KEGG ORTHOLOGY: K02271

ORTHOLOGY: K02271

Entry

K02271                      KO

Symbol

COX7B

Name

cytochrome c oxidase subunit 7b

Pathway

map00190

Oxidative phosphorylation

map01100

Metabolic pathways

map04260

Cardiac muscle contraction

map04714

Thermogenesis

map04932

Non-alcoholic fatty liver disease

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05208

Chemical carcinogenesis - reactive oxygen species

map05415

Diabetic cardiomyopathy

Module

M00154

Cytochrome c oxidase

Disease

H01904

Microphthalmia with linear skin defects syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K02271  COX7B; cytochrome c oxidase subunit 7b
09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K02271  COX7B; cytochrome c oxidase subunit 7b
  09159 Environmental adaptation
   04714 Thermogenesis
    K02271  COX7B; cytochrome c oxidase subunit 7b
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K02271  COX7B; cytochrome c oxidase subunit 7b
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02271  COX7B; cytochrome c oxidase subunit 7b
   05012 Parkinson disease
    K02271  COX7B; cytochrome c oxidase subunit 7b
   05014 Amyotrophic lateral sclerosis
    K02271  COX7B; cytochrome c oxidase subunit 7b
   05016 Huntington disease
    K02271  COX7B; cytochrome c oxidase subunit 7b
   05020 Prion disease
    K02271  COX7B; cytochrome c oxidase subunit 7b
   05022 Pathways of neurodegeneration - multiple diseases
    K02271  COX7B; cytochrome c oxidase subunit 7b
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K02271  COX7B; cytochrome c oxidase subunit 7b
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K02271  COX7B; cytochrome c oxidase subunit 7b

Other DBs

TC:

3.D.4.11

Genes

HSA:	1349(COX7B) 170712(COX7B2)

PTR:	100615314(COX7B2) 465727(COX7B)

PPS:	100982199 100986707 117976096 117977251

GGO:	101127312 101133386 101147253

PON:	100172849(COX7B) 100451432 112128708

PPYG:

129012698 129022126 129023249 129025132 129035601

NLE:	100591930 100602515 115837591

HMH:	116456710 116458524 116460740 116811106 116812505 116812582

SSYN:

129463206 129464467 129467246 129468796 129474679 129476008 129490577

MCC:	100428437(COX7B2) 706099(COX7B)

MCF:	102123270(COX7B2) 102124180(COX7B)

MTHB:

126942189 126946324 126955253

MNI:	105464285 105471304 105487680

CSAB:

103232235(COX7B) 103246147(COX7B2)

CATY:

105596112 105596144

PANU:

101013709 103884346 116269782

TGE:	112614586 112615961 112625015

MLEU:

105530782 105538264

RRO:	104669550 104671254 104680071 115900678

RBB:	108519915 108530029 108535638

TFN:	117076746 117078522 117085655

PTEH:

111536059 111548777 111550927

CANG:

105501404 105512711 105515614

CJC:	100390732 100414729(COX7B2) 118153966

SBQ:	101048999 101052499

CIMI:

108292295 108297237 108312415

ANAN:

105709223 105719611 110567178

CSYR:

103267420 103274382

MMUR:

105859339 109729584 109730255

LCAT:

123621919 123624263

ERUF:

138378274(COX7B)

PCOQ:

105806701 105826189

OGA:	100951826 100953844 100958320 100965534

MMU:	66142(Cox7b) 78174(Cox7b2)

MCAL:

110286765 110295372

MPAH:

110313979 110330226

RNO:	100361960(Cox7b2) 303393(Cox7b)

MCOC:

116071167 116087988

ANU:	117694048(Cox7b) 117712474(Cox7b2)

ASYL:

127675383 127696217

MUN:	110541746 110541909 110543482 110565114 132647959

CGE:	100764866 100772782 113834565

MAUA:

101829663 101834758

PROB:

127217663

PLEU:

114689841 114690723 114694791 114704883

PMAV:

102903361(Cox7b)

MORG:

121442733 121444814 121451002 121457965 121460628 121465057

MFOT:

126493461 126506197

AAMP:

119804752 119807117 119821824 119824561

CNL:	130867935 130870320 130870325 130872717

NGI:	103737829 103737882

HGL:	101715696 101719726 101722775 106010133

CPOC:

100719234 100723369

CCAN:

109680062 109686755

DORD:

105980179 105995218

DSP:	122097646 122106921

PLOP:

125344094 125357365 125364518

NCAR:

124972073 124978951 124994104

SVUL:

306644141(ACX6B4_006573) 306651425(COX7B) 306661551(ACX6B4_023983)

MMMA:

107138951 107159289

ITI:	101957551 101967130 101968917 101969650 120889201

OCU:	100339628 100342996 100348984 100353320 100356786 100357660

OPI:	101517779 101519995 101529981 101533664 101535821

OCZ:	121144713 121146609 121163503 121169356

TUP:	102475894 102498058

GVR:

103609950

CFA:	100683076 100684842 100684983 100686510 100687434(COX7B2) 102152785

CLUD:

112643473 112650945 112652117 112664558 112671885 112678421 118352292

VVP:	112909193 112933364

VLG:	121474273 121477994 121478414 121482288 121497750

NPO:	129503871 129510926 129517518 129517615 129518990

AML:	100466075 100475526

UMR:	103656462 103672701 103675819

UAH:	113242144 113254915 113262375

UAR:	123794870 123799314 123803988

ELK:	111146524 111149314 111149315 111156868 111160926

LLV:	125078870 125091810 125094364 125097679

MPUF:

101672021 101691909

MNP:	132001951 132007782 132015566

MLK:	131809285 131821722 131824398

NVS:	122889784 122897159 122900125

ORO:	101370574 101371666 101377905 101383837

EJU:	114200424 114207401 114210260

ZCA:	113914243 113915131 113919563 113925088 113931503 118356894

MLX:	118010248 118015405 118026049

MANO:

123847640 123847934 123858582

NSU:	110578761 110590872

LWW:	102738272 102748999

FCA:	101085531 101098629(COX7B2)

PYU:	121025331 121036249

PCOO:

112858534 112870951

PBG:	122477015 122478926

PVIV:

125157951 125164161

LRUF:

124509547 124519930

LGF:	123594670 123596037

AJU:	106986098 106986669

PTG:	102951800 102970291

PPAD:

109245506 109258957

PUC:	125922726 125931786

PLEZ:

122218268

HHV:	120220950 120224488 120234430

CCRU:

144226341(COX7B2) 144238885(COX7B)

BTA:	100300550(COX7B) 767916(COX7B2)

BOM:	102265796(COX7B2) 102277731(COX7B)

BIU:	109560438 109561950

BJV:	133233343 133242018 133243132 133249510

BBUB:

102395589 102396784 102401698 102406515 102411142 102413395

BKE:	129633235 129637024 129639167 129646618 129657828 129658785

BBIS:

104992608 104995784 105002319

CHX:	102184512 102186286

OAS:	101108109 101111228 101116886 101121518

OCAN:

138432744 138442902(COX7B2) 138931098(COX7B)

BTAX:

128070083

CSUM:

138071195(COX7B) 138082412(COX7B2)

ODA:	120862086 120863879 120879600 120881948

CCAD:

122422191 122427709 122435324 122444030

MREE:

136148074(COX7B2) 136154113(COX7B)

OVR:	110130144(COX7B) 110135220(COX7B2) 110135908

MBEZ:

129534867

SSC:	100516480 100517408

CFR:	102506447 102509421

CBAI:

105065507 105074919

CDK:	105095562 105096479

VPC:	102527993 102540595

BACU:

103011737 103017687 103019246

BMUS:

118889202 118889263 118891901 118896060

LVE:	103071977 103079623 103082153

OOR:	101272241 101275626 101278311

LALB:

132513365 132513606 132519360

GMF:	115848723(COX7B) 115865603(COX7B2)

DDP:	132418432(COX7B) 132425997(COX7B2)

SCOO:

307180443(COX7B) 307180752(ACYUVP_006025)

DLE:	111171524 111178277

PCAD:

102977966 102986020

PSIU:

116747406 116747960 116754418

PPHC:

136123826(COX7B2) 136142572(COX7B)

NASI:

112390686 112390687 112400382

HAMP:

307051942(LOC307051942) 307055059(COX7B2) 307069007(COX7B)

ECB:	100629332(COX7B2) 100630758

EPZ:	103541818(COX7B) 103551834(COX7B2)

EAI:	106841238 106846922

MYB:	102248066 102249757 102256817 102257114

MYD:	102769655 102770550

MMYO:

118651610 118654460

MLF:	102419247 102433141

MDT:	132223274 132227476

MYUM:

139002152 139007286(COX7B2)

PKL:	118707200 118717822 118719979

EFUS:

103284939 103291503 103300104 103303650

POTS:

308239678(COX7B)

MNA:	107532759 107533317

DRO:	112316645 112317931

SHON:

118978653 118980993

AJM:	119039407 119039459 119046078

PDIC:

114493439 114504937 118501211

PHAS:

123815903 123817363 123818042 123824316

MMF:	118615384 118618411 118627002 118635961 118640230

PPAM:

129065349 129074346 129077717 129084869 129086072

HAI:	109385653 109395055

RFQ:	117017505 117022452 117025637 117034361

PALE:

102883692 102883704 102888814

PGIG:

120588028 120588365 120591688

PVP:	105293916 105294928 105308883

RAY:

107519004

MJV:	108384221(COX7B2) 108396709(COX7B)

TOD:	119232300 119242999 119246658 119261139

SARA:

101551046

SFUM:

130032641

SETR:

125999312 126020094

LAV:	100658215 100666763

TMU:	101347679 101353725 101355622 111821449

ETF:	101650318 101655666

DNM:	101423721 101432149 111759679 111764174

MDO:

100012618

GAS:	123234978 123253359

SHR:

100932664

AFZ:

127542331

PCW:

110193034

TVP:	118832739 118833008 118837374 118839231 118844231 118858272

PBRV:

138141705(COX7B)

MLAO:

141490189 141497844(COX7B)

OAA:

100073487

TACU:

119929859

GGA:	771947(COX7B)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

AACU:

137863565(COX7B)

OJA:

118167065

BCLA:

308448877(COX7B)

ACYG:

106038569(COX7B)

CATA:

118245534

AFUL:

116494355

TGU:	100219756(COX7B)

LSR:	110467902(COX7B)

VMC:

128814266

VCHA:

128795395

AIB:	137482691(COX7B)

SCAN:

PMOA:

OTC:

PRUF:

MATE:

MAEN:

136562578(COX7B)

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

138110581(COX7B)

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136370489(COX7B)

CFAI:

136300322(COX7B)

CCIC:

NNT:

SHAB:

POCC:

FPG:

FCH:

FRS:

CCRI:

ACUN:

ANOC:

141964542(COX7B)

SURA:

141949387(COX7B)

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

BBUT:

142043244(COX7B)

GCL:

CSTI:

LDI:

MNB:

DPUB:

PPUS:

IIN:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PARX:

142062990(COX7B)

PADL:

103920169

AFOR:

103896595

FGA:

104069070

CBOR:

142087812(COX7B)

GSTE:

104261961

CBOY:

140658317(COX7B)

MAME:

142414968(COX7B)

CLV:

CNIC:

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

PCUR:

138726034(COX7B)

TEO:

BREG:

GAME:

OHA:

ACAR:

CEUR:

306724808(COX7B)

CPEA:

CVF:

RTD:

CRID:

LMIC:

141748407(COX7B)

NARQ:

141464866(COX7B)

AAM:

AROW:

NPD:

DNE:

ASN:

AMJ:	102572384(COX7B)

CPOO:

109313699

GGN:

109300719

PSS:	102452704(COX7B)

CIZ:	142020064(COX7B)

CMY:

102946319

CCAY:

125642916

LKP:	140917735(COX7B)

NDS:	141993609(COX7B)

DCC:

119861334

CPIC:

101945370

TST:

117883341

CABI:

116817154(COX7B)

MRV:

120371339

EMQ:	137153159(COX7B)

ASAO:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

139322581(COX7B)

APRI:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108700072(cox7b.S) 447278(cox7b.L)

XTR:	779702(cox7b)

NPR:

108803510

RTEM:

120921904

ACAT:

141108860(COX7B)

PADS:

140342952(COX7B)

BBUF:

120977735

BGAR:

122946647

DTC:	141059961(COX7B)

PCOB:

134948894

PWL:	138261757(COX7B)

MUO:	115474214(COX7B)

GSH:	117349441 117351978 117361645(COX7B)

DRE:	563476(cox7b)

SRX:	107713147 107726769

SANH:

107675192 107697350

SGH:	107582003 107598778

CCAR:

CAUA:

CGIB:

PTET:

LROH:

GRF:	141285408(cox7b)

OMC:

PPRM:

RKG:

MAMB:

CERY:

137012994(cox7b)

MASI:

127428897 127430549

TROS:

130570490

TDW:

130408118

MANU:

129424168(cox7b)

PDAB:

135776921(cox7b)

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:	101066275(cox7b)

TFS:

130537018

TNG:	GSTEN00014630G001

NCC:

104965587

TBEN:

117490334

CGOB:

115018636

PGEO:

117458753(cox7b)

GACU:

117554589

EMAC:

134871515

ELY:	117265289(cox7b)

EFO:

125898902

PLEP:

121952815

SLUC:

116055995

SVIT:

144528111(cox7b)

ECRA:

ESP:

PFLV:

PFLT:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CVE:	137876212(cox7b)

AMIR:

142960561(cox7b)

MSAM:

119896019

SCHU:

122887943

EARM:

139295551(cox7b)

CUD:

121518941

SPUL:

138602342(cox7b)

LMIX:

132988857

HTC:	141791914(cox7b)

ALAT:

119031206

ASTR:

137606481(cox7b)

PKLU:

139213141(cox7b)

LCO:

104918951

MZE:	101478334(cox7b)

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

103460001(cox7b)

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

LTU:	140280093(cox7b)

MCEP:

125021154

AOCE:

111563009

EJA:	138196066(cox7b)

BFRE:

138627394(cox7b)

LCF:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125982210(cox7b)

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140360691(cox7b)

MALB:

BSPL:

SJO:

SSCO:

TTY:	137195920(cox7b)

GMH:

115547008

SASA:

106568019(COX7B) 106603475(CX7B2)

STRU:

115148809(cox7b) 115154278

OTW:

112257912

OMY:

110537530

OGO:	123994618 123998740

ONE:	115105494 115136485

OKI:

109892782

OKE:	118391117 127933114

OMM:

135548648

OCLA:

139419494 139423147

SALP:

111951107 111980259

SNH:	120030632 120056509

SFON:

CCLU:

OEP:

SFM:

PKI:

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

CPUN:

140495981(cox7b)

HOC:

132820147

SCAU:

119952098(cox7b) 119974694

LERI:

129702027

HAKA:

140734260(cox7b)

PMRN:

116958322

» show all

Reference

PMID:23122588

Authors

Indrieri A, van Rahden VA, Tiranti V, Morleo M, Iaconis D, Tammaro R, D'Amato I, Conte I, Maystadt I, Demuth S, Zvulunov A, Kutsche K, Zeviani M, Franco B

Title

Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease.

Journal

Am J Hum Genet 91:942-9 (2012)
DOI:10.1016/j.ajhg.2012.09.016

Reference

PMID:8382530

Authors

Sadlock JE, Lightowlers RN, Capaldi RA, Schon EA

Title

Isolation of a cDNA specifying subunit VIIb of human cytochrome c oxidase.

Journal

Biochim Biophys Acta 1172:223-5 (1993)
DOI:10.1016/0167-4781(93)90301-S

Sequence

[hsa:1349]

LinkDB

DBGET integrated database retrieval system