KEGG   DISEASE: Nephrogenic syndrome of inappropriate antidiuresis
Entry
H01294                      Disease                                
Name
Nephrogenic syndrome of inappropriate antidiuresis
  Supergrp
Syndrome of inappropriate antidiuretic hormone secretion [DS:H01682]
Disorders of antidiuretic hormone (ADH) secretion [DS:H01683]
Description
Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a disorder of water balance caused by gain of function mutation of arginine vasopressin receptor type 2 (AVPR2) resulting in free water reabsorption and episodes of hyponatremia.
Category
Endocrine disease; Urinary system disease
Brite
Human diseases [BR:br08402]
 Endocrine and metabolic diseases
  Hypothalamus and pituitary gland diseases
   H01294  Nephrogenic syndrome of inappropriate antidiuresis
Human diseases in ICD-11 classification [BR:br08403]
 05 Endocrine, nutritional or metabolic diseases
  Endocrine diseases
   Disorders of the pituitary hormone system
    5A60  Hyperfunction of pituitary gland
     H01294  Nephrogenic syndrome of inappropriate antidiuresis
Related
pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04962  Vasopressin-regulated water reabsorption
Network
nt06326  AVP signaling
Gene
AVPR2 [HSA:554] [KO:K04228]
Other DBs
ICD-11: 5A60.20
ICD-10: E22.2
MeSH: C564491
OMIM: 300539
Reference
  Authors
Vandergheynst F, Brachet C, Heinrichs C, Decaux G
  Title
Long-term treatment of hyponatremic patients with nephrogenic syndrome of inappropriate antidiuresis: personal experience and review of published case reports.
  Journal
Nephron Clin Pract 120:c168-72 (2012)
DOI:10.1159/000338539
Reference
  Authors
Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL, Gitelman SE
  Title
Nephrogenic syndrome of inappropriate antidiuresis.
  Journal
N Engl J Med 352:1884-90 (2005)
DOI:10.1056/NEJMoa042743
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