KEGG   DISEASE: Tropical calcific pancreatitis
Entry
H00932                      Disease                                

Name
Tropical calcific pancreatitis
Description
Tropical calcific pancreatitis (TCP) is a subtype of chronic pancreatitis unique to developing countries in tropical regions. Patients present with recurrent abdominal pain, nutritional deficiencies, and insulin-requiring diabetes resulting from chronic pancreatitis before age 30. Several environmental and genetic factors are implicated in TCP.
Category
Pancreas disease
Brite
Human diseases [BR:br08402]
 Digestive system diseases
  Pancreas diseases
   H00932  Tropical calcific pancreatitis
Human diseases in ICD-11 classification [BR:br08403]
 13 Diseases of the digestive system
  Diseases of pancreas
   DC32  Chronic pancreatitis
    H00932  Tropical calcific pancreatitis
Related
pathway
hsa04142  Lysosome
hsa04612  Antigen processing and presentation
Gene
SPINK1 [HSA:6690] [KO:K23417]
CTRC (non-European population) [HSA:11330] [KO:K01311]
CTSB [HSA:1508] [KO:K01363]
Env factor
Protein malnutrition
Ingestion of cassava roots (cyanogenic glycosides)
Other DBs
ICD-11: DC32.5
MeSH: C564276
OMIM: 608189
Reference
PMID:18604651 (description, gene, env_factor)
  Authors
Witt H, Bhatia E
  Title
Genetic aspects of tropical calcific pancreatitis.
  Journal
Rev Endocr Metab Disord 9:213-26 (2008)
DOI:10.1007/s11154-008-9088-y
Reference
PMID:12360463 (description, gene, env_factor)
  Authors
Bhatia E, Choudhuri G, Sikora SS, Landt O, Kage A, Becker M, Witt H
  Title
Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations.
  Journal
Gastroenterology 123:1020-5 (2002)
DOI:10.1053/gast.2002.36028
Reference
  Authors
Sundaresan S, Chacko A, Dutta AK, Bhatia E, Witt H, Te Morsche RH, Jansen JB, Drenth JP
  Title
Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis.
  Journal
Pancreatology 9:145-9 (2009)
DOI:10.1159/000178885
Reference
  Authors
Reddy DN, Prasad SS
  Title
Genetic basis of chronic pancreatitis in Asia Pacific region.
  Journal
J Gastroenterol Hepatol 26 Suppl 2:2-5 (2011)
DOI:10.1111/j.1440-1746.2010.06598.x
Reference
  Authors
Rosendahl J, Witt H, Szmola R, Bhatia E, Ozsvari B, Landt O, Schulz HU, Gress TM, Pfutzer R, Lohr M, Kovacs P, Bluher M, Stumvoll M, Choudhuri G, Hegyi P, te Morsche RH, Drenth JP, Truninger K, Macek M Jr, Puhl G, Witt U, Schmidt H, Buning C, Ockenga J, Kage A, Groneberg DA, Nickel R, Berg T, Wiedenmann B, Bodeker H, Keim V, Mossner J, Teich N, Sahin-Toth M
  Title
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis.
  Journal
Nat Genet 40:78-82 (2008)
DOI:10.1038/ng.2007.44
Reference
  Authors
Mahurkar S, Idris MM, Reddy DN, Bhaskar S, Rao GV, Thomas V, Singh L, Chandak GR
  Title
Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis.
  Journal
Gut 55:1270-5 (2006)
DOI:10.1136/gut.2005.087403
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