KEGG ORTHOLOGY: K01329

ORTHOLOGY: K01329

Entry

K01329                      KO

Symbol

CMA1

Name

chymase [EC:3.4.21.39]

Pathway

map04614

Renin-angiotensin system

map05415

Diabetic cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04614 Renin-angiotensin system
    K01329  CMA1; chymase
09160 Human Diseases
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K01329  CMA1; chymase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01329  CMA1; chymase
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.39  chymase
     K01329  CMA1; chymase
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K01329  CMA1; chymase

Genes

HSA:	1215(CMA1)

PTR:	745533(CMA1)

PPS:	100986161(CMA1)

GGO:	101131787(CMA1)

PON:	100432060(CMA1)

PPYG:

129012749(CMA1)

NLE:	100590719(CMA1)

HMH:	116485063(CMA1)

SSYN:

129489284(CMA1)

MCC:	716395(CMA1)

MCF:	102128612(CMA1)

MTHB:

126959477

MNI:	105477881(CMA1)

CSAB:

103228741(CMA1)

CATY:

105600218(CMA1)

PANU:

100999092

TGE:	112628993(CMA1)

MLEU:

105532747(CMA1)

RRO:	104662665(CMA1)

RBB:	108529495(CMA1)

TFN:	117069890(CMA1)

PTEH:

111552948(CMA1)

CANG:

105503706(CMA1)

CJC:	100388845(CMA1)

SBQ:	101040749(CMA1)

CIMI:

108297931(CMA1)

ANAN:

105727953 105727975

CSYR:

103273140(CMA1)

MMUR:

105866606 105866607

LCAT:

123650609(CMA1)

PCOQ:

105812753(CMA1)

OGA:	100952371(CMA1)

MMU:	17227(Mcpt4) 17228(Cma1)

MCAL:

110288188 110288847 110288848 110309191 110309194

MPAH:

110314663 110315169 110325079 110325080 110325354 110325355 110325569 110325712

RNO:	100360872(Mcpt1l1) 25627(Cma1)

MCOC:

116084365 116084422 116084454 116084761 116084762

ANU:	117705557 117705604 117705729 117705793 117705883 117706333

ASYL:

127690944 127691496 127691497 127691498 127691499 127691501 127691502

MUN:	110544703 110565884

CGE:	100756053 100767563

MAUA:

101842838 101843106

PROB:

127230512 127230514

PLEU:

114708716 114708743

MORG:

121435061 121435083 121435089

MFOT:

126492595 126492596 126492610

AAMP:

119800240 119800259 119800347

NGI:	103739405 103739493

HGL:	101714023 101714600(Cma1)

CPOC:

100135503(Cma1)

DORD:

105992492 105992493

DSP:	122113368 122113371

DMER:

138841942 138841996

PLOP:

125345047 125345049 125345052 125345054

NCAR:

124977281 124977311

MMMA:

107145311 107145319

ITI:	101957774 101958059

OCU:	100008644 100352190

OPI:	101529040(CMA1)

TUP:	102470931 102491108(CMA1)

GVR:	103584177 103590135 103590176

CFA:	490628(CMA1)

CLUD:

112657688(CMA1)

VVP:	112926474 112926566

VLG:	121492583 121493420

NPO:	129499396(CMA1) 129499466

AML:	100468421 100470691

UMR:	103679298 103679300

UAH:	113245992 113246021

UAR:	123795668(CMA1) 123795670

ELK:	111139042 111139669

LLV:	125104843 125105063

MPUF:

101670824(CMA1)

MNP:	131998757(CMA1)

MLK:	131836419(CMA1)

NVS:	122893097 122894514

ORO:	101371490 101371794

EJU:	114217787 114217856

ZCA:	113909271 113909731

MLX:	118003204 118003493

NSU:	110585334 110585496

LWW:	102748511 102751240(CMA1)

FCA:	101084796(CMA1)

PYU:	121031254 121031583

PCOO:

112855448 112855708

PBG:	122468961 122468962

PVIV:

125168543 125168545

LRUF:

124508202 124508873

LGF:	123583474 123583477

AJU:

106987876

PTG:	102957375 102967390(CMA1)

PPAD:

109254960(CMA1)

PUC:	125909628 125909629

PLEZ:

122221281 122221282

HHV:	120246989 120246992

BTA:	100139881 540321

BOM:

102282440

BIU:	109575276 109575291

BBUB:

112577709

BBIS:

104991006 104991060

CHX:	102171280 102174387 102183868 102188216 108635220 108638489

OAS:	101107261 101112678 114109029

BTAX:

128066767 128066773 128066820 128066859

CSUM:

138094986 138094987 138095181

ODA:	120875328 120875431

CCAD:

122419674 122419675 122454923

MREE:

136147003

MBEZ:

129550077

SSC:

100156469

CFR:	102507358(CMA1)

CBAI:

105068855(CMA1)

VPC:

102529914

BACU:

103010490(CMA1)

BMUS:

118890525(CMA1)

LVE:	103078045(CMA1)

OOR:	125963385(CMA1)

LALB:

132530710(CMA1)

GMF:	132596765(CMA1)

DLE:	111164159(CMA1)

PCAD:

102984580(CMA1)

PSIU:

PPHC:

NASI:

ECB:

EPZ:

MYB:	102252573(CMA1) 102252869

MYD:	102760823(CMA1) 102774377

MMYO:

118678514(CMA1)

MLF:	102436406 102442410

MDT:	132225779 132241198

MYUM:

139004114 139004118

PKL:	118726115(CMA1)

EFUS:

103301545(CMA1)

MNA:	107531684(CMA1)

DRO:	112300507 112300811

SHON:

AJM:

PDIC:

PHAS:

MMF:	118636167 118637047

HAI:	109393626 109393631

RFQ:

117023498

PALE:

102891376(CMA1)

PGIG:

120608539

PVP:	105309412(CMA1)

RAY:	107513520(CMA1)

MJV:	108392611 108392612

TOD:	119238079 119238080 119238973

SARA:

101538096(CMA1)

SFUM:

130041890(CMA1)

SETR:

126001040(CMA1)

LAV:

100676374

TMU:

101353027

ETF:	101640954(CMA1)

DNM:	101423444 105744604

MDO:	100025555(CMA1)

GAS:	123236004(CMA1)

SHR:	100916327 100918953 100922955 105749239 111718797

AFZ:	127550638 127551108 127551109 127551110 127551112

PCW:	110206962(CMA1)

TVP:	118829188(CMA1)

PBRV:

138168481

TACU:

119920795 119920851

SRX:	107719607 107719608 107728555

SANH:

107655230 107687720

SGH:

107599477

CCAR:

109067161 109067176 109098001

MZE:

101464713

ONL:	100691973 109204554

OAU:

PSEX:

CSET:

API:

DNX:

Reference

PMID:19720934

Authors

Sun J, Zhang J, Lindholt JS, Sukhova GK, Liu J, He A, Abrink M, Pejler G, Stevens RL, Thompson RW, Ennis TL, Gurish MF, Libby P, Shi GP

Title

Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation.

Journal

Circulation 120:973-82 (2009)
DOI:10.1161/CIRCULATIONAHA.109.849679

Sequence

[mmu:17228]

Reference

PMID:1894611

Authors

Urata H, Kinoshita A, Perez DM, Misono KS, Bumpus FM, Graham RM, Husain A

Title

Cloning of the gene and cDNA for human heart chymase.

Journal

J Biol Chem 266:17173-9 (1991)

Sequence

[hsa:1215]

LinkDB

DBGET integrated database retrieval system