KEGG   DISEASE: Hereditary prostate cancer
Entry
H02530                      Disease                                
Name
Hereditary prostate cancer
  Supergrp
Prostate cancer [DS:H00024]
Description
Hereditary prostate cancer (HPC) has been used to characterize families with a particularly strong history of prostate cancer and includes those families with either: three or more affected first-degree relatives, prostate cancer diagnosed in three successive generations of the same lineage, or two first-degree relatives both diagnosed with early-onset disease. Familial cancer loci have been found, but the genes that cause familial prostate cancer remain largely elusive.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Cancers of male genital organs
   H02530  Hereditary prostate cancer
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of male genital organs
     2C82  Malignant neoplasms of prostate
      H02530  Hereditary prostate cancer
Gene
(HPC1) RNASEL [HSA:6041] [KO:K01165]
(HPC2) ELAC2 [HSA:60528] [KO:K00784]
(HPC9) HOXB13 [HSA:10481] [KO:K09298]
(HPC12) EHBP1 [HSA:23301] [KO:K25572]
(HPC13) MSMB [HSA:4477] [KO:K25684]
Other DBs
ICD-11: 2C82
ICD-10: C61
MeSH: C537243
OMIM: 601518 614731 610997 611868 611928
Reference
  Authors
Wiklund F, Jonsson BA, Brookes AJ, Stromqvist L, Adolfsson J, Emanuelsson M, Adami HO, Augustsson-Balter K, Gronberg H
  Title
Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer.
  Journal
Clin Cancer Res 10:7150-6 (2004)
DOI:10.1158/1078-0432.CCR-04-0982
Reference
  Authors
Rebbeck TR, Walker AH, Zeigler-Johnson C, Weisburg S, Martin AM, Nathanson KL, Wein AJ, Malkowicz SB
  Title
Association of HPC2/ELAC2 genotypes and prostate cancer.
  Journal
Am J Hum Genet 67:1014-9 (2000)
DOI:10.1086/303096
Reference
  Authors
Ewing CM, Ray AM, Lange EM, Zuhlke KA, Robbins CM, Tembe WD, Wiley KE, Isaacs SD, Johng D, Wang Y, Bizon C, Yan G, Gielzak M, Partin AW, Shanmugam V, Izatt T, Sinari S, Craig DW, Zheng SL, Walsh PC, Montie JE, Xu J, Carpten JD, Isaacs WB, Cooney KA
  Title
Germline mutations in HOXB13 and prostate-cancer risk.
  Journal
N Engl J Med 366:141-9 (2012)
DOI:10.1056/NEJMoa1110000
Reference
  Authors
Ao X, Liu Y, Bai XY, Qu X, Xu Z, Hu G, Chen M, Wu H
  Title
Association between EHBP1 rs721048(A>G) polymorphism and prostate cancer susceptibility: a meta-analysis of 17 studies involving 150,678 subjects.
  Journal
Onco Targets Ther 8:1671-80 (2015)
DOI:10.2147/OTT.S84034
Reference
  Authors
Lou H, Yeager M, Li H, Bosquet JG, Hayes RB, Orr N, Yu K, Hutchinson A, Jacobs KB, Kraft P, Wacholder S, Chatterjee N, Feigelson HS, Thun MJ, Diver WR, Albanes D, Virtamo J, Weinstein S, Ma J, Gaziano JM, Stampfer M, Schumacher FR, Giovannucci E, Cancel-Tassin G, Cussenot O, Valeri A, Andriole GL, Crawford ED, Anderson SK, Tucker M, Hoover RN, Fraumeni JF Jr, Thomas G, Hunter DJ, Dean M, Chanock SJ
  Title
Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility.
  Journal
Proc Natl Acad Sci U S A 106:7933-8 (2009)
DOI:10.1073/pnas.0902104106
Reference
  Authors
Giri VN, Beebe-Dimmer JL
  Title
Familial prostate cancer.
  Journal
Semin Oncol 43:560-565 (2016)
DOI:10.1053/j.seminoncol.2016.08.001
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