KEGG   ORTHOLOGY: K04128
Entry
K04128                      KO                                     
Symbol
cmcH
Name
hydroxymethyl cephem carbamoyltransferase [EC:2.1.3.7]
Pathway
map00311  Penicillin and cephalosporin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00673  Cephamycin C biosynthesis, aminoadipate + cycteine + valine => cephamycin C
Reaction
R05230  carbamoyl-phosphate:deacetylcephalosporin C carbamoyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00311 Penicillin and cephalosporin biosynthesis
    K04128  cmcH; hydroxymethyl cephem carbamoyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K04128  cmcH; hydroxymethyl cephem carbamoyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.7  3-hydroxymethylcephem carbamoyltransferase
     K04128  cmcH; hydroxymethyl cephem carbamoyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Nonribosomal peptide tailoring proteins
  Others
   K04128  cmcH; hydroxymethyl cephem carbamoyltransferase
Other DBs
GO: 0047155
Genes
SANL: KZO11_35585
SCLF: BB341_07765
SFIY: F0344_19625
SCT: SCAT_5682(cmcH)
SCY: SCATT_56820
THAO: NI17_008625
AAB: A4R43_03245
AMYY: YIM_39160(novN2)
Reference
PMID:7557411
  Authors
Coque JJ, Perez-Llarena FJ, Enguita FJ, Fuente JL, Martin JF, Liras P
  Title
Characterization of the cmcH genes of Nocardia lactamdurans and Streptomyces clavuligerus encoding a functional 3'-hydroxymethylcephem O-carbamoyltransferase  for cephamycin biosynthesis.
  Journal
Gene 162:21-7 (1995)
DOI:10.1016/0378-1119(95)00308-s
Reference
PMID:9696752
  Authors
Alexander DC, Jensen SE
  Title
Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein.
  Journal
J Bacteriol 180:4068-79 (1998)
DOI:10.1128/JB.180.16.4068-4079.1998
  Sequence
[sclf:BB341_07765]
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