DISEASE: Poor drug metabolism
Poor drug metabolism
Many administered drugs are first activated by phase I drug-metabolizing enzymes, such as cytochrome P450 (CYP). There are some defective activity mutants due to CYP polymorphisms. In these cases, drugs are not metabolized, the high drug levels in blood are maintained, and toxic effects appear in the patients.
Inherited metabolic disease
Human diseases [BR:
Congenital disorders of metabolism
Other congenital disorders of metabolism
H01171 Poor drug metabolism
Drug metabolism - cytochrome P450
In Caucasians and Asians, PM and allele frequency levels of CYPs (CYP2A6, CYP2C9, CYP2C19, CYP2D6, and CYP3A4) are summarized from previous findings.
PM frequencies of major CYPs in Asians and Caucasians.
Drug Metab Rev 35:99-106 (2003)
Gaikovitch EA, Cascorbi I, Mrozikiewicz PM, Brockmoller J, Frotschl R, Kopke K, Gerloff T, Chernov JN, Roots I
Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population.
Eur J Clin Pharmacol 59:303-12 (2003)
Kaneko A, Kaneko O, Taleo G, Bjorkman A, Kobayakawa T
High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu.
Lancet 349:921-2 (1997)
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