L-ferritin deficiency (LFTD) is a rare genetic hematologic disease characterized by hypoferritinemia. Clinical symptoms include idiopathic generalized seizures and atypical restless legs syndrome. Asymptomatic cases have also been reported. Mutations in FTL have been reported causing LFTD. FTL encodes the L-ferritin subunit that helps with electron transport in and out of the ferritin core protein and plays a role in iron release.
