KEGG ORTHOLOGY: K04123

KEGG

ORTHOLOGY: K04123

Entry

K04123                      KO

Symbol

KAO, CYP88A

Name

ent-kaurenoic acid monooxygenase [EC:1.14.14.107]

Pathway

Diterpenoid biosynthesis

Metabolic pathways

Biosynthesis of secondary metabolites

Module

Gibberellin A12 biosynthesis, plants, GAPP => GA12

Reaction

ent-kaur-16-en-19-oate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating)

ent-kaur-16-en-19-oate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating)

ent-kaur-16-en-19-oate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating)

ent-kaur-16-en-19-oate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating)

ent-kaur-16-en-19-oate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K04123  KAO, CYP88A; ent-kaurenoic acid monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K04123  KAO, CYP88A; ent-kaurenoic acid monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.107  ent-kaurenoic acid monooxygenase
     K04123  KAO, CYP88A; ent-kaurenoic acid monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, plant type
  CYP88 family
   K04123  KAO, CYP88A; ent-kaurenoic acid monooxygenase

Other DBs

GO:

Genes

OSA:	4339885(CYP88A5)

DOSA:

OBR:

OGL:

BDI:	100829065 100834068 100840895

ATS:

TDC:	119288209 119334757

TAES:

100859955 123088429 123152052

HVG:

LPER:

LRD:	124667563 124684951 124705881

SBI:

ZMA:	103639316 542580

MFLO:

136520709 136527894 136527895 136527917 136537289

SITA:

101759375 101783481

SVS:	117859799 117866907

PVIR:

120652866 120678416 120689309 120691937 120711185

PHAI:

112876728 112896230

PAUA:

133926102 133931005

TANG:

140771306 140772259

PDA:	103706434 103714070

EGU:	105055009 105059578

MUS:	135608345 135625659

ZOF:	121973813 121973815 121975874 121977793 122002203 122006465

DCT:

PEQ:

AOF:

ATH:	AT1G05160(CYP88A3) AT2G32440(KAO2)

ALY:	9315456 9328332

CRB:	17888804 17900740

CSAT:

104700214 104739049 104749619 104754659 104786342

EUS:	EUTSA_v10009356mg EUTSA_v10016575mg

BRP:	103844165 103867649

BNA:	106371084 106401854 106440494 106451319

BOE:	106292794 106337055

RSZ:	108807314 108842714

THJ:

CPAP:

110806979 110806985 110806992 110807004 110808789 110808793

CIT:	102613483 102613777 102614081 102629702

CIC:	CICLE_v10019986mg CICLE_v10031341mg CICLE_v10031862mg

PVY:	116117511 116134245 116146821 116146829

MINC:

123208728 123209742 123210303 123216284 123222953

TCC:	18585699 18606079 18606081 18606329

GRA:	105772884 105791949 105791951

GHI:	107900560 107918643 107918755 107919125 107933259 107933542 107962110 121204615

GAB:	108460315 108462417 108468286 108469217 108469308

HSYR:

120115073 120128206 120128234 120128417 120135153 120151789 120154041 120164160 120194368 120199482 120199484 120199485 120199486 120199487 120200624 120204184 120209995 120218103

DZI:	111290800 111290999 111296387 111318451

EGR:	104441311 104442000 104442001 104442002 104443188

RARG:

GMX:	100775911 100781238 100813185

GSJ:	114368869 114385768 114422894

PVU:	137809577 137831988 137831989

VRA:	106774485 106774855 106777479

VAR:	108335602 108340942 108341178 108341206

VUN:	114174667 114187411 114188643

VUM:	124823460 124849069 124849074 124849081

CCAJ:

109811458 109811471

APRC:

113848895 113852227 113859968 113869803 113874179

MTR:	11421816 25486343 25486344

TPRA:

123894420 123894421 123895690 123895691 123895692 123900978 123908724

CAM:	101498233 101511470 101512107

PSAT:

127074744 127074755

VVO:	131595340 131599817 131635548 131635549 131635550

LJA:	130724325 130724511 130724639 130726038 130731919 130732113 130740974

ADU:	107481709 107483271 107487552 107488636

AIP:	107631569 107631570 107638943

AHF:	112734534 112734535 112741528 112747996 112789995 112792330 112800419 112801238

LANG:

109330360 109330361 109332646 109333650 109341805 109350837

PCIN:

129284890 129288428 129289165 129289688 129304819 129323184

QSA:	O6P43_017136 O6P43_017453 O6P43_024466 O6P43_026842

FVE:	101296899 101305225 101305520 101310426

AANS:

126802334 126802335 126803528

RCN:	112173065 112179986 112181788

PPER:

18776554 18776771 18784549 18784550 18785864 18786347 18786970

PMUM:

103331385 103331394 103331395 103336931 103336981

PAVI:

110756042 110756077 110756078 110756080 110768794 110768800

PDUL:

117619068 117619515 117619538 117619561 117627601 117628494

MDM:	103407813 103418447 103420166 103438911

MSYL:

126609765 126626515 126627883

PXB:	103939254 103962469 103965514 108868325

PCOX:

137710451 137711670 137735675 137748481

ZJU:	107430468 107430486 107430487 107430488 107430491

MNT:	21406078 21406618

CSAV:

115710887 115715978

HLP:	133777945 133804678 133834111

CSV:	101220640 101221667

CMO:	103483403 103498993

BHJ:	120069265 120070042 120087126 120089459 120091820 120092881

MCHA:

111016043 111022826

CMAX:

111479695 111494707

CMOS:

111432076 111464585

CPEP:

111778200 111791498

RCU:

MEAN:

126655385 126688050

JCU:

HBR:	110637522 110640195 110652612 110673668

MESC:

110613188 110613994 110626020

POP:	7464756 7469386

PEU:	105114977 105117216

PALZ:

118049585 118063426 118063428

PNZ:	133669310 133682529

JRE:	108989523 108994022 109003471 109003472 109003488 109003490 109009223 109012176 109014771

CILL:

122274663 122275386 122279873 122280545 122291578 122294386

CAVE:

132161623 132162420 132162422 132162428 132168004 132176212

AGLU:

133854723 133854854 133872400 133879973

QSU:	111998301 112005451 112005461 112022261

QLO:	115969956 115970103 115970145 115970147 115987237

CSAA:

142612662 142612868 142613755 142613787 142617666

TWL:	119979992 119982481 119983960 119985407 119985773 119985774 119985775 119985776 119985777 119988718 119993269 120003355 120003579 120014376 120014753 120016863 120017323 120017327

VVI:	100246155 100251295

VRI:	117931586 117931588

SLY:

SPEN:

SOT:

SSTN:

SDUL:

129886826 129895083 129900283

SVER:

CANN:

107844151 107874876

LBB:	132609747 132615234 132645157

NTA:	107780044 107794300

NSY:	104236038 104249779

NTO:

NAU:

INI:	109155636 109156226 109156227 109156441 109156442 109163950 109163954 109178961

ITR:	115996900 116028387 116030480

SIND:

105167146 105173422

OEU:	111384195 111394261

EGT:	105952437 105954785

SSPL:

121774509 121776503 121792617 121800621 121806353

SMIL:

131015853 131015858 131015860 131022156 131022159

SHIS:

125185352 125196715 125202130 125202734

APAN:

127246080 127260462

PEBU:

140809787 140822086

PTAB:

142506009 142546864 142551921

CARB:

113703285 113706525 113727005 113727007 113727008 113732091 113732092 113732094

HAN:

BHW:	143584506 143603633

ECAD:

122595978 122598468

LSV:	111879980(LOC111879980)

CCAV:

DCR:	108200404 108206454

AGRV:

141661581 141695695 141724333

CSIN:

114264635 114274344

RVL:

AEW:	130783986 130794233

DLT:

BVG:	104892989 104905197 104905198

SOE:	110790693 110793291 110793292

CQI:	110692430 110702167 110720433 110720434

ATRI:

130800751 130809742

SLAF:

141585936 141630389 141643914

MOF:	131166139 131166142

NNU:	104606451 104610396

MING:

122086087 122087349

TSS:	122645731 122663933

PSOM:

MSIN:

131233207 131248159

ACAK:

NCOL:

ATR:

CJF:

SMO:	SELMODRAFT_103517(CYP88E1) SELMODRAFT_115926 SELMODRAFT_127900(CYP88E2) SELMODRAFT_1840 SELMODRAFT_86321(CYP88F1)

Reference

PMID:11172076 (CYP88A3 CYP88A4)

Authors

Helliwell CA, Chandler PM, Poole A, Dennis ES, Peacock WJ

Title

The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway.

Journal

Proc Natl Acad Sci U S A 98:2065-70 (2001)
DOI:10.1073/pnas.041588998

Sequence

[ath:AT1G05160 AT2G32440]

LinkDB

DBGET integrated database retrieval system