KEGG   DISEASE: Asthma with nasal polyps and aspirin intolerance
H01191                      Disease                                
Asthma with nasal polyps and aspirin intolerance
Asthma is a phenotypically heterogeneous disorder with many etiologic factors and clinical characteristics. In some patients with asthma, aspirin and all nonsteroidal anti-inflammatory drugs (NSAIDs) trigger asthmatic attacks. This clinical syndrome is characterized by eosinophilic inflammation of nasal and bronchial tissue, often associated with nasal polyps. It has been reported that genetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance.
Immune system disease
Human diseases in ICD-11 classification [BR:br08403]
 12 Diseases of the respiratory system
  Certain lower respiratory tract diseases
   CA23  Asthma
    H01191  Asthma with nasal polyps and aspirin intolerance
Pathway-based classification of diseases [BR:br08402]
 Cellular process
  nt06535  Efferocytosis
   H01191  Asthma with nasal polyps and aspirin intolerance
nt06535 Efferocytosis
TBX21 [HSA:30009] [KO:K10166]
PTGER2 [HSA:5732] [KO:K04259]
Other DBs
ICD-11: CA23.20
ICD-10: J45
MeSH: C565935
OMIM: 208550
Akahoshi M, Obara K, Hirota T, Matsuda A, Hasegawa K, Takahashi N, Shimizu M, Nakashima K, Cheng L, Doi S, Fujiwara H, Miyatake A, Fujita K, Higashi N, Taniguchi M, Enomoto T, Mao XQ, Nakashima H, Adra CN, Nakamura Y, Tamari M, Shirakawa T
Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.
Hum Genet 117:16-26 (2005)
Schaper C, Noga O, Koch B, Ewert R, Felix SB, Glaser S, Kunkel G, Gustavus B
Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis.
J Investig Allergol Clin Immunol 21:51-8 (2011)
Jinnai N, Sakagami T, Sekigawa T, Kakihara M, Nakajima T, Yoshida K, Goto S, Hasegawa T, Koshino T, Hasegawa Y, Inoue H, Suzuki N, Sano Y, Inoue I
Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach.
Hum Mol Genet 13:3203-17 (2004)

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