Cache Valley virus infection is an infectious disease caused by Cache Valley virus (CVV), a mosquito-borne orthobunyavirus in the order Bunyavirales of -ssRNA viruses. CVV was first isolated in 1956 from Culiseta inornata mosquitoes in the Cache Valley of northern Utah. It circulates in mosquito and animal species across a large area of North, Central and South America. A limited number of human case reports have described severe illness.
