| Description |
Mastocytosis is a rare myeloproliferative disease, characterized by excessive proliferation and accumulation of mast cells in the tissues. In cutaneous mastocytosis (MASTC), mast cells infiltration is limited to the skin, whereas in systemic mastocytosis internal organs are involved. MASTC is divided into three subtypes: maculopapular cutaneous mastocytosis, diffuse cutaneous mastocytosis, and mastocytoma of the skin. Mutations in KIT are observed in cutaneous mastocytosis. KIT encodes a type III transmembrane tyrosine kinase that is the receptor for stem cell factor.
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| Authors |
Bodemer C, Hermine O, Palmerini F, Yang Y, Grandpeix-Guyodo C, Leventhal PS, Hadj-Rabia S, Nasca L, Georgin-Lavialle S, Cohen-Akenine A, Launay JM, Barete S, Feger F, Arock M, Catteau B, Sans B, Stalder JF, Skowron F, Thomas L, Lorette G, Plantin P, Bordigoni P, Lortholary O, de Prost Y, Moussy A, Sobol H, Dubreuil P |
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| Authors |
Zhang LY, Smith ML, Schultheis B, Fitzgibbon J, Lister TA, Melo JV, Cross NC, Cavenagh JD |
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