KEGG ORTHOLOGY: K03993

ORTHOLOGY: K03993

Entry

K03993                      KO

Symbol

MASP2

Name

mannan-binding lectin serine protease 2 [EC:3.4.21.104]

Pathway

map04610

Complement and coagulation cascades

map05150

Staphylococcus aureus infection

map05171

Coronavirus disease

Disease

H00105

Mannose-binding lectin pathway component defects

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03993  MASP2; mannan-binding lectin serine protease 2
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease
    K03993  MASP2; mannan-binding lectin serine protease 2
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K03993  MASP2; mannan-binding lectin serine protease 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03993  MASP2; mannan-binding lectin serine protease 2
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.104  mannan-binding lectin-associated serine protease-2
     K03993  MASP2; mannan-binding lectin serine protease 2
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K03993  MASP2; mannan-binding lectin serine protease 2

Genes

HSA:	10747(MASP2)

PTR:	107974877(MASP2)

GGO:	101126677(MASP2)

PPYG:

129008010(MASP2)

NLE:	100593253(MASP2)

SSYN:

129472591(MASP2)

MCC:	722714(MASP2)

MTHB:

126953042

MNI:	105473143(MASP2)

CSAB:

103225618(MASP2)

CATY:

105580873(MASP2)

TGE:	112616993 112617028

MLEU:

105551392(MASP2)

RRO:	104654364(MASP2)

RBB:	108539381(MASP2)

TFN:	117093329(MASP2)

CANG:

105507351(MASP2)

CJC:	100408774(MASP2)

SBQ:	101047723(MASP2)

CIMI:

108286264(MASP2)

ANAN:

105731700(MASP2)

CSYR:

103252233(MASP2)

MMUR:

105886046(MASP2)

LCAT:

123634484(MASP2)

ERUF:

138390445(MASP2)

PCOQ:

105824943(MASP2)

OGA:	100957137(MASP2)

MMU:	17175(Masp2)

MCAL:

110292278(Masp2)

MPAH:

110323473(Masp2)

RNO:	64459(Masp2)

MCOC:

116097019(Masp2)

ANU:	117709627(Masp2)

ASYL:

127680440(Masp2)

MUN:	110548141(Masp2)

CGE:	100756295 100770654

MAUA:

101832736(Masp2)

PROB:

127213461(Masp2)

PLEU:

114709641(Masp2)

PMAV:

102907907(Masp2)

MORG:

121441736 121447947

MFOT:

126508122

AAMP:

119817659(Masp2)

NGI:	103733193(Masp2)

HGL:	101696699(Masp2) 101706103

CPOC:

100725747(Masp2)

CCAN:

109689658(Masp2)

DORD:

105998488(Masp2)

DSP:	122121477(Masp2)

DMER:

138838165(Masp2)

PLOP:

125354218(Masp2)

NCAR:

124991948

SVUL:

306662849(MASP2)

MMMA:

107155504(Masp2)

ITI:	101976388(Masp2)

OPI:	101525865(MASP2)

TUP:	102488905(MASP2)

GVR:	103599995(MASP2)

CFA:	487447(MASP2)

CLUD:

112678098(MASP2)

VVP:	112929686(MASP2)

VLG:	121496717(MASP2)

NPO:	129513480(MASP2)

AML:	100466924(MASP2)

UMR:	103666866(MASP2)

UAH:	113270516(MASP2)

UAR:	123779092(MASP2)

ELK:	111154710 111154837

LLV:

125097951

MPUF:

101678006(MASP2)

MNP:	132001148(MASP2)

MLK:	131809124(MASP2)

NVS:	122899442(MASP2)

ORO:	101362776(MASP2)

EJU:	114213204(MASP2)

ZCA:	113929755(MASP2)

MLX:	118020013(MASP2)

MANO:

123860083(MASP2)

NSU:	110575128(MASP2)

LWW:	102744838(MASP2)

FCA:	101099568(MASP2)

PYU:	121020988(MASP2)

PCOO:

112848901(MASP2)

PBG:	122479914(MASP2)

PVIV:

125172279(MASP2)

LRUF:

124514805

LGF:	123597170(MASP2)

AJU:

106984902

PPAD:

109274100(MASP2)

PUC:

125913127

HHV:	120233611(MASP2)

CCRU:

144231388(MASP2)

BTA:	505819(MASP2)

BOM:	102280596(MASP2)

BIU:	109570390(MASP2)

BJV:	133227800(MASP2)

BBUB:

102414667(MASP2)

BKE:	129654279(MASP2)

BBIS:

104995849(MASP2)

CHX:	102169785(MASP2)

OCAN:

138416059(MASP2)

BTAX:

128061261(MASP2)

CSUM:

138090837(MASP2)

ODA:	120880210(MASP2)

CCAD:

122451961(MASP2)

MREE:

136168382(MASP2)

OVR:	110135868(MASP2)

MBEZ:

129551528(MASP2)

SSC:	100302537(MASP2)

CFR:	102513488(MASP2)

CBAI:

105070978(MASP2)

CDK:	105107020(MASP2)

VPC:	102529062(MASP2)

BACU:

103005678(MASP2)

BMUS:

118891774(MASP2)

LVE:	103083615(MASP2)

OOR:	101283337(MASP2)

LALB:

132515239(MASP2)

DDP:	132427036(MASP2)

SCOO:

307192481(MASP2)

DLE:	111187114(MASP2)

PCAD:

102973281(MASP2)

PSIU:

116758848(MASP2)

PPHC:

136140949(MASP2)

NASI:

112402835(MASP2)

HAMP:

307063542(MASP2)

ECB:	100056770(MASP2)

EPZ:	103552243(MASP2)

EAI:	106836680(MASP2)

MYB:

102255311

MYD:	102764933(MASP2)

MMYO:

118675853(MASP2)

MLF:	102438779(MASP2)

MDT:	132231692(MASP2)

MYUM:

139002861

EFUS:

103295319(MASP2)

POTS:

308239343(MASP2)

MNA:	107540993(MASP2)

DRO:	112299103(MASP2)

SHON:

118986356(MASP2)

AJM:	119064148(MASP2)

PDIC:

114496855(MASP2)

PHAS:

123831604(MASP2)

MMF:	118626289(MASP2)

HAI:	109381284(MASP2)

RFQ:	117026790(MASP2)

PALE:

102885750(MASP2)

PGIG:

120585827(MASP2)

PVP:	105294376(MASP2)

RAY:	107513106(MASP2)

MJV:	108401888(MASP2)

TOD:	119235574(MASP2)

SARA:

101554126(MASP2)

SFUM:

130020303(MASP2)

SETR:

126011509(MASP2)

LAV:	100662293(MASP2)

TMU:

101342871

ETF:	101640903(MASP2)

DNM:	101436761(MASP2)

MDO:	100018957(MASP2)

GAS:	123240961(MASP2)

SHR:	100932261(MASP2)

TVP:	118838985(MASP2)

PBRV:

138153857(MASP2)

MLAO:

141509157(MASP2)

OAA:	100079601(MASP2)

TACU:

119928716(MASP2)

GGA:	407089(MASP2)

PCOC:

116242633(MASP2)

MGP:	100547191(MASP2)

CJO:	107323403(MASP2)

TPAI:

128084868(MASP2)

LMUT:

125703296(MASP2)

NMEL:

110408613(MASP2)

APLA:

101801331(MASP2)

AACU:

137843301(MASP2)

OJA:	118177150(MASP2)

BCLA:

308452071(MASP2)

CATA:

118253235(MASP2)

AFUL:

116497751(MASP2)

GFR:	102032737(MASP2)

ACOE:

138121582(MASP2)

ACHC:

115342613(MASP2)

AGEN:

126041602

BBUT:

142030901(MASP2)

GCL:

127024699

MNB:	103777749(MASP2)

BRHI:

104492920(MASP2)

EGZ:	104133133(MASP2)

PARX:

142066490(MASP2)

PADL:

103917979(MASP2)

AFOR:

103907454(MASP2)

CBOY:

140661731(MASP2)

MAME:

142418474(MASP2)

MUI:	104539649(MASP2)

BREG:

104642270(MASP2)

AAM:	106482473(MASP2)

ASN:	102370755(MASP2)

CPOO:

109314472(MASP2)

GGN:	109293678(MASP2)

PSS:	102453425(MASP2)

CIZ:	142025633(MASP2)

CMY:	102929438(MASP2)

CCAY:

125624353(MASP2)

LKP:	140900254(MASP2)

NDS:	142000805(MASP2)

DCC:	119844997(MASP2)

CPIC:

101950973(MASP2)

TST:	117868098(MASP2)

CABI:

116821926(MASP2)

MRV:	120387680(MASP2)

EMQ:	137165896(MASP2)

ASAO:

132764801(MASP2)

PVT:	110073231(MASP2)

SUND:

121936757(MASP2)

PBI:	103053568(MASP2)

PMUR:

107295524(MASP2) 107301108

CTIG:

120319234(MASP2)

TSR:	106548091(MASP2)

PCAE:

139326149(MASP2)

APRI:

131186963(MASP2)

PTEX:

113446212(MASP2) 113454572 113454573

NSS:	113423143(MASP2)

VKO:	123030990(MASP2)

PMUA:

114602450(MASP2)

PRAF:

128419797(MASP2)

ZVI:	118087952(MASP2)

HCG:	128338565(MASP2)

GJA:	107124364(MASP2)

STOW:

125445616(MASP2)

EMC:	129344574(MASP2)

XLA:	108696362(masp2.L) 373654(masp2.S)

XTR:	496446(masp2)

NPR:

108789090

RTEM:

120915654(MASP2)

ACAT:

141111299(MASP2)

PADS:

140341311(MASP2)

BBUF:

120999375(MASP2)

BGAR:

122928835(MASP2) 122928836

DTC:	141097696(MASP2)

PWL:	138301107(MASP2)

MUO:	115456500(MASP2)

GSH:	117349135(MASP2)

DRE:	560277(masp2)

DAES:

130217731(masp2)

SRX:

107708846

SANH:

107681988(masp2)

SGH:

107571531

CCAR:

109048441(masp2)

CAUA:

113041489(masp2) 113076023

CGIB:

128012183

PTET:

122329124 122360201

LROH:

127154654(masp2)

GRF:	141291324(masp2)

OMC:	131532684(masp2)

PPRM:

120463137(masp2)

RKG:	130073814(masp2)

SCEP:

307145698(masp2)

MAMB:

125260255(masp2)

CIDE:

127504819

CERY:

137009586(masp2) 137034031

MASI:

127419160

TROS:

130545325(masp2)

TDW:	130409754(masp2)

MANU:

129430545(masp2)

PDAB:

135775418(masp2)

IPU:	108268542 108276220

IFU:	128619649(masp2) 128622095

PHYP:

113530393(masp2)

TFD:	113658081(masp2)

TVC:	132862523(masp2)

CGAR:

128510553(masp2)

NGRA:

132895954(masp2)

TRN:	134333544(masp2)

AMEX:

103023364(masp2)

CMAO:

118820650 118821950(masp2)

EEE:	113581290(masp2)

CHAR:

105898960(masp2) 105901607

SPIL:

134082260(c1s.2) 134087884(masp2)

ASAD:

121712927(masp2)

TRU:	101078225(masp2)

TFS:	130530648(masp2)

NCC:	104954130(masp2)

TBEN:

117494397(masp2)

CGOB:

115011239(masp2)

PGEO:

117449836(masp2)

GACU:

117541744(masp2) 117548020

EMAC:

134862787(masp2)

ELY:	117257906(masp2)

EFO:	125892337(masp2)

PLEP:

121947425(masp2)

SLUC:

116041034(masp2)

ECRA:

117947982(masp2)

ESP:	116692723(masp2)

PFLV:

114558539(masp2)

GAT:	120829410(masp2)

PPUG:

119223689(masp2)

AFB:	129099962(masp2)

CLUM:

117733828(masp2) 117741439(masp1)

PSWI:

130199463(masp2)

CANA:

137800863(masp2)

CVE:	137889524(masp2)

MSAM:

119905737(masp2)

SCHU:

122883155(masp2)

EARM:

139288507(masp2)

CUD:	121517697(masp2)

SPUL:

138589358(masp2)

LMIX:

132989408(masp2)

HTC:	141798797(masp2)

ALAT:

119022226(masp2)

ASTR:

137613042(masp2)

MZE:	101487177(masp2)

ONL:	100703975(masp2)

OAU:	116309673(masp2)

OLA:	101160657(masp2)

OML:	112159086(masp2)

CSAI:

133457296(masp2)

XMA:	102226518(masp2)

XCO:	114141728(masp2) 114142162

XHE:	116719480(masp2)

PRET:

103467229(masp2)

PFOR:

103138924(masp2)

PLAI:

106949124(masp2)

PMEI:

106919908(masp2)

GAF:	122834630(masp2)

PPRL:

129372242(masp2)

CVG:

107086886

CTUL:

119797085(masp2)

GMU:	124861211(masp2)

NFU:	107379963 107390742(masp2)

KMR:	108236764(masp2)

ALIM:

106536928

NWH:	119417291(masp2)

LTU:	140272301(masp2)

MCEP:

125023627(masp2)

AOCE:

111566407(masp2)

EJA:	138193295(masp2)

BFRE:

138615405(masp2)

LCF:

108876586

CSEM:

103384955(masp2)

POV:	109630666(masp2)

SSEN:

122777836(masp2)

SSOE:

131469049(masp2)

HHIP:

117764396(masp2)

HSP:	118111233(masp2)

PPLT:

128441911(masp2)

SMAU:

118317568(masp2)

SDU:	111219203(masp2)

SLAL:

111670573(masp2)

XGL:	120803440(masp2)

HCQ:	109526567(masp2)

SSCV:

125988621(masp2)

SBIA:

133494984(masp2)

PEE:	133413894(masp2)

PTAO:

133482226(masp2)

BPEC:

110164865(masp2)

ENY:	140363620(masp2)

MALB:

109968959(masp2)

BSPL:

114858640(masp2)

SJO:	128357769(masp2)

SSCO:

133988080(masp2)

TTY:	137184348(masp2)

GMH:	115543654(masp2)

SASA:

106572058(masp2) 106597909 106605730

STRU:

115165925(masp2)

OTW:	112232616(masp2)

OMY:	110532320(masp2)

OGO:	124031969(masp2)

ONE:	115132195(masp2)

OKI:	109908028(masp2)

OKE:	118360998(masp2)

OMM:	135504374(masp2)

OCLA:

139416529

SALP:

111966480(masp2)

SNH:	120059317(masp2)

SFON:

129830116(masp2)

CCLU:

121538378(masp2)

ELS:	105022975(masp2)

OEP:	134019412(masp2)

SFM:	108923279(masp2)

PKI:	111834328(masp2)

AANG:

118207316(masp2)

AROT:

135235052(masp2)

CCOG:

133138830(masp2)

LOC:	102693055(masp2)

PSPA:

121328317 121329011(masp2)

ARUT:

117425426 117432094

PSEX:

120531008

LCM:	102360645(MASP2)

SCLV:

120328637

CLEP:

143450047 143450049

AFIL:

140156576

PFLL:

139118742 139137092 139147235

PTEP:

107450699

ABRU:

129985168

SDM:

118204575

LGI:	LOTGIDRAFT_164015

HRJ:

124252926

» show all

Reference

PMID:10946292

Authors

Matsushita M, Thiel S, Jensenius JC, Terai I, Fujita T.

Title

Proteolytic activities of two types of mannose-binding lectin-associated serine protease.

Journal

J Immunol 165:2637-42 (2000)
DOI:10.4049/jimmunol.165.5.2637

Sequence

[hsa:10747]

Reference

PMID:9087411

Authors

Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC.

Title

A second serine protease associated with mannan-binding lectin that activates complement.

Journal

Nature 386:506-10 (1997)
DOI:10.1038/386506a0

Sequence

[hsa:10747]

LinkDB

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