Alkhumra hemorrhagic fever is a severe, often fatal, infectious disease caused by Alkhumra hemorrhagic fever virus (AHFV), a flavivirus in the Flaviviridae family of +ssRNA viruses, and transmitted by Ixodoidea ticks. AHFV was first isolated in 1994-1995 in the Al Khumra district, Jeddah, Saudi Arabia. Full genome sequencing has indicated that AHFV is a distinct variant of Kyasanur Forest disease virus.