KEGG   DISEASE: Glomerulopathy with fibronectin deposits
Entry
H01260                      Disease                                
Name
Glomerulopathy with fibronectin deposits
Description
Glomerulopathy with fibronectin deposits (GFND) is a hereditary kidney disease with proteinuria, microscopic hematuria, and hypertension that lead to end-stage renal failure in the second to sixth decade of life. It has been reported that mutations in FN1, which encodes fibronectin, are the cause of GFND.
Category
Urinary system disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 21 Symptoms, signs or clinical findings, not elsewhere classified
  Symptoms, signs or clinical findings of the genitourinary system
   Clinical findings in specimens from the urinary system
    MF81  Fibronectin glomerulopathy
     H01260  Glomerulopathy with fibronectin deposits
Pathway-based classification of diseases [BR:br08402]
 Cellular process
  nt06539  Cytoskeleton in muscle cells
   H01260  Glomerulopathy with fibronectin deposits
Pathway
hsa04820 Cytoskeleton in muscle cells   
Network
nt06539 Cytoskeleton in muscle cells
Gene
FN1 [HSA:2335] [KO:K05717]
Other DBs
ICD-11: MF81
MeSH: C536826
OMIM: 601894
Reference
PMID:18268355
  Authors
Castelletti F, Donadelli R, Banterla F, Hildebrandt F, Zipfel PF, Bresin E, Otto E, Skerka C, Renieri A, Todeschini M, Caprioli J, Caruso RM, Artuso R, Remuzzi G, Noris M
  Title
Mutations in FN1 cause glomerulopathy with fibronectin deposits.
  Journal
Proc Natl Acad Sci U S A 105:2538-43 (2008)
DOI:10.1073/pnas.0707730105
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