Neorickettsia sennetsu, an obligate intracellular bacteria closely related to Ehrlichia and Anaplasma, causes an infectious mononucleosis-like disease. It is very likely linked to consumption of raw fish in tropical Asia. Patients with sennetsu neorickettsiosis experience acute febrile disease, malaise, myalgias, pharyngitis, anorexia, generalized lymphadenopathy, and peripheral blood mononucleosis.