| 概要 |
Hereditary neutrophilia is a rare genetic immune disease characterized by chronic neutrophilia, increase in the percentage of circulating CD34+ cells in peripheral blood, increase in granulocyte precursors in bone marrow, and splenomegaly. It has been reported that an activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia. CSF3R encodes the granulocyte colony-stimulating factor (G-CSF) receptor which is involved in the differentiation and proliferation of granulocytes.
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| 著者 |
Plo I, Zhang Y, Le Couedic JP, Nakatake M, Boulet JM, Itaya M, Smith SO, Debili N, Constantinescu SN, Vainchenker W, Louache F, de Botton S |
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