals), ERYTHROMYCIN (Orange Pharmaceuticals USA LLC), ERYTHROMYCIN (PD-Rx Pharmaceuticals), ERYTHROMYCIN (PD-Rx Pharmaceuticals), ERYTHROMYCIN (Padagis Israel Pharmaceuticals), ERYTHROMYCIN (Padagis Israel Pharmaceuticals), ERYTHROMYCIN (Padagis US LLC), ERYTHROMYCIN (Preferred Pharmaceuticals), ERYTHROMYCIN (Preferred Pharmaceuticals), ERYTHROMYCIN (Proficient Rx LP), ERYTHROMYCIN (Proficient Rx LP), ERYTHROMYCIN (Proficient Rx LP), ERYTHROMYCIN (REMEDYREPACK), ERYTHROMYCIN (REMEDYREPACK), ERYTHROMYCIN (RPK Pharmaceuticals), ERYTHROMYCIN (RedPharm Drug), ERYTHROMYCIN (RedPharm Drug), ERYTHROMYCIN (Teva Pharmaceuticals USA), ERYTHROMYCIN (Torrent Pharmaceuticals Limited), ERYTHROMYCIN (Torrent Pharmaceuticals Limited), ERYTHROMYCIN (Wilshire Pharmaceuticals), ERYTHROMYCIN (Wilshire Pharmaceuticals), ERYTHROMYCIN (Zydus Lifesciences Limited), ERYTHROMYCIN (Zydus Lifesciences Limited), ERYTHROMYCIN (Zydus Pharmaceuticals USA), ERYTHROMYCIN (Zydus Pharmaceuticals USA) |
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| Formula |
C37H67NO13
|
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| Exact mass |
733.4612
|
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| Mol weight |
733.93
|
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| Structure |
|
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| Simcomp |
|
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| Sequence |
0 Pyk 1 Mtk 2 Mtn 3 Mte 4 Mtk 5 Mtk 6 Mtn |
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| Type |
PK |
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| Source |
Saccharopolyspora erythraea [TAX: 1836]
|
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| Class |
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
Transporter inhibitor
DG01622 ABCB1 inhibitor
|
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| Remark |
| Therapeutic category: | 6141 |
| Product (DG00436): | D00140<JP/US> D01361<JP/US> D02009<JP/US> D02184<JP> |
| Product (mixture): | D11646<US> |
|
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| Efficacy |
Antibacterial, Protein biosynthesis inhibitor |
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| Disease |
|
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| Target |
50S ribosomal subunit |
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| Pathway |
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| Metabolism |
|
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| Interaction |
CYP inhibition: CYP3A [HSA: 1576 1577 1551]
Transporter inhibition: ABCB1 [HSA: 5243]
|
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| Biosynthesis |
| map00522 | Biosynthesis of 12-, 14- and 16-membered macrolides |
|
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| Structure map |
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| Other map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AF Antiinfectives for treatment of acne
D10AF02 Erythromycin
D00140 Erythromycin (JP18/USP/INN) <JP/US>
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
J01FA Macrolides
J01FA01 Erythromycin
D00140 Erythromycin (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA Antibiotics
S01AA17 Erythromycin
D00140 Erythromycin (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
Macrolides
Erythromycin
D00140 Erythromycin (JP18/USP/INN)
Dermatological Agents
Topical Anti-infectives
Antibacterials, dermatological
Erythromycin
D00140 Erythromycin (JP18/USP/INN)
Ophthalmic Agents
Ophthalmic Anti-Infectives
Antibacterials, Ophthalmic
Erythromycin
D00140 Erythromycin (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
614 Acting mainly on gram-positive bacteria and mycoplasma
6141 Erythromycins
D00140 Erythromycin (JP18/USP/INN)
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
DG00436 Erythromycin
D00140 Erythromycin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00436 Erythromycin
D00140 Erythromycin
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG00436 Erythromycin
D00140 Erythromycin
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00436 Erythromycin
D00140 Erythromycin
Drug classes [BR:br08332]
Antibacterial
DG01551 Macrolide antibiotic
D00140 Erythromycin
Antimicrobials [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
D00140 Erythromycin (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00140 Erythromycin
D00140 Erythromycin enteric-coated tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00140
Drug transporters
D00140
Prodrugs [br08324.html]
D00140
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
DG00436 Erythromycin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00436 Erythromycin
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG00436 Erythromycin
Transporter inhibitor
DG01622 ABCB1 inhibitor
DG00436 Erythromycin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
DG00436 Erythromycin
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 51
1 C1y C 29.5344 -13.7288
2 C1z C 29.5344 -12.3594
3 C1y C 28.3449 -14.4078
4 O2a O 31.5246 -14.4484
5 C1x C 28.3449 -11.6747
6 O1a O 30.5672 -11.3672
7 C1a C 30.8225 -12.7945
8 C1y C 28.3449 -15.7772
9 C1a C 27.3697 -13.3814
10 C1y C 33.1096 -13.7303
11 C1y C 28.3449 -10.2995
12 O2a O 29.0876 -17.1408
13 C1y C 27.1669 -16.4620
14 C1y C 34.2830 -14.4247
15 O2x O 33.1216 -12.3614
16 C5x C 27.1669 -9.6205
17 C1a C 29.5344 -9.6205
18 C1y C 30.6105 -17.5606
19 C7x C 25.9774 -15.7772
20 C1a C 27.1669 -17.8312
21 C1y C 35.4739 -13.7601
22 O1a O 34.2739 -15.7986
23 C1y C 34.3175 -11.6941
24 C1y C 25.9774 -10.2995
25 O5x O 27.1669 -8.2511
26 C1x C 30.6105 -18.9243
27 O2x O 31.8001 -16.8760
28 O7x O 25.9774 -14.4078
29 O6a O 24.9155 -16.7288
30 C1x C 35.4884 -12.3963
31 N1c N 36.6522 -14.4516
32 C1a C 34.3373 -10.3274
33 C1y C 25.9774 -11.6747
34 C1a C 24.7937 -9.6205
35 C1z C 31.8001 -19.6148
36 C1y C 32.9779 -17.5606
37 C1y C 24.7937 -13.7288
38 C1z C 24.7937 -12.3594
39 O1a O 27.1669 -12.3594
40 C1y C 32.9779 -18.9243
41 O2a O 31.8001 -20.9437
42 C1a C 33.2507 -20.6013
43 C1a C 34.1675 -16.8818
44 C1b C 23.6099 -14.4078
45 C1a C 23.5404 -12.9279
46 O1a O 23.5404 -11.6690
47 O1a O 34.1675 -19.6148
48 C1a C 32.9026 -21.9069
49 C1a C 23.5747 -15.5334
50 C1a C 37.9042 -13.7409
51 C1a C 36.7130 -15.8195
BOND 53
1 1 2 1
2 1 3 1
3 1 4 1 #Down
4 2 5 1
5 2 6 1 #Up
6 2 7 1 #Down
7 3 8 1
8 3 9 1 #Down
9 10 4 1 #Down
10 5 11 1
11 8 12 1 #Down
12 8 13 1
13 10 14 1
14 10 15 1
15 11 16 1
16 11 17 1 #Down
17 18 12 1 #Down
18 13 19 1
19 13 20 1 #Up
20 14 21 1
21 14 22 1 #Up
22 15 23 1
23 16 24 1
24 16 25 2
25 18 26 1
26 18 27 1
27 19 28 1
28 19 29 2
29 21 30 1
30 21 31 1 #Down
31 23 32 1 #Down
32 24 33 1
33 24 34 1 #Up
34 26 35 1
35 27 36 1
36 28 37 1
37 33 38 1
38 33 39 1 #Up
39 35 40 1
40 35 41 1 #Down
41 35 42 1
42 36 43 1 #Up
43 37 44 1 #Down
44 38 45 1 #Down
45 38 46 1 #Up
46 40 47 1 #Down
47 41 48 1
48 44 49 1
49 23 30 1
50 36 40 1
51 37 38 1
52 31 50 1
53 31 51 1
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