Entry
Symbol
neuB, nnaB
Name
N-acetylneuraminate synthase [EC:
2.5.1.56 ]
Pathway
map00541 Biosynthesis of various nucleotide sugars
map01250 Biosynthesis of nucleotide sugars
Module
M00922 CMP-Neu5Ac biosynthesis, bacteria, UDP-GlcNAc => CMP-Neu5Ac
Reaction
R01804 phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
R04435 phosphoenolpyruvate:N-acetyl-D-mannosamine-6-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09107 Glycan biosynthesis and metabolism
00541 Biosynthesis of various nucleotide sugars
K01654 neuB, nnaB; N-acetylneuraminate synthase
Enzymes [BR:ko01000 ]
2. Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.56 N-acetylneuraminate synthase
K01654 neuB, nnaB; N-acetylneuraminate synthase
BRITE hierarchy
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Genes
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Taxonomy UniProt
Reference
Authors
Sundaram AK, Pitts L, Muhammad K, Wu J, Betenbaugh M, Woodard RW, Vann WF
Title
Characterization of N-acetylneuraminic acid synthase isoenzyme 1 from Campylobacter jejuni.
Journal
Reference
Authors
Suryanti V, Nelson A, Berry A
Title
Cloning, over-expression, purification, and characterisation of N-acetylneuraminate synthase from Streptococcus agalactiae.
Journal
Reference
Authors
Lewis AL, Robinson LS, Agarwal K, Lewis WG
Title
Discovery and characterization of de novo sialic acid biosynthesis in the phylum Fusobacterium.
Journal
Sequence
Reference
Authors
Feng L, Senchenkova SN, Tao J, Shashkov AS, Liu B, Shevelev SD, Reeves PR, Xu J, Knirel YA, Wang L
Title
Structural and genetic characterization of enterohemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay.
Journal
Sequence
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