KEGG   DISEASE: Head and neck squamous cell carcinoma
Entry
H02610                      Disease                                
Name
Head and neck squamous cell carcinoma
Description
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world, affecting the pharynx, larynx and oral cavity. It is well known that smoking and alcohol abuse are major risk factors for HNSCC. Additionally, human papillomavirus infection is another implicated risk factor. Although lifestyle factors account for the majority of HNSCCs, genetic alterations will cause some individuals to be more sensitive to these environmental factors.
Category
Cancer
Brite
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasm metastases
    Malignant neoplasm metastasis in lymph nodes
     2D60  Malignant neoplasm metastasis in lymph node of a single region
      H02610  Head and neck squamous cell carcinoma
Pathway-based classification of diseases [BR:br08402]
 Cellular process
  nt06524  Apoptosis
   H02610  Head and neck squamous cell carcinoma
  nt06527  Necroptosis
   H02610  Head and neck squamous cell carcinoma
Pathway
hsa04210  Apoptosis
hsa04217  Necroptosis
Network
nt06524 Apoptosis
nt06527 Necroptosis
Gene
TNFRSF10B [HSA:8795] [KO:K04722]
ING1 [HSA:3621] [KO:K19197]
Other DBs
ICD-11: 2D60.0
MeSH: D000077195
OMIM: 275355
Reference
PMID:21052543
  Authors
Li X, Kikuchi K, Takano Y
  Title
ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma.
  Journal
J Oncol 2011:963614 (2011)
DOI:10.1155/2011/963614
Reference
PMID:23724937
  Authors
Tahir RA, Sehgal SA, Khattak NA, Khan Khattak JZ, Mir A
  Title
Tumor necrosis factor receptor superfamily 10B (TNFRSF10B): an insight from structure modeling to virtual screening for designing drug against head and neck  cancer.
  Journal
Theor Biol Med Model 10:38 (2013)
DOI:10.1186/1742-4682-10-38
Reference
PMID:9721851 (TNFRSF10B)
  Authors
Pai SI, Wu GS, Ozoren N, Wu L, Jen J, Sidransky D, El-Deiry WS
  Title
Rare loss-of-function mutation of a death receptor gene in head and neck cancer.
  Journal
Cancer Res 58:3513-8 (1998)
Reference
PMID:10866301 (ING1)
  Authors
Gunduz M, Ouchida M, Fukushima K, Hanafusa H, Etani T, Nishioka S, Nishizaki K, Shimizu K
  Title
Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.
  Journal
Cancer Res 60:3143-6 (2000)
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