KEGG   ORTHOLOGY: K01331
Entry
K01331                      KO                                     
Symbol
C1S
Name
complement component 1, s subcomponent [EC:3.4.21.42]
Pathway
map04610  Complement and coagulation cascades
map05133  Pertussis
map05150  Staphylococcus aureus infection
map05171  Coronavirus disease - COVID-19
map05322  Systemic lupus erythematosus
Disease
H00102  Classic complement pathway component defects
H02240  Ehlers-Danlos syndrome periodontal type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K01331  C1S; complement component 1, s subcomponent
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K01331  C1S; complement component 1, s subcomponent
  09171 Infectious disease: bacterial
   05133 Pertussis
    K01331  C1S; complement component 1, s subcomponent
   05150 Staphylococcus aureus infection
    K01331  C1S; complement component 1, s subcomponent
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K01331  C1S; complement component 1, s subcomponent
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01331  C1S; complement component 1, s subcomponent
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K01331  C1S; complement component 1, s subcomponent
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.42  complement subcomponent C_overbar_1s_
     K01331  C1S; complement component 1, s subcomponent
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S1: chymotrypsin family
   K01331  C1S; complement component 1, s subcomponent
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Opsonins
    K01331  C1S; complement component 1, s subcomponent
Genes
HSA: 716(C1S)
PTR: 451808(C1S)
PPS: 100991971(C1S)
GGO: 101145266(C1S)
PON: 100432027 100455685(C1S)
PPYG: 129009832 129010369(C1S)
NLE: 100599399(C1S)
HMH: 116472620(C1S)
SSYN: 129483448(C1S)
MCC: 714589(C1S)
MCF: 102137207(C1S) 135966149
MTHB: 126930476 126930486
MNI: 105484252(C1S)
CSAB: 103218499 103218857(C1S)
CATY: 105583054(C1S)
PANU: 101003889(C1S) 101009560
TGE: 112634416(C1S)
MLEU: 105541823(C1S)
RRO: 104664861 104680080(C1S)
RBB: 108542015
TFN: 117090593
PTEH: 111555895(C1S) 113222927 113222930 113222931
CANG: 105519191(C1S)
CJC: 100412274(C1S)
SBQ: 101034947(C1S)
CIMI: 108295012(C1S)
ANAN: 105731190(C1S)
CSYR: 103252208(C1S)
MMUR: 105869013(C1S)
LCAT: 123640084(C1S)
PCOQ: 105805031(C1S)
OGA: 100952754(C1S)
MMU: 317677(C1s2) 50908(C1s1)
MPAH: 110314998 110316909(C1s)
RNO: 192262(C1s)
MCOC: 116099566(C1s)
ANU: 117715251(C1s)
MUN: 110548590(C1s)
CGE: 100759777(C1s)
MAUA: 101823163(C1s)
PROB: 127239131(C1s)
PLEU: 114708804(C1s)
MORG: 121443554(C1s)
MFOT: 126514859
AAMP: 119806528(C1s)
NGI: 103727488(C1s)
HGL: 101697979(C1s)
CPOC: 100722315(C1s)
CCAN: 109682778(C1s)
DORD: 105991022(C1s)
DSP: 122101967(C1s)
NCAR: 124983519
MMMA: 107154926(C1s)
OCU: 100348898
OPI: 101519319(C1S)
TUP: 102487452 102496444(C1S)
GVR: 103595776(C1S)
CFA: 486714(C1S)
CLUD: 112675376(C1S)
VVP: 112917318(C1S)
VLG: 121480300(C1S)
NPO: 129503430(C1S)
AML: 100472516(C1S)
UMR: 103656176(C1S)
UAH: 113257945(C1S)
UAR: 123781655(C1S)
ELK: 111159747
LLV: 125106220
MPUF: 101675967(C1S)
MNP: 132019897(C1S)
MLK: 131838481(C1S)
NVS: 122891831(C1S)
ORO: 101377797(C1S)
EJU: 114222555(C1S)
ZCA: 113922111(C1S)
MLX: 118025713(C1S)
NSU: 110581007(C1S)
LWW: 102736987(C1S)
FCA: 101088676(C1S)
PYU: 121022129(C1S)
PCOO: 112867394(C1S)
PBG: 122472396(C1S)
PVIV: 125170355(C1S)
LRUF: 124502523
PTG: 102948650(C1S)
PPAD: 109276089(C1S)
PUC: 125918798
AJU: 106965335
HHV: 120220413(C1S)
BTA: 767827(C1S)
BOM: 102285301(C1S)
BIU: 109558903(C1S)
BBUB: 102392362(C1S)
BBIS: 104992162(C1S)
CHX: 102189289(C1S)
OAS: 101107688(C1S)
BTAX: 128047669(C1S)
ODA: 120858755(C1S)
CCAD: 122423699(C1S)
MBEZ: 129536835(C1S)
SSC: 397274(C1S)
CFR: 102513921(C1S)
CBAI: 105075508(C1S)
CDK: 105098188(C1S)
VPC: 102534279(C1S)
BACU: 103003533(C1S)
BMUS: 118902480(C1S)
LVE: 103085588(C1S)
OOR: 101269409(C1S)
DLE: 111176708(C1S)
PCAD: 102987496(C1S)
PSIU: 116761113(C1S)
NASI: 112391771(C1S)
ECB: 100060261(C1S)
EPZ: 103563702(C1S)
EAI: 106847309(C1S)
MYB: 102255615(C1S)
MYD: 102755154(C1S)
MMYO: 118651039(C1S)
MLF: 102433220(C1S)
PKL: 118730585(C1S)
EFUS: 103289040(C1S)
MNA: 107544114(C1S)
DRO: 112321891(C1S)
SHON: 119002258(C1S)
AJM: 119065711(C1S)
PDIC: 114513721(C1S)
PHAS: 123810667(C1S)
MMF: 118624397(C1S)
PPAM: 129085046(C1S)
HAI: 109373658(C1S)
RFQ: 117029113(C1S)
PALE: 102897110(C1S)
PGIG: 120611678(C1S)
PVP: 105295936(C1S)
RAY: 107519836(C1S)
MJV: 108384826(C1S)
TOD: 119247759(C1S)
SARA: 101547063(C1S)
SETR: 126006663(C1S)
LAV: 100676140(C1S)
TMU: 101344169
ETF: 101663099(C1S)
DNM: 101436067(C1S)
MDO: 100016766(C1S)
GAS: 123249051(C1S)
SHR: 100917190(C1S)
AFZ: 127564067
PCW: 110213806(C1S)
TVP: 118851800(C1S)
OAA: 100085003(C1S)
GGA: 418294(C1S)
PCOC: 116239944(C1S)
MGP: 100549400(C1S)
CJO: 107318599(C1S)
TPAI: 128089839(C1S)
LMUT: 125685221(C1S)
NMEL: 110398269(C1S)
APLA: 101791779(C1S)
ACYG: 106047861(C1S)
CATA: 118247559(C1S)
AFUL: 116496502(C1S)
TGU: 100222051(C1S)
LSR: 110480852(C1S)
SCAN: 103812468(C1S)
PMOA: 120506494(C1S)
OTC: 121339352(C1S)
PRUF: 121351614(C1S)
GFR: 102043120(C1S)
FAB: 101809291(C1S)
OMA: 130259810(C1S)
PHI: 102112114(C1S)
PMAJ: 107207087(C1S)
CCAE: 111938155(C1S)
CCW: 104687135(C1S)
CBRC: 103613962(C1S)
ETL: 114058181(C1S)
ZAB: 102071401(C1S)
ZLE: 135453107(C1S)
ACHL: 103799611(C1S)
SVG: 106857861(C1S)
MMEA: 130574806(C1S)
HRT: 120748561(C1S)
FPG: 101915039(C1S)
FCH: 102049047(C1S)
CLV: 102093208(C1S)
EGZ: 104126544(C1S)
NNI: 104009512(C1S)
PCRI: 104026681(C1S)
PLET: 104616159(C1S)
EHS: 104513634(C1S)
PCAO: 104045746(C1S)
ACUN: 113479841(C1S)
TALA: 104362087(C1S)
PADL: 103920878(C1S)
AFOR: 103905459(C1S)
ACHC: 115343835(C1S)
HALD: 104312695(C1S)
HLE: 104831782(C1S)
AGEN: 126049063
GCL: 127029339
CCRI: 104157021(C1S)
CSTI: 104558311(C1S)
CMAC: 104475392(C1S)
MUI: 104540487(C1S)
BREG: 104631673(C1S)
FGA: 104078995(C1S)
GSTE: 104257359(C1S)
LDI: 104346353(C1S)
MNB: 103770372(C1S)
OHA: 104327130(C1S)
NNT: 104401342(C1S)
SHAB: 115601495(C1S)
PGUU: 104463167(C1S)
ACAR: 104520043(C1S)
CPEA: 104389443(C1S)
AVIT: 104279030(C1S)
CVF: 104292922(C1S)
RTD: 128902151(C1S)
CUCA: 104064359(C1S)
TEO: 104374572(C1S)
BRHI: 104495690(C1S)
AAM: 106497286(C1S)
AROW: 112973003(C1S)
NPD: 112945576(C1S)
TGT: 104565657(C1S)
DNE: 112991082(C1S)
SCAM: 104150723(C1S)
ASN: 102373441(C1S)
AMJ: 102572422(C1S)
CPOO: 109319374(C1S)
GGN: 109304790(C1S)
PSS: 102460272
CMY: 102946599(C1S)
CCAY: 125622817(C1S)
DCC: 119861421(C1S)
CPIC: 101944626(C1S)
TST: 117885631(C1S) 117886664
CABI: 116821039(C1S)
MRV: 120370719 120395337(C1S)
ACS: 100558615(c1s) 100560720
ASAO: 132767516
PVT: 110084650(C1S)
SUND: 121922922(C1S)
PBI: 103065043(C1S)
PMUR: 107285780(C1S)
CTIG: 120306115(C1S)
TSR: 106553465(C1S)
PGUT: 117661832(C1S)
APRI: 131193687(C1S)
PTEX: 113444439(C1S)
NSS: 113417163(C1S)
VKO: 123033203(C1S)
PMUA: 114587883(C1S)
PRAF: 128404589(C1S)
ZVI: 118097884(C1S)
HCG: 128342815(C1S)
GJA: 107120852 107123505
STOW: 125437225(C1S)
EMC: 129345422(C1S)
XLA: 733422(c1s.L)
XTR: 613055(c1s)
NPR: 108784394(C1S)
RTEM: 120946626(C1S)
BBUF: 121003772(C1S)
BGAR: 122941008(C1S)
MUO: 115457679(C1S)
GSH: 117350026(C1S)
SRX: 107714593 107724792
CAUA: 113081686 113099592
LROH: 127178407
OMC: 131522168
RKG: 130090827
TROS: 130557521
TDW: 130433448
MANU: 129448199
TRN: 134310857
AMEX: 103027368
EEE: 113574793
TRU: 101072918 115250374
TFS: 130532935(c1s.2)
TNG: GSTEN00015325G001
NCC: 104941464
PGEO: 117461091
EMAC: 134861245
AFB: 129109514(c1s.2)
PSWI: 130213497(c1s.2)
MSAM: 119896349 119897430 119897431
MZE: 105940904
ONL: 100711586
OAU: 120442843(c1s.2)
CSAI: 133434870(c1s.2)
CVG: 107082194
ALIM: 106529166
LCF: 108880738(c1s.2)
BPEC: 110163037
OMY: 110503575
OKE: 118367891
SALP: 112074549
ELS: 105009774
PKI: 111835376
LOC: 102687802
PSPA: 121326273
ARUT: 117425904
PSEX: 120535739
LCM: 102354579(C1S)
CMK: 103189668 103190346
RTP: 109914345
CPLA: 122542919 122542923
HOC: 132836653
LERI: 129716458 129716463
 » show all
Reference
PMID:3500856
  Authors
Mackinnon CM, Carter PE, Smyth SJ, Dunbar B, Fothergill JE
  Title
Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence.
  Journal
Eur J Biochem 169:547-53 (1987)
DOI:10.1111/j.1432-1033.1987.tb13644.x
  Sequence
[hsa:716]
Reference
PMID:14748705
  Authors
Sim RB, Tsiftsoglou SA
  Title
Proteases of the complement system.
  Journal
Biochem Soc Trans 32:21-7 (2004)
DOI:10.1042/bst0320021
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