KEGG   ORTHOLOGY: K00491
Entry
K00491                      KO                                     
Symbol
nos
Name
nitric-oxide synthase, bacterial [EC:1.14.14.47]
Pathway
map00220  Arginine biosynthesis
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K00491  nos; nitric-oxide synthase, bacterial
   00330 Arginine and proline metabolism
    K00491  nos; nitric-oxide synthase, bacterial
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.47  nitric-oxide synthase (flavodoxin)
     K00491  nos; nitric-oxide synthase, bacterial
Other DBs
RN: R11711 R11712 R11713
COG: COG4362
Genes
SCL: sce1582(nos)
SCU: SCE1572_10085
SDO: SD1155_11590
SAND: H3309_08495
BSU: BSU07630(nosA)
BSR: I33_0861
BSL: A7A1_0650
BSH: BSU6051_07630(nosA)
BSY: I653_03830
BSUT: BSUB_00838(nosA)
BSUL: BSUA_00838(nosA)
BSUS: Q433_04305
BSO: BSNT_07141(yflM)
BSQ: B657_07630(nosA)
BSX: C663_0787
BSS: BSUW23_03875(nosA)
BST: GYO_1029
BLI: BL03064(nos)
BLD: BLi00785(nos)
BLH: BaLi_c08860(nosA)
BAQ: BACAU_0755(nos)
BYA: BANAU_0700(yflM)
BAMP: B938_03755
BQY: MUS_0779(nos)
BAML: BAM5036_0694(nosA)
BAMA: RBAU_0759(nosA)
BAMN: BASU_0734(nosA)
BAMB: BAPNAU_0711(nos)
BAMT: AJ82_04375
BAMY: V529_07220(yflM)
BMP: NG74_00776(nos)
BAO: BAMF_0731(nos)
BAZ: BAMTA208_03465(nos)
BQL: LL3_00786(nos)
BXH: BAXH7_00731(yflM)
BAMI: KSO_015890
BAMC: U471_07660
BAMF: U722_03910
BMOJ: HC660_08120(nosA)
BAN: BA_5695
BAR: GBAA_5695
BAT: BAS5299
BAH: BAMEG_5743(nos)
BAI: BAA_5726(nos)
BANT: A16_57100
BANR: A16R_57790
BANS: BAPAT_5462
BANV: DJ46_4342(nos)
BCE: BC5444
BCA: BCE_5578
BCZ: BCE33L5141(nos)
BCR: BCAH187_A5626(nos)
BCG: BCG9842_B5379(nos)
BCQ: BCQ_5288(nos)
BCX: BCA_5597(nos)
BAL: BACI_c54380(nos)
BNC: BCN_5370
BCF: bcf_27340
BCER: BCK_08130
BTK: BT9727_5126(nos)
BTL: BALH_4953(nos)
BTT: HD73_5859
BTHI: BTK_28880
BTC: CT43_CH5486(nos)
BTM: MC28_4678
BTG: BTB_c56450(nos)
BTI: BTG_21155
BTW: BF38_1166(nos)
BWW: bwei_4336(nos)
BMYO: BG05_562
BMYC: DJ92_2532(nos)
BPU: BPUM_0714
BPUM: BW16_03800
BPUS: UP12_03895
BJS: MY9_0854
BACW: QR42_03710
BACP: SB24_05980
BACB: OY17_06555
BACY: QF06_02710
BACL: BS34A_08610(nosA)
BALM: BsLM_0801
BGY: BGLY_0801(nos)
BFD: NCTC4823_03517(nos)
BMQ: BMQ_0362(nos)
BMD: BMD_0363(nos)
BMH: BMWSH_4868(nos)
BMEG: BG04_2652(nos)
BEO: BEH_02605
BHA: BH0823
BCL: ABC1267
BKW: BkAM31D_03290(nos)
BPF: BpOF4_10365(nos)
OIH: OB2691
GKA: GK1676
GGH: GHH_c16880(nos)
GEA: GARCT_01674(nos)
AFL: Aflv_0298
ANM: GFC28_2167(nos)
AAMY: GFC30_793(nos)
ANL: GFC29_3269(nos)
LSP: Bsph_0728
HHD: HBHAL_1332(nos)
HLI: HLI_09830
VPN: A21D_02524(nos)
PASA: BAOM_2909
PSYO: PB01_07055
BBEV: BBEV_2376(nos)
BSE: Bsel_2946
SAU: SA1730
SAV: SAV1914
SAW: SAHV_1899
SAM: MW1855
SAS: SAS1838
SAR: SAR2007
SAC: SACOL1976
SAE: NWMN_1852
SAD: SAAV_1981
SUE: SAOV_2017
SUZ: MS7_1949(nos)
SUG: SAPIG2009
SAUA: SAAG_02434
SAUE: RSAU_001801(nos)
SAUS: SA40_1755
SAUU: SA957_1839
SAUG: SA268_1911
SAUV: SAI7S6_1014530(nos)
SAUW: SAI5S5_1014470(nos)
SAUX: SAI6T6_1014490(nos)
SAUY: SAI8T7_1014510(nos)
SAUF: X998_1969
SAB: SAB1851
SAUB: C248_1990
SAUC: CA347_2003(nos)
SAUR: SABB_02339(nos)
SAUI: AZ30_10205
SAUD: CH52_09350
SER: SERP1451
SEP: SE_1598
SEPP: SEB_01584
SEPS: DP17_542(nos)
SHA: SH1038
SSP: SSP0877
SCA: SCA_1487(nos)
SDT: SPSE_0828(nos)
SDP: NCTC12225_00897(nos)
SPAS: STP1_0432
SXO: SXYL_00923(nos)
SHU: SHYC_04255(nos)
SCAP: AYP1020_1191(nos)
SSCH: LH95_04145
SSCZ: RN70_04365
SAGQ: EP23_05735
SARL: SAP2_09410
SPIC: SAMEA4384060_1034(nos)
SSH: NCTC13712_01935(nos)
SSIM: SAMEA4384339_1835(nos)
SSTE: SAMEA4384403_0769(nos)
MCL: MCCL_1651
MCAK: MCCS_21100(nos)
LGZ: NCTC10812_01779(nos)
ESI: Exig_0344
EAN: Eab7_0319(nos)
BBE: BBR47_57280(nos)
PPY: PPE_04584
PPM: PPSC2_23875(nos)
PPO: PPM_4742(nos)
PPOL: X809_40430
PPOY: RE92_13380
PLV: ERIC2_c17570(nos)
PSWU: SY83_12360
PBK: Back11_50640(nos)
PALO: E6C60_2805
AAC: Aaci_2338
AAD: TC41_2620(nos)
SIV: SSIL_3667
JEO: JMA_12200
KZO: NCTC404_00623(nos)
NAD: NCTC11293_00971(nos)
RHA: RHA1_ro02793(nos)
RER: RER_13870(nos)
REY: O5Y_06535
ROP: ROP_24100(nos)
SMA: SAVERM_1531(nos)
SCB: SCAB_31841(txtD)
SVE: SVEN_6572
STRD: NI25_07315
SLX: SLAV_32220(nos)
SNF: JYK04_01525(nos)
SRO: Sros_2358
NCX: Nocox_11290(nos)
NML: Namu_4253
SEN: SACE_5845(nos) SACE_7255(nos)
SACC: EYD13_10075(nos)
AMD: AMED_4154(nos)
AMN: RAM_21160
AMM: AMES_4106(nos)
AMZ: B737_4106(nos)
AOI: AORI_5274(nos)
AMYY: YIM_18920(nos)
AORI: SD37_15645
PDX: Psed_6636
PSEA: WY02_16105
PSEE: FRP1_26655
PSEH: XF36_27440
PAUT: Pdca_67640
AMI: Amir_1303
SESP: BN6_15480 BN6_84360(nos)
AHG: AHOG_18745(nos1) AHOG_27320(nos2)
SAQ: Sare_3563
ASE: ACPL_7469(nos)
ACTN: L083_4136(nos)
AFS: AFR_37445
ACTS: ACWT_7339
AIH: Aiant_33090(nos)
PSUU: Psuf_019840(nos)
CAI: Caci_1733
DRA: DR_2597
DGE: Dgeo_0268
DGO: DGo_CA2502(nos)
DGA: DEGR_01200(nos)
CPRV: CYPRO_2999
HARA: AArcS_0612
NPH: NP_1908A(nos)
 » show all
Reference
  Authors
Adak S, Aulak KS, Stuehr DJ
  Title
Direct evidence for nitric oxide production by a nitric-oxide synthase-like protein from Bacillus subtilis.
  Journal
J Biol Chem 277:16167-71 (2002)
DOI:10.1074/jbc.M201136200
  Sequence
[bsu:BSU07630]
Reference
  Authors
Gusarov I, Starodubtseva M, Wang ZQ, McQuade L, Lippard SJ, Stuehr DJ, Nudler E
  Title
Bacterial nitric-oxide synthases operate without a dedicated redox partner.
  Journal
J Biol Chem 283:13140-7 (2008)
DOI:10.1074/jbc.M710178200
LinkDB

KEGG   ENZYME: 1.14.14.47
Entry
EC 1.14.14.47               Enzyme                                 
Name
nitric-oxide synthase (flavodoxin);
nitric oxide synthetase (ambiguous);
NO synthase (ambiguous)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
L-arginine,reduced-flavodoxin:oxygen oxidoreductase (nitric-oxide-forming)
Reaction(IUBMB)
2 L-arginine + 3 reduced flavodoxin + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 oxidized flavodoxin + 4 H2O (overall reaction) [RN:R11711];
(1a) 2 L-arginine + 2 reduced flavodoxin + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 oxidized flavodoxin + 2 H2O  [RN:R11712];
(1b) 2 Nomega-hydroxy-L-arginine + reduced flavodoxin + 2 O2 = 2 L-citrulline + 2 nitric oxide + oxidized flavodoxin + 2 H2O [RN:R11713]
Reaction(KEGG)
Substrate
L-arginine [CPD:C00062];
reduced flavodoxin [CPD:C02745];
O2 [CPD:C00007];
Nomega-hydroxy-L-arginine [CPD:C05933]
Product
L-citrulline [CPD:C00327];
nitric oxide [CPD:C00533];
oxidized flavodoxin [CPD:C02869];
H2O [CPD:C00001];
Nomega-hydroxy-L-arginine [CPD:C05933]
Comment
Binds heme (iron protoporphyrin IX) and tetrahydrobiopterin. The enzyme, found in bacteria and archaea, consist of only an oxygenase domain and functions together with bacterial ferredoxins or flavodoxins. The orthologous enzymes from plants and animals also contain a reductase domain and use only NADPH as the electron donor (cf. EC 1.14.13.39).
History
EC 1.14.14.47 created 2012 as EC 1.14.13.165, transferred 2017 to EC 1.14.14.47
Pathway
ec00220  Arginine biosynthesis
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K00491  nitric-oxide synthase, bacterial
Genes
SCLsce1582(nos)
SCUSCE1572_10085
SDOSD1155_11590
SANDH3309_08495
BSUBSU07630(nosA)
BSRI33_0861
BSLA7A1_0650
BSHBSU6051_07630(nosA)
BSYI653_03830
BSUTBSUB_00838(nosA)
BSULBSUA_00838(nosA)
BSUSQ433_04305
BSOBSNT_07141(yflM)
BSNBSn5_15720
BSQB657_07630(nosA)
BSXC663_0787
BSPU712_03875
BSSBSUW23_03875(nosA)
BSTGYO_1029
BLIBL03064(nos)
BLDBLi00785(nos)
BLHBaLi_c08860(nosA)
BAYRBAM_007830
BAQBACAU_0755(nos)
BYABANAU_0700(yflM)
BAMPB938_03755
BQYMUS_0779(nos)
BAMLBAM5036_0694(nosA)
BAMARBAU_0759(nosA)
BAMNBASU_0734(nosA)
BAMBBAPNAU_0711(nos)
BAMTAJ82_04375
BAMYV529_07220(yflM)
BMPNG74_00776(nos)
BAOBAMF_0731(nos)
BAZBAMTA208_03465(nos)
BQLLL3_00786(nos)
BXHBAXH7_00731(yflM)
BAMIKSO_015890
BAMCU471_07660
BAMFU722_03910
BSIACWD84_18155
BAEBATR1942_01420
BVMB9C48_03855
BSONS101395_00981
BHTDIC78_05955
BMOJHC660_08120(nosA)
BTEQG4P54_04000
BIQAN935_03985
BANBA_5695
BARGBAA_5695
BATBAS5299
BAHBAMEG_5743(nos)
BAIBAA_5726(nos)
BAXH9401_5438
BANTA16_57100
BANRA16R_57790
BANSBAPAT_5462
BANHHYU01_27800
BANVDJ46_4342(nos)
BCEBC5444
BCABCE_5578
BCZBCE33L5141(nos)
BCRBCAH187_A5626(nos)
BCBBCB4264_A5570
BCUBCAH820_5540
BCGBCG9842_B5379(nos)
BCQBCQ_5288(nos)
BCXBCA_5597(nos)
BALBACI_c54380(nos)
BNCBCN_5370
BCFbcf_27340
BCERBCK_08130
BCEFBcrFT9_04373
BCYBcer98_3961
BTKBT9727_5126(nos)
BTLBALH_4953(nos)
BTTHD73_5859
BTHRYBT1520_29025
BTHIBTK_28880
BTCCT43_CH5486(nos)
BTFYBT020_27155
BTMMC28_4678
BTGBTB_c56450(nos)
BTIBTG_21155
BTNBTF1_25715
BTHTH175_ch5579
BTHUYBT1518_30590
BTWBF38_1166(nos)
BTHYAQ980_02070
BWEBcerKBAB4_5238
BWWbwei_4336(nos)
BMYOBG05_562
BTYBtoyo_2641
BMYCDJ92_2532(nos)
BBYCY96_26345
BWDCT694_29235
BTROFJR70_21385
BMOBMLA2C4_28200
BNTGSN03_26080
BPACLMD38_26605
BPUBPUM_0714
BPUMBW16_03800
BPUSUP12_03895
BJSMY9_0854
BACIB1NLA3E_08360
BIFN288_20625
BACWQR42_03710
BACPSB24_05980
BACBOY17_06555
BACYQF06_02710
BACLBS34A_08610(nosA)
BALMBsLM_0801
BGYBGLY_0801(nos)
BWHA9C19_17395
BXIBK049_04380
BALTCFN77_03755
BACSAUL54_06935
BSAFBSL056_03725
BITBIS30_14420
BACQDOE78_14780
BFDNCTC4823_03517(nos)
BDAFSZ17_04725
BSHILGQ02_04140
BBADK7T73_03130
BCOBcell_0737
BHKB4U37_04205
BCOHBC6307_01055
BMQBMQ_0362(nos)
BMDBMD_0363(nos)
BMHBMWSH_4868(nos)
BMEGBG04_2652(nos)
BEOBEH_02605
BFXBC359_19175
PKSIE339_02295
BHABH0823
BCLABC1267
BLEBleG1_1155
BKWBkAM31D_03290(nos)
BGIBGM20_19000
BPFBpOF4_10365(nos)
BONA361_11620
BKOCKF48_00025
CGOTJ1899_10335
OIHOB2691
GKAGK1676
GTEGTCCBUS3UF5_19370
GTKGT3570_08055
GTMGT3921_11065
GLIGLN3_01685
GYCGYMC61_2511
GYAGYMC52_1640
GCTGC56T3_1838
GGHGHH_c16880(nos)
GEAGARCT_01674(nos)
GELIB49_00320
GSEGT50_17555
GSRGS3922_08220
GZAIC807_04430
AFLAflv_0298
AGNAFK25_01650
ANMGFC28_2167(nos)
AAMYGFC30_793(nos)
ANLGFC29_3269(nos)
ANDGRQ40_02370
ACAIISX45_17805
LSPBsph_0728
LGYT479_01060
LFUHR49_22620
LYSLBYS11_01390
LYBC3943_01540
LYZDCE79_01140
LYGC1N55_00885
LPAKGDS87_01420
LAGRFJQ98_01270
LMACI6G82_17165
HHDHBHAL_1332(nos)
HMNHM131_19595
HLIHLI_09830
TAPGZ22_17055
TAIDKS242_12610
VHLBME96_02640
VIGBKP57_16635
VPNA21D_02524(nos)
VPTKBP50_13320
FPNABE65_010735
FARABE41_006800
SJEAAV35_008390
BSJUP17_13510
BMURABE28_012715
PBUTDTO10_00960
PASABAOM_2909
PPSRI6J18_13220
PSYHD0S48_04350
PSYOPB01_07055
POFGS400_16275
NMKCHR53_26620
NTMBTDUT50_00060
MSEMGMB29_02290
MDGK8L98_03050
SEDDERJ70_06865
BVQFHE72_03110
RMFD5E69_03015
BOUI5818_03190
CTHUHUR95_05300
BBEVBBEV_2376(nos)
BSEBsel_2946
MCUIG8O30_01540
GAJMY490_04670
SAUSA1730
SAVSAV1914
SAWSAHV_1899
SAHSaurJH1_2004
SAJSaurJH9_1970
SAMMW1855
SASSAS1838
SARSAR2007
SACSACOL1976
SAXUSA300HOU_1916
SAASAUSA300_1895
SAOSAOUHSC_02134
SAENWMN_1852
SADSAAV_1981
SUUM013TW_1951
SUVSAVC_08835
SUESAOV_2017
SUJSAA6159_01846
SUKSAA6008_01935
SUCECTR2_1786
SUTSAT0131_02042
SUQHMPREF0772_11227
SUZMS7_1949(nos)
SUDST398NM01_2009
SUXSAEMRSA15_18240
SUWSATW20_19090
SUGSAPIG2009
SUFSARLGA251_17990
SAUASAAG_02434
SAUERSAU_001801(nos)
SAUNSAKOR_01877
SAUSSA40_1755
SAUUSA957_1839
SAUGSA268_1911
SAUZSAZ172_1927
SAUTSAI1T1_2014520
SAUJSAI2T2_1014530
SAUKSAI3T3_1014520
SAUQSAI4T8_1014530
SAUVSAI7S6_1014530(nos)
SAUWSAI5S5_1014470(nos)
SAUXSAI6T6_1014490(nos)
SAUYSAI8T7_1014510(nos)
SAUFX998_1969
SABSAB1851
SUYSA2981_1871
SAUBC248_1990
SAUMBN843_19540
SAUCCA347_2003(nos)
SAURSABB_02339(nos)
SAUIAZ30_10205
SAUDCH52_09350
SUHSAMSHR1132_17590
SERSERP1451
SEPSE_1598
SEPPSEB_01584
SEPSDP17_542(nos)
SHASH1038
SHHShL2_00926
SSPSSP0877
SCASCA_1487(nos)
SLGSLGD_01013
SLNSLUG_10520
SSDSPSINT_1667
SDTSPSE_0828(nos)
SDPNCTC12225_00897(nos)
SWAA284_04430
SPASSTP1_0432
SXYBE24_07485
SXLSXYLSMQ121_0914
SXOSXYL_00923(nos)
SHUSHYC_04255(nos)
SCAPAYP1020_1191(nos)
SSCHLH95_04145
SSCZRN70_04365
SAGQEP23_05735
SEQOSE1039_17010
SSIFAL483_02365
SCVA4G25_12630
SPETCEP67_04005
SLZB5P37_02025
SCOHBZ166_08845
SNLBJD96_04810
SKLC7J89_05920
SFQC7J90_11510
SHOMEGX58_08565
SMUSC7J88_04285
SCARDWB96_04740
SCHRDWB92_04175
SARLSAP2_09410
SPICSAMEA4384060_1034(nos)
SSHNCTC13712_01935(nos)
SSIMSAMEA4384339_1835(nos)
SDBCNQ82_09405
SLLOISP08_04585
SSCUCEP64_03420
SFFFOB90_03675
SSTESAMEA4384403_0769(nos)
MLENH3V22_04930
MVTI6J10_07325
MCLMCCL_1651
MCAKMCCS_21100(nos)
MACRBHM04_00405
MBOEHT586_10280
MARYLAU42_09725
NAMPKPF49_07805
LWIUE46_15835
LGZNCTC10812_01779(nos)
BTHSCNY62_08175
ESIExig_0344
EATEAT1b_1019
EANEab7_0319(nos)
EXMU719_01775
EXUESP131_04215
EAPKB235_05450
EACEKKI46_02030
BBEBBR47_57280(nos)
BFMBP422_24185
BAGRBA6348_03800
BCHSJNE38_29990
BCOPJD108_11655
PJDPjdr2_3338
GYMGYMC10_4638
PPYPPE_04584
PPMPPSC2_23875(nos)
PPOPPM_4742(nos)
PPOLX809_40430
PPQPPSQR21_048330
PPOYRE92_13380
PTAHPL003_05435
PLVERIC2_c17570(nos)
PODPODO_29720
PAEFR50345_29825
PAEJH70737_29465
PIHUB51_20670
PPEOABE82_24070
PNPIJ22_16130
POWIJ21_22840
PBVAR543_00515
PXLBS614_00925
PSWUSY83_12360
PIBBBD41_00125
PKBB4V02_01375
PVOPVOR_24934
PLWD5F53_06995
PPSCEHS13_34415
PLUTEI981_21220
PALBEJC50_02535
PCHIPC41400_07330
PBKBack11_50640(nos)
PPRTET464_04185
PBACHUB98_15100
PRZGZH47_17490
PLYCGXP70_28985
PTRIKDC22_31800
PALOE6C60_2805
PCELHUB94_17955
PALRHGI30_11900
COHNKCTCHS21_31900
CCHLFPL14_28765
AACAaci_2338
AADTC41_2620(nos)
SIVSSIL_3667
SSILSOLI23_00045
SOBCSE16_01305
PLNPlano_2573
PRTAUC31_13130
PANABBH88_05875
PDGBCM40_02230
PHCBBI08_10265
PMARB0X71_01000
PPLABBI15_09170
PFAEAJGP001_14895
PLXCW734_15225
PMATBBI11_14730
PDECH1Q58_14045
JEOJMA_12200
KURASO14_2744
KZONCTC404_00623(nos)
SPSYAZE41_10350
SPOSDV702_12015
RSTATY39_15805
PAEKD3873_11545
PANCE2636_03920
PLAYDNR44_006850
VIJJNUCC6_16315
LFBC1X05_14575
NBRO3I_000985
NSLBOX37_01030
NTPCRH09_20790
NOZDMB37_22015
NODFOH10_11235
NAHF5544_01115
NADNCTC11293_00971(nos)
NIEKV110_00965
NTCKHQ06_36635
NGPLTT66_13825 LTT66_14690
RHARHA1_ro02793(nos)
RERRER_13870(nos)
REYO5Y_06535
REBXU06_06795
RQIC1M55_07040
ROPROP_24100(nos)
ROAPd630_LPD06889
RHWBFN03_19375
RHODAOT96_17435
RKOJWS14_14015
RGOKYT97_11625
SPINKV203_18065
SMASAVERM_1531(nos)
SCBSCAB_31841(txtD)
SVESVEN_6572
SGUSGLAU_31445
SVTSVTN_35450
SXISXIM_27790
STRMM444_05170 M444_06580
SCXAS200_14345
SGSAVL59_27975
STRDNI25_07315
SPUNBFF78_07785
SLXSLAV_32220(nos)
SLKSLUN_05265
SDXC4B68_35890
STIRDDW44_01525
SGZC0216_19050
SVNCP980_29195
SRKFGW37_30405
SSPODDQ41_10305
SVRCP971_05395 CP971_07990
SFYGFH48_35685
SSUBCP968_29190
SCINCP977_31915
SGXH4W23_13075
SNFJYK04_01525(nos)
SBROGQF42_36740
SATAC5746_05230
SHARHUT13_14490
SLIAHA039_32420
KAUB6264_00800
KITCFP65_6445
ACITHPK19_22905
NOYEXE57_18045
KQIF1D05_05085
SROSros_2358
NOABKM31_09450 BKM31_32400
NOWGBF35_12115
NCXNocox_11290(nos)
NGNLCN96_12835 LCN96_31860
NMLNamu_4253
SENSACE_5845(nos) SACE_7255(nos)
SACCEYD13_10075(nos)
AMDAMED_4154(nos)
AMNRAM_21160
AMMAMES_4106(nos)
AMZB737_4106(nos)
AOIAORI_5274(nos)
AJAAJAP_24070
AMYBBKN51_07465
AMYYYIM_18920(nos)
AORISD37_15645
PDXPsed_6636
PSEAWY02_16105
PSEEFRP1_26655
PSEHXF36_27440
PSEQAD006_05840
PECQAD017_13660
PHHAFB00_11435
PAUTPdca_67640
PBROHOP40_09440
APRECNX65_06450
AMIAmir_1303
SESPBN6_15480 BN6_84360(nos)
SSYIEKG83_07520 EKG83_46180
KALKALB_6966 KALB_8739
KPHYAOZ06_05175 AOZ06_41055 AOZ06_46845 AOZ06_51945 AOZ06_52570
LEDBBK82_02920 BBK82_14965
AHMTL08_17805 TL08_26260
ACTIUA75_21735 UA75_30065
ACADUA74_21255 UA74_29535
AHGAHOG_18745(nos1) AHOG_27320(nos2)
ACTAC1701_04210
ALOCRK56245 CRK60627
SACEGIY23_16395
SAQSare_3563
MICHFJK98_17595
MCABHXZ27_19545
ASEACPL_7469(nos)
AMSAMIS_72150
ACTNL083_4136(nos)
AFSAFR_37445
ACTSACWT_7339
AIHAiant_33090(nos)
PSUUPsuf_019840(nos)
PRYPrubr_36930(nos) Prubr_37480
CATICS0771_26370
DVCDvina_45575
CAICaci_1733
MICMic7113_5682
CEPCri9333_1836
ANBANA_C10702
DRADR_2597
DGEDgeo_0268
DDRDeide_13130
DMRDeima_0688
DPTDeipr_0530
DGODGo_CA2502(nos)
DPDDeipe_2456
DCHSY84_09620
DABAUC44_00625
DEZDKM44_03340
DWUDVJ83_10815
DGADEGR_01200(nos)
DRDLMT64_01325
LAMBKBB96_12895
ALMAO498_03375
CPRVCYPRO_2999
HARAAArcS_0612
NPHNP_1908A(nos)
HALIBV210_01495
NGENatgr_2846
NAJB1756_12305
NAGAArcMg_0534
NANAArc1_0547
 » show all
Reference
1  [PMID:12220171]
  Authors
Pant K, Bilwes AM, Adak S, Stuehr DJ, Crane BR
  Title
Structure of a nitric oxide synthase heme protein from Bacillus subtilis.
  Journal
Biochemistry 41:11071-9 (2002)
DOI:10.1021/bi0263715
  Sequence
[bsu:BSU07630]
Reference
2  [PMID:11856757]
  Authors
Adak S, Aulak KS, Stuehr DJ
  Title
Direct evidence for nitric oxide production by a nitric-oxide synthase-like protein from Bacillus subtilis.
  Journal
J Biol Chem 277:16167-71 (2002)
DOI:10.1074/jbc.M201136200
Reference
3  [PMID:17127770]
  Authors
Wang ZQ, Lawson RJ, Buddha MR, Wei CC, Crane BR, Munro AW, Stuehr DJ
  Title
Bacterial flavodoxins support nitric oxide production by Bacillus subtilis nitric-oxide synthase.
  Journal
J Biol Chem 282:2196-202 (2007)
DOI:10.1074/jbc.M608206200
Reference
4  [PMID:19805284]
  Authors
Agapie T, Suseno S, Woodward JJ, Stoll S, Britt RD, Marletta MA
  Title
NO formation by a catalytically self-sufficient bacterial nitric oxide synthase from Sorangium cellulosum.
  Journal
Proc Natl Acad Sci U S A 106:16221-6 (2009)
DOI:10.1073/pnas.0908443106
Reference
5  [PMID:25194416]
  Authors
Holden JK, Lim N, Poulos TL
  Title
Identification of redox partners and development of a novel chimeric bacterial nitric oxide synthase for structure activity analyses.
  Journal
J Biol Chem 289:29437-45 (2014)
DOI:10.1074/jbc.M114.595165
  Sequence
[bsu:BSU07630]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.47
IUBMB Enzyme Nomenclature: 1.14.14.47
ExPASy - ENZYME nomenclature database: 1.14.14.47
BRENDA, the Enzyme Database: 1.14.14.47
LinkDB

KEGG   REACTION: R11711
Entry
R11711                      Reaction                               
Name
L-arginine,reduced-flavodoxin:oxygen oxidoreductase (nitric-oxide-forming)
Definition
2 L-Arginine + 3 Reduced flavodoxin + 4 Oxygen <=> 2 L-Citrulline + 2 Nitric oxide + 3 Oxidized flavodoxin + 4 H2O
Equation
2 C00062 + 3 C02745 + 4 C00007 <=> 2 C00327 + 2 C00533 + 3 C02869 + 4 C00001
Comment
two-step reaction (see R11712+R11713)
Reaction class
RC00177  C00062_C00327
Enzyme
Pathway
rn00220  Arginine biosynthesis
rn01100  Metabolic pathways
Orthology
K00491  nitric-oxide synthase, bacterial [EC:1.14.14.47]
Other DBs
RHEA: 52327
LinkDB

DBGET integrated database retrieval system