KEGG ORTHOLOGY: K01296

ORTHOLOGY: K01296

Entry

K01296                      KO

Symbol

CPM

Name

carboxypeptidase M [EC:3.4.17.12]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01296  CPM; carboxypeptidase M
  09183 Protein families: signaling and cellular processes
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins
    K01296  CPM; carboxypeptidase M
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.17  Metallocarboxypeptidases
    3.4.17.12  carboxypeptidase M
     K01296  CPM; carboxypeptidase M
Peptidases and inhibitors [BR:ko01002]
Metallo peptidases
  Family M14: carboxypeptidase A family
   K01296  CPM; carboxypeptidase M
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537]
Enzymes
  K01296  CPM; carboxypeptidase M

Other DBs

GO:

0004181

Genes

HSA:

1368(CPM)

PTR:	452067(CPM)

PPS:	100969689(CPM)

GGO:	101130328(CPM)

PON:	100171502(CPM)

PPYG:

129009952(CPM)

NLE:	100602479(CPM)

HMH:	116478989(CPM)

SSYN:

129461022(CPM)

MCC:	718315(CPM)

MCF:	102138123(CPM)

MTHB:

126931706

MNI:	105473402(CPM)

CSAB:

103238691(CPM)

CATY:

105580996(CPM)

PANU:

101018002(CPM)

TGE:	112634275(CPM)

MLEU:

105537116(CPM)

RRO:	104658666(CPM)

RBB:	108532256(CPM)

TFN:	117089768(CPM)

PTEH:

111528611(CPM)

CANG:

105502660(CPM)

CJC:	100410597(CPM)

SBQ:	101040778(CPM)

CIMI:

108315987(CPM)

ANAN:

105709494(CPM)

CSYR:

103269050(CPM)

MMUR:

105884628(CPM)

LCAT:

123639533(CPM)

PCOQ:

105808419(CPM)

OGA:	100959155(CPM)

MMU:	70574(Cpm)

MCAL:

110304045(Cpm)

MPAH:

110326791(Cpm)

RNO:	314855(Cpm)

MCOC:

116076314(Cpm)

ANU:	117696799(Cpm)

ASYL:

127671272(Cpm)

MUN:	110562244(Cpm)

CGE:	100770407(Cpm)

MAUA:

101832744(Cpm)

PROB:

127215728(Cpm)

PLEU:

114693315(Cpm)

MORG:

121458191(Cpm)

MFOT:

126515658

AAMP:

119803443(Cpm)

NGI:	103745080(Cpm)

HGL:	101724468(Cpm)

CPOC:

100732968(Cpm)

CCAN:

109693329(Cpm)

DORD:

105986885(Cpm)

DSP:	122124079(Cpm)

PLOP:

125361421(Cpm)

NCAR:

124983196

MMMA:

107140072(Cpm)

ITI:	101958492(Cpm)

OCU:	100349485 108176913

OPI:	101519258(CPM)

TUP:	102474632(CPM)

GVR:	103601366(CPM)

CFA:	100685525(CPM)

CLUD:

112677879(CPM)

VVP:	112922195(CPM)

VLG:	121491248(CPM)

NPO:	129511630(CPM)

AML:	100481997(CPM)

UMR:	103656872(CPM)

UAH:	113256293(CPM)

UAR:	123787143(CPM)

ELK:

111142131

LLV:

125107552

MPUF:

101689497(CPM)

MNP:	132019433(CPM)

MLK:	131839137(CPM)

NVS:	122891706(CPM)

ORO:	101386105(CPM)

EJU:	114214944(CPM)

ZCA:	113921845(CPM)

MLX:	118008588(CPM)

NSU:	110570610(CPM)

LWW:	102730370(CPM)

FCA:	101097407(CPM)

PYU:	121040768(CPM)

PCOO:

112863821(CPM)

PBG:	122474008(CPM)

PVIV:

125170534(CPM)

LRUF:

124501297

LGF:	123591365(CPM)

AJU:

106966349

PTG:	102967223(CPM)

PPAD:

109270485(CPM)

PUC:

125919326

PLEZ:

122224814(CPM)

HHV:	120240804(CPM)

BTA:	513281(CPM)

BOM:	102287201(CPM)

BIU:	109559246(CPM)

BBUB:

102402297(CPM)

BBIS:

104989768(CPM)

CHX:	102172872(CPM)

OAS:	101104474(CPM)

BTAX:

128047456(CPM)

CSUM:

138078473(CPM)

ODA:	120857721(CPM)

CCAD:

122427263(CPM)

MREE:

136167227(CPM)

OVR:	110134340(CPM)

MBEZ:

129535572(CPM)

SSC:	100628221(CPM)

CFR:	102522173(CPM)

CBAI:

105081335(CPM)

CDK:	105101084(CPM)

VPC:	102538081(CPM)

BACU:

103017503(CPM)

BMUS:

118901991(CPM)

LVE:	103081156(CPM)

OOR:	101286496(CPM)

LALB:

132529134(CPM)

DLE:	111173760(CPM)

PCAD:

102992832(CPM)

PSIU:

116761019(CPM)

NASI:

112393947(CPM)

ECB:	100059473(CPM)

EPZ:	103558164(CPM)

EAI:	106843580(CPM)

MYB:	102256624(CPM)

MYD:	102770875(CPM)

MMYO:

118650129(CPM)

MLF:	102420573(CPM)

MDT:	132227908(CPM)

MYUM:

139006926(CPM)

PKL:	118729243(CPM)

EFUS:

103292524(CPM)

MNA:	107526849(CPM)

DRO:	112318964(CPM)

SHON:

118989365(CPM)

AJM:	119052718(CPM)

PDIC:

114514175(CPM)

PHAS:

123812982(CPM)

MMF:	118624621(CPM)

PPAM:

129075870(CPM)

HAI:	109381649(CPM)

RFQ:	117029273(CPM)

PALE:

102884706(CPM)

PGIG:

120605044(CPM)

PVP:	105301351(CPM)

RAY:	107512675(CPM)

MJV:	108394492(CPM)

TOD:	119247527(CPM)

SARA:

101546949(CPM)

SFUM:

130038964(CPM)

SETR:

126021880(CPM)

LAV:	100665759(CPM)

TMU:

101349661

ETF:	101658120(CPM)

DNM:	101417155(CPM)

MDO:	100021372(CPM)

GAS:	123248978(CPM)

SHR:	100921178(CPM)

AFZ:

127564479

PCW:	110211047(CPM)

TVP:	118850283(CPM)

PBRV:

138155888(CPM)

OAA:	100080749(CPM)

TACU:

119936584(CPM)

GGA:	417843(CPM)

PCOC:

116226593(CPM)

MGP:	100543962(CPM)

CJO:	107310518(CPM)

TPAI:

128073881(CPM)

LMUT:

125688067(CPM)

NMEL:

110392788(CPM)

APLA:

101789743(CPM)

ACYG:

106045412(CPM)

CATA:

118246863(CPM)

AFUL:

116494980(CPM)

TGU:	100225708(CPM)

LSR:	110477994(CPM)

SCAN:

103813678(CPM)

PMOA:

120499768(CPM)

OTC:	121339479(CPM)

PRUF:

121352550(CPM)

ATRC:

139588294(CPM)

GFR:	102037874(CPM)

FAB:	101813399(CPM)

OMA:	130248664(CPM)

PHI:	102101701(CPM)

PMAJ:

107204719(CPM)

CCAE:

111937509(CPM)

CCW:	104698374(CPM)

CBRC:

103614884(CPM)

ACOE:

138100952(CPM)

ETL:	114062166(CPM)

ZAB:	102062686(CPM)

ZLE:	135442282(CPM)

ACHL:

103799311(CPM)

SVG:	106855282(CPM)

MMEA:

130580185(CPM)

HRT:	120751368(CPM)

SATI:

136361329(CPM)

CCIC:

134043102(CPM)

FPG:	101923955(CPM)

FCH:	102048341(CPM)

CCRI:

104168814(CPM)

NNT:	104410548(CPM)

SHAB:

115605368(CPM)

ACUN:

113491126(CPM)

TALA:

104366267(CPM)

ACHC:

115336120(CPM)

HALD:

104318062(CPM)

HLE:	104828225(CPM)

AGEN:

126034596

HHAR:

128135336(CPM)

GCL:

127020593

CSTI:

104558168(CPM)

LDI:	104344818(CPM)

MNB:	103769979(CPM)

DPUB:

104305551(CPM)

PPUS:

135187289(CPM)

AVIT:

104274688(CPM)

BRHI:

104493673(CPM)

EGZ:	104132947(CPM)

NNI:	104011003(CPM)

PCRI:

104032000(CPM)

PCAO:

104047942(CPM)

PADL:

103920039(CPM)

AFOR:

103893924(CPM)

FGA:	104074509(CPM)

GSTE:

104264417(CPM)

CBOY:

140658948(CPM)

CLV:	102085565(CPM)

MUI:	104538984(CPM)

PGUU:

104471926(CPM)

PLET:

104625311(CPM)

EHS:	104515221(CPM)

CMAC:

104483892(CPM)

CUCA:

104061313(CPM)

TEO:	104380289(CPM)

BREG:

104632747(CPM)

OHA:	104326765(CPM)

ACAR:

104531860(CPM)

CPEA:

104388813(CPM)

CVF:	104288919(CPM)

RTD:	128907965(CPM)

CRID:

134510105(CPM)

AAM:	106488152(CPM)

AROW:

112970417(CPM)

NPD:	112958840(CPM)

TGT:	104574438(CPM)

DNE:	112983355(CPM)

SCAM:

104142043(CPM)

ASN:	102385520(CPM)

AMJ:	102562411(CPM)

CPOO:

109315514(CPM)

GGN:	109295716(CPM)

PSS:	102463630(CPM)

CMY:	102930730(CPM)

CCAY:

125630220(CPM)

DCC:	119845912(CPM)

CPIC:

101936032(CPM)

TST:	117877725(CPM)

CABI:

116834440(CPM)

MRV:	120395545(CPM)

ACS:	100556918(cpm)

ASAO:

132776174(CPM)

PVT:	110075131(CPM)

SUND:

121930776(CPM)

PBI:	103063247(CPM)

PMUR:

107284409(CPM)

CTIG:

120308445(CPM)

TSR:	106538065(CPM)

PGUT:

117655616(CPM)

APRI:

131201823(CPM)

PTEX:

113435767(CPM)

NSS:	113412264(CPM)

VKO:	123033308(CPM)

PMUA:

114605044(CPM)

PRAF:

128422096(CPM)

ZVI:	118090968(CPM)

HCG:	128327320(CPM)

GJA:	107105717(CPM)

STOW:

125434260(CPM)

EMC:	129336010(CPM)

XLA:	108711091(cpm.L) 108713154(cpm.S)

XTR:	496721(cpm)

NPR:	108804545(CPM)

RTEM:

120931988(CPM)

BBUF:

120980570(CPM)

BGAR:

122925810(CPM)

PWL:	138288048(CPM) 138302240

MUO:	115478175(CPM)

GSH:	117364356(CPM)

DRE:	550253(cpm)

SRX:	107710685 107728505

SANH:

107666948 107669712

SGH:	107590974(cpm)

CCAR:

109065747 109086964

CAUA:

113048227 113061649

CGIB:

127956866 127972912

PTET:

122342722(cpm)

LROH:

127163924(cpm)

OMC:	131539476(cpm)

PPRM:

120476854(cpm)

RKG:	130082682(cpm)

MAMB:

125246446(cpm)

CIDE:

127511042

CERY:

137024562(cpm)

MASI:

127435415 127436819

TROS:

130547665(cpm)

TDW:	130421133(cpm)

MANU:

129432326(cpm)

PDAB:

135750532 135760646

IPU:

108279953

IFU:	128623402(cpm)

PHYP:

113532257(cpm)

SMEO:

124401660(cpm)

TFD:	113655870(cpm)

TVC:	132859283(cpm)

CGAR:

128534028(cpm)

NGRA:

132869700(cpm)

TRN:

134325141

AMEX:

103028806(cpm)

CMAO:

118812329(cpm)

EEE:	113569671(cpm)

CHAR:

105892307(cpm)

SPIL:

134071256(cpm)

TRU:	101065920(cpm)

TFS:	130519071(cpm)

TNG:	GSTEN00034650G001

LCO:	104931508(cpm)

TBEN:

117485188(cpm)

CGOB:

115006014

PGEO:

117441017(cpm)

GACU:

117559822(cpm)

EMAC:

134879094(cpm)

ELY:	117249497(cpm)

EFO:	125882631(cpm)

SLUC:

116047906(cpm)

ECRA:

117938846(cpm)

ESP:	116673132(cpm)

PFLV:

114550286(cpm)

PPUG:

119210906(cpm)

AFB:	129112469(cpm)

CLUM:

117726362(cpm)

PSWI:

130200868(cpm)

CANA:

137791556(cpm)

CVE:	137866580(cpm)

MSAM:

119896125(cpm)

SCHU:

122871232(cpm)

CUD:	121505674(cpm)

SPUL:

138599806(cpm)

LMIX:

132956337(cpm)

ALAT:

119032365(cpm)

ASTR:

137589318(cpm)

MZE:	101469424(cpm)

ONL:	100694650(cpm)

OAU:	116312820(cpm)

OLA:	101169896(cpm)

OML:	112157427(cpm)

CSAI:

133424067(cpm)

XMA:	102218156(cpm)

XCO:	114161096(cpm)

XHE:	116736968(cpm)

PRET:

103459312(cpm)

PFOR:

103155873

PLAI:

106939951(cpm)

PMEI:

106925010

GAF:	122826414(cpm)

PPRL:

129352873(cpm)

CVG:	107090615(cpm)

CTUL:

119790611(cpm)

GMU:	124883123(cpm)

NFU:	107386863(cpm)

KMR:	108228768(cpm)

ALIM:

106532836(cpm)

NWH:

119428444

AOCE:

111586661(cpm)

EJA:	138213307(cpm)

BFRE:

138633152(cpm)

MCEP:

125000408(cpm)

CSEM:

103382529(cpm)

POV:	109646163(cpm)

SSEN:

122767290(cpm)

SSOE:

131456891(cpm)

HHIP:

117757033(cpm)

HSP:	118101940(cpm)

PPLT:

128429216(cpm)

SMAU:

118287371(cpm)

LCF:	108885735 108895863(cpm)

SDU:	111224538(cpm)

SLAL:

111665929(cpm)

XGL:	120797152(cpm)

HCQ:	109532598(cpm)

SSCV:

125985799(cpm)

SBIA:

133493761(cpm)

PEE:	133397441(cpm)

PTAO:

133471796(cpm)

BPEC:

110161911(cpm)

ENY:	140367388(cpm)

MALB:

109952968(cpm)

BSPL:

114862526(cpm)

SJO:	128353124(cpm)

SSCO:

134004746(cpm)

GMH:	115542460(cpm)

STRU:

115182046 115182933

OTW:	112240098(cpm)

OMY:	110517153 118942834

OGO:	124018752 124018753

OKI:	116360552 116372993

OKE:	127927714(cpm)

OMM:	135515556 135515566 135529152

OCLA:

139379616 139392879 139392881

SALP:

112079471

SNH:	120050144(cpm)

CCLU:

121555439(cpm)

ELS:	105017802(cpm)

OEP:	134037579(cpm)

SFM:	108936551(cpm)

PKI:	111844282 111851094(cpm) 111851214

AANG:

118219042(cpm)

AROT:

135245496(cpm)

CCOG:

133119122(cpm)

LOC:	102692210(cpm)

PSPA:

121317975 121320079

ARUT:

117396714 117414918 117419352

PSEX:

120539582(cpm)

LCM:	102355516(CPM)

CMK:	103184619 103185307(cpm)

RTP:	109928784 109934683

CPLA:

122559327 122564612

HOC:	132824844 132825758

LERI:

129706416 129711950(cpm)

PMRN:

116947440(CPM)

LRJ:

133351600

BFO:

118425712

BBEL:

109464542

SPU:	105438690 580514

LPIC:

129282994

AJJ:	139964440 139964441

APLC:

ARUN:

AAMU:

AFIL:

SKO:	100375345 100375539

PFLL:

139143737 139143738 139143739

DME:	Dmel_CG4678(CG4678)

DER:

6550015

DSE:

6617981

DSI:	Dsimw501_GD24843(Dsim_GD24843)

DYA:	Dyak_GE17613

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14727

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119666743 119671710

MDE:

SCAC:

LCQ:

LSQ:

CVJ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ019890

CPII:

CBRI:

CNS:

BCOO:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

SOY:	115879907 115888420

AGRG:

126745238

ATD:

109603743

CSET:

123312784 123312785 123316880

HAXR:

123683478

AGB:

108903476

LDC:	111502302 111510285

DVV:	114325229 114325232 126884788

NVL:

APLN:

PPYR:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207768

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

113371376 113380821 113381179

CCRN:

123294062

API:	100163058 100163764

DNX:	107168618 107169553

AGS:	114119923 114126292

RMD:	113554587 113555251

ACOO:

126838379 126838396

DVT:	126901175 126902235

BTAB:

109039932

CLEC:

106669957 106672221

HHAL:

106678144 106683340

NLU:	111044577 111064421

HVI:	124367620 124367621 124367995 124372383 124374427

MQU:	128982858 128983213

PHU:	Phum_PHUM098090

FOC:

113217736

TPAL:

117644293

ZNE:	110828034 110831202

CSEC:

111873444

PAME:

138691244 138714857

SGRE:

126341697 126344231

BROR:

134533011 134535087 134540467

IEL:	124158639 124158961

HAMR:

139686686 139691490 139692789

FCD:

110863174

DPX:	DAPPUDRAFT_39340 DAPPUDRAFT_53984

DMK:	116919902 116929845 116936652 123475797

DPZ:	124311077 124327147 124343203

AFRA:

136032051 136037125 136038644

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

EAF:	111699046 111705218 111707342

LSM:	121117865 121126808

TCF:	131877530 131888023 131889556

DSV:

RSAN:

RMP:

TUT:

DPTE:

DFR:	124490784 124500326

CSCU:

111634767 111637135

CVS:	136988037 136990454

PTEP:

107446375 107448812

ABRU:

129965638 129965782

UDV:	129232493 129234230

LPOL:

PMEO:

PCAN:

LSAX:

GAE:	121366701 121367662 121367665

HRF:

124137854

HRJ:

124283825

HASI:

137255363

CRG:	105343166 109620566

CVN:	111134694 111138443

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

127831765 127853752 127873876

MAEA:

OBI:

OSN:

EGL:

LLON:

HSY:	130613446 130613842

» show all

Reference

PMID:12457462

Authors

Tan F, Balsitis S, Black JK, Blochl A, Mao JF, Becker RP, Schacht D, Skidgel RA

Title

Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring.

Journal

Biochem J 370:567-78 (2003)
DOI:10.1042/BJ20021495

Sequence

[hsa:1368]

LinkDB

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