KEGG ORTHOLOGY: K02740

ORTHOLOGY: K02740

Entry

K02740                      KO

Symbol

PSMB8, LMP7

Name

20S proteasome subunit beta 8 [EC:3.4.25.1]

Pathway

map03050

Proteasome

Disease

H01741

Autoinflammation lipodystrophy and dermatosis syndrome

H02532

Proteasome-associated autoinflammatory syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
  09182 Protein families: genetic information processing
   03051 Proteasome
    K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
Peptidases and inhibitors [BR:ko01002]
Threonine peptidases
  Family T1: proteasome family
   K02740  PSMB8, LMP7; 20S proteasome subunit beta 8
Proteasome [BR:ko03051]
Eukaryotic proteasome
  Core particles (20S proteasome)
   beta type subunits
    K02740  PSMB8, LMP7; 20S proteasome subunit beta 8

Genes

HSA:	5696(PSMB8)

PTR:	746418(PSMB8)

PPS:	100969919(PSMB8)

GGO:	101136133(PSMB8)

PON:	100445244(PSMB8)

PPYG:

129038175(PSMB8)

NLE:	100604916(PSMB8)

HMH:	116460422(PSMB8)

SSYN:

129472996(PSMB8)

MCC:	717766(PSMB8)

MCF:	102141301(PSMB8)

MTHB:

126952704

MNI:	105474424(PSMB8)

CSAB:

103221690(PSMB8)

PANU:

101015801(PSMB8)

TGE:	112623509(PSMB8)

MLEU:

105531117(PSMB8)

RRO:	104666627(PSMB8)

RBB:	108512978(PSMB8)

TFN:	117087013(PSMB8)

PTEH:

111528123(PSMB8)

CANG:

105513819(PSMB8)

CJC:	100406682(PSMB8)

SBQ:

101050853

CIMI:

108300078(PSMB8)

ANAN:

105704654(PSMB8)

CSYR:

103271933(PSMB8)

MMUR:

105886024(PSMB8)

LCAT:

123631803(PSMB8)

ERUF:

138395335(PSMB8)

PCOQ:

105824380(PSMB8)

OGA:	100958703(PSMB8)

MMU:	16913(Psmb8)

MCAL:

110312690(Psmb8)

MPAH:

110335701(Psmb8)

RNO:	24968(Psmb8)

MCOC:

116074433(Psmb8)

ANU:	117724449(Psmb8)

ASYL:

127669416(Psmb8)

MUN:	110543263(Psmb8)

CGE:	100751746(Psmb8)

MAUA:

101835386(Psmb8)

PROB:

127224280(Psmb8)

PLEU:

114686352(Psmb8)

PMAV:

102912863(Psmb8)

MORG:

121435282(Psmb8)

MFOT:

126499448

AAMP:

119823267(Psmb8)

CNL:	130890623(Psmb8)

NGI:	103748237(Psmb8)

HGL:	101702300(Psmb8)

CPOC:

100717290(Psmb8)

CCAN:

109686708(Psmb8)

DORD:

105999857(Psmb8)

DSP:	122111483(Psmb8)

DMER:

138828188(Psmb8)

PLOP:

125352722(Psmb8)

NCAR:

124988937

SVUL:

306666041(PSMB8)

MMMA:

107143778(Psmb8)

ITI:	101960734(Psmb8)

OCU:

100351918

OPI:	101535709(PSMB8)

OCZ:	121161970(PSMB8)

TUP:	102484029(PSMB8)

GVR:	103608008(PSMB8)

CFA:	474865(PSMB8)

CLUD:

112641382(PSMB8)

VVP:	112913863(PSMB8)

VLG:	121494759(PSMB8)

NPO:	129512880(PSMB8)

AML:	100477784(PSMB8)

UMR:	103665514(PSMB8)

UAH:	113243782(PSMB8)

UAR:	123790944(PSMB8)

ELK:

111152369

LLV:

125103274

MPUF:

101691295(PSMB8)

MNP:	132017856(PSMB8)

MLK:	131834273(PSMB8)

NVS:	122899862(PSMB8)

ORO:	101371019(PSMB8)

EJU:	114222138(PSMB8)

ZCA:	113927770(PSMB8)

MLX:	118001397(PSMB8)

NSU:	110575562(PSMB8)

LWW:	102748767(PSMB8)

FCA:	111556170(PSMB8)

PYU:	121029259(PSMB8)

PCOO:

112862919(PSMB8)

PBG:	122489375(PSMB8)

PVIV:

125165408(PSMB8)

LRUF:

124528923

LGF:	123608214(PSMB8)

AJU:

106976129

PTG:	102958580(PSMB8)

PPAD:

109271412(PSMB8)

PUC:

125938392

PLEZ:

122219753(PSMB8)

HHV:	120238161(PSMB8)

CCRU:

144223993(PSMB8)

BTA:	282013(PSMB8)

BOM:	102283566(PSMB8)

BIU:	109577141(PSMB8)

BJV:	133236071(PSMB8)

BBUB:

102391390(PSMB8)

BKE:	129646067(PSMB8)

BBIS:

104994882(PSMB8)

CHX:	102180902(PSMB8)

OAS:	100174905(PSMB8)

OCAN:

138425794(PSMB8)

BTAX:

128056296(PSMB8)

CSUM:

138069453(PSMB8)

ODA:	120869863(PSMB8)

CCAD:

122429561(PSMB8)

MREE:

136151352(PSMB8)

OVR:	110146958(PSMB8)

MBEZ:

129543430(PSMB8)

SSC:	396975(PSMB8)

CFR:	102519631(PSMB8)

CBAI:

105064242(PSMB8)

CDK:	105101405(PSMB8)

VPC:	102535478(PSMB8)

BACU:

103011762(PSMB8)

BMUS:

118903735(PSMB8)

LVE:	103084339(PSMB8)

OOR:	101290117(PSMB8)

LALB:

132527217(PSMB8)

GMF:	115844184(PSMB8)

DDP:	132431582(PSMB8)

SCOO:

307192244(PSMB8)

DLE:	111178661(PSMB8)

PCAD:

102995453(PSMB8)

PSIU:

116762909(PSMB8)

PPHC:

136129182(PSMB8)

NASI:

112414081(PSMB8)

HAMP:

307058779(PSMB8)

ECB:	100052481(PSMB8)

EPZ:	103544695(PSMB8)

EAI:	106834614(PSMB8)

MYB:	102245229(PSMB8)

MYD:	102761800(PSMB8)

MMYO:

118679635(PSMB8)

MLF:	102422161(PSMB8)

MDT:	132237494(PSMB8)

MYUM:

139012638(PSMB8)

PKL:	118705665(PSMB8)

EFUS:

103305025(PSMB8)

POTS:

308247635(PSMB8)

MNA:	107542675(PSMB8)

DRO:	112302285(PSMB8)

SHON:

118991467(PSMB8)

AJM:	119049934(PSMB8)

PDIC:

114494488(PSMB8)

PHAS:

123816531(PSMB8)

MMF:	118621115(PSMB8)

PPAM:

129067355(PSMB8)

HAI:	109378147(PSMB8)

RFQ:	117015676(PSMB8)

PALE:

102893806(PSMB8)

PGIG:

120597656(PSMB8)

PVP:

105300968

RAY:	107511997(PSMB8)

MJV:	108389188 118969946(PSMB8)

TOD:	119253281(PSMB8)

SARA:

101558371(PSMB8)

SFUM:

130040407(PSMB8)

SETR:

125995696(PSMB8)

LAV:	100664123(PSMB8)

TMU:

101342060

ETF:	101639342(PSMB8)

DNM:	101422881(PSMB8)

MDO:	100026706(PSMB8)

GAS:	123245213(PSMB8)

SHR:	116423204(PSMB8)

AFZ:

127561631

PCW:	110199437(PSMB8)

TVP:

118856804

PBRV:

138150042(PSMB8)

MLAO:

141523421 141523426

OAA:	100529058(PSMB8)

TACU:

119922258(PSMB8)

ASN:

106722823

AMJ:	109286085(PSMB8)

CIZ:	142025145(PSMB8)

CMY:	119567536(PSMB8)

CCAY:

125621143(PSMB8)

NDS:	141997999(PSMB8)

DCC:	119842597(PSMB8)

CPIC:

101952518(PSMB8)

CABI:

116826954

MRV:	120393309(PSMB8) 120394815

EMQ:	137156634 137157438

ACS:	100559169(psmb8)

ASAO:

132765337(PSMB8)

PVT:

110071035

SUND:

121923036(PSMB8) 121923190

PBI:	103057075(PSMB8)

PMUR:

107298997

CTIG:

120317822(PSMB8)

PGUT:

117670034(PSMB8)

PCAE:

139311812(PSMB8)

APRI:

131190458

PTEX:

113451020(PSMB8)

NSS:	113425987(PSMB8)

VKO:	123023276(PSMB8)

PMUA:

114591070 114592358

PRAF:

128409469(PSMB8)

ZVI:	118081365(PSMB8)

HCG:	128347546(PSMB8)

STOW:

125428909(PSMB8)

EMC:	129326944(PSMB8)

XLA:	399439(psmb8.L)

XTR:	100485711 445258(psmb8)

NPR:	108788367(PSMB8)

RTEM:

120914286(PSMB8)

ACAT:

141107500(PSMB8)

PADS:

140343517(PSMB8)

BBUF:

120977451(PSMB8)

BGAR:

122946484(PSMB8)

DTC:	141051727(PSMB8)

HSQ:	130290978(PSMB8)

PCOB:

134949547(PSMB8)

PWL:	138301435(PSMB8)

MUO:	115459446 115464931(PSMB8)

GSH:	117349881(PSMB8)

DRE:	30666(psmb8a)

DAES:

130246848(psmb8a)

SRX:	107705860 107712559 107722803(psmb8)

SANH:

107679352 107694197 107694758

SGH:	107549856 107554342 107574275

CCAR:

109102325 109111463 122140870

CAUA:

113062601 113102786 113119658

CGIB:

127935751 127979739

PTET:

122335238(psmb8a)

LROH:

127160980 127162473(psmb8a)

GRF:	141290062(psmb8a)

OMC:	131525171 131525721(psmb8a)

RKG:	130102314 130102352

SCEP:

307162893(psmb8a)

MAMB:

125266074 125274606(psmb8a) 125275811

CIDE:

127500843 127501474

CERY:

137037731(psmb8a)

MASI:

127421102 127421103

TROS:

130566602

TDW:	130415195 130415878

MANU:

129455657(psmb8a)

PDAB:

135776196(psmb8a)

IPU:	108258500 108258501

IFU:	128601941 128602069(psmb8a)

PHYP:

113537507 113537508

SMEO:

124378082(psmb8a)

TFD:	113648940(psmb8a)

TVC:	132839238(psmb8a)

CGAR:

128506563(psmb8a)

NGRA:

132866247 132866248

TRN:	134305380(psmb8a)

AMEX:

103025308(psmb8a)

CMAO:

118805917(psmb8a)

EEE:

113581270

CHAR:

105888923(psmb8a)

SPIL:

134072875(psmb8a)

ASAD:

121695509

TRU:	101077532(psmb8a) 115251835

TNG:	GSTEN00033724G001

NCC:

104959103

TBEN:

117478162(psmb8a)

CGOB:

115016197(psmb8)

PGEO:

117455352(psmb8a)

GACU:

117534679(psmb8a)

EMAC:

134875354(psmb8a)

ELY:	117263584 117263778(psmb8a)

EFO:	125904724(psmb8a)

PLEP:

121958140(psmb8a) 121966615

SLUC:

116047054(psmb8a)

SVIT:

144528429 144529199

ECRA:

117956859(psmb8a)

ESP:	116701195(psmb8)

PFLV:

114568377(psmb8)

PFLT:

120571267(psmb8a)

GAT:	120825989 120825990 120825991 120825992 120825993 120825994 120826001 120826767(psmb8a) 120826772 120826884

PPUG:

119218713 119218720 119218857 134107056 134107057 134107066 134107067 134107085 134107136 134107137 134107145 134107151 134107168(psmb8a)

AFB:	129097329(psmb8a)

CLUM:

117738848(psmb8a)

CANA:

137785199(psmb8a)

TBU:	306749036(psmb8a)

CVE:	137872557(psmb8a)

AMIR:

142965385(psmb8a)

MSAM:

119884281(psmb8a)

SCHU:

122864411(psmb8a)

EARM:

139298958(psmb8a)

CUD:	121523162(psmb8a)

SPUL:

138608369(psmb8a)

LMIX:

132991105(psmb8a)

HTC:	141802812(psmb8a)

ALAT:

119014628(psmb8a)

ASTR:

137606994(psmb8a)

PKLU:

139215920(psmb8a)

LCO:	104933383(psmb8)

MZE:	101480087(psmb8a)

ONL:	100697999(psmb8)

OAU:	116317727(psmb8a) 116324042 120435545

OLA:	100049532(psmb8)

OML:	112137399(psmb8a) 112140153

CSAI:

133460681(psmb8a)

XMA:

102219510

XCO:

114156482

XHE:

116730567

PRET:

103472925(psmb8a)

PFOR:

103146407(psmb8)

PMEI:

106908351(psmb8)

GAF:	122843208 122844004

PPRL:

129375882(psmb8a)

CVG:	107104176 107104819(psmb8)

CTUL:

119794974(psmb8a)

GMU:	124879565(psmb8a)

NFU:	107394859(psmb8)

KMR:	108242638(psmb8a)

ALIM:

106519544(psmb8)

NWH:	119425619(psmb8a)

LTU:	140274537(psmb8a)

MCEP:

125019831(psmb8a)

AOCE:

111584577(psmb8a)

EJA:	138209899(psmb8a)

BFRE:

138614660(psmb8a)

LCF:	108881903 108888424

CSEM:

103393841(psmb8)

POV:

109646446

SSEN:

122761152(psmb8a)

SSOE:

131446923(psmb8a)

HHIP:

117770991(psmb8a)

HSP:	118124648(psmb8a)

PPLT:

128461393(psmb8a)

SMAU:

118292362(psmb8a)

SDU:	111239427(psmb8)

SLAL:

111661206(psmb8)

XGL:	120786281(psmb8a)

BPEC:

110173314(psmb8)

ENY:	140362162(psmb8a)

BSPL:

114866161(psmb8a)

SJO:	128374436(psmb8a)

SSCO:

133996502(psmb8a)

TTY:	137198357(psmb8a)

GMH:	115535292(psmb8)

SASA:

100136367(psmb8b) 106588400(LMP7)

STRU:

115173547 115175922(psmb8a)

OTW:	112229809(psmb8a) 112264790

OMY:	100305311(psb8) 110488347(psmb8a)

OGO:	124012337 124018411 124043536

ONE:	115128384 115131616

OKI:	109903607 109907528

OKE:	118398188 118398948

OMM:	135549972 135552221

OCLA:

139372317 139372625 139391642

SALP:

111954717 111954718 111955583 112075852

SNH:	120022587 120026799 120026892 120026894

SFON:

129819743 129831238(psmb8a)

CCLU:

121571578 121585769 121586459 123482657 123486451

ELS:

105009104

OEP:	134040660(psmb8a)

SFM:	108930382(psmb8)

PKI:

111835645

AANG:

118232974(psmb8a)

AROT:

135262097(psmb8a)

CCOG:

133136794(psmb8a)

LOC:

102683700

PSPA:

121304325(psmb8a)

ARUT:

117434213

LCM:	102358775(PSMB8)

CMK:

103171674

RTP:	109939102 125486905

CPLA:

122541277(psmb8a)

CPUN:

140455516 140455520 140455602

HOC:	132832858(psmb8a)

LERI:

129694456(psmb8a)

HAKA:

140737741(psmb8a)

PMRN:

LRJ:

LSAX:

HCRA:

LJP:

LLON:

HSY:

Reference

PMID:16181324

Authors

Strehl B, Seifert U, Kruger E, Heink S, Kuckelkorn U, Kloetzel PM

Title

Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing.

Journal

Immunol Rev 207:19-30 (2005)
DOI:10.1111/j.0105-2896.2005.00308.x

Reference

PMID:21881205

Authors

Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley DM, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, Yasutomo K

Title

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans.

Journal

J Clin Invest 121:4150-60 (2011)
DOI:10.1172/JCI58414

Sequence

[hsa:5696]

LinkDB

DBGET integrated database retrieval system