KEGG ORTHOLOGY: K04140

ORTHOLOGY: K04140

Entry

K04140                      KO

Symbol

ADRA2C

Name

adrenergic receptor alpha-2C

Pathway

map04022

cGMP-PKG signaling pathway

map04080

Neuroactive ligand-receptor interaction

map04081

Hormone signaling

map04082

Neuroactive ligand signaling

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    K04140  ADRA2C; adrenergic receptor alpha-2C
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04140  ADRA2C; adrenergic receptor alpha-2C
   04082 Neuroactive ligand signaling
    K04140  ADRA2C; adrenergic receptor alpha-2C
   04081 Hormone signaling
    K04140  ADRA2C; adrenergic receptor alpha-2C
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04140  ADRA2C; adrenergic receptor alpha-2C
G protein-coupled receptors [BR:ko04030]
Rhodopsin family
  Biogenic amine
   Adrenaline
    K04140  ADRA2C; adrenergic receptor alpha-2C

Other DBs

GO:

0004938

Genes

HSA:	152(ADRA2C)

PTR:	465178(ADRA2C)

PPS:	100993507(ADRA2C)

GGO:	101153693(ADRA2C)

PON:	100938399(ADRA2C)

PPYG:

129035602(ADRA2C)

NLE:	100591173(ADRA2C)

SSYN:

129464466(ADRA2C)

MCC:	719763(ADRA2C)

MCF:	102129584(ADRA2C)

MTHB:

126955499

MNI:	105483877(ADRA2C)

CSAB:

103246439(ADRA2C)

CATY:

105585526(ADRA2C)

PANU:

100997498(ADRA2C)

TGE:	112624958(ADRA2C)

MLEU:

105555318(ADRA2C)

RRO:	104678965(ADRA2C)

RBB:

108525445

TFN:	117085080(ADRA2C)

PTEH:

111539101(ADRA2C)

CANG:

105507076(ADRA2C)

CJC:	108590995(ADRA2C)

CIMI:

108311582(ADRA2C)

ANAN:

105705260(ADRA2C)

MMUR:

105860246(ADRA2C)

LCAT:

123622124(ADRA2C)

PCOQ:

105818899(ADRA2C)

OGA:	100964286(ADRA2C)

MMU:	11553(Adra2c)

MCAL:

110295362(Adra2c)

MPAH:

110330905(Adra2c)

RNO:	24175(Adra2c)

MCOC:

116069086(Adra2c)

ANU:	117712753(Adra2c)

ASYL:

127696456(Adra2c)

MUN:	110562357(Adra2c)

CGE:	103161652(Adra2c)

MAUA:

101842237(Adra2c)

PROB:

127233727(Adra2c)

PLEU:

114702047(Adra2c)

MORG:

121436591 121459886

MFOT:

126500681

AAMP:

119803357(Adra2c)

NGI:	103741158(Adra2c)

HGL:	101723218(Adra2c)

CPOC:

101787589(Adra2c)

CCAN:

109687429(Adra2c)

DORD:

105991275(Adra2c)

DSP:	122100678(Adra2c)

DMER:

138826470(Adra2c)

PLOP:

125345077 125364710(Adra2c)

NCAR:

124994623

MMMA:

107138903(Adra2c)

TUP:	102499472(ADRA2C)

CFA:	488793(ADRA2C)

CLUD:

112653635(ADRA2C)

VVP:	112922690(ADRA2C)

VLG:	121490069(ADRA2C)

NPO:	129510402(ADRA2C)

AML:	100467814(ADRA2C)

UMR:	121101404 121101419

UAH:	113245678(ADRA2C)

UAR:	123775565(ADRA2C)

ELK:

111149310

LLV:

125093497

MNP:	132014996(ADRA2C)

MLK:	131826727(ADRA2C)

NVS:	122890008(ADRA2C)

ORO:	101373984(ADRA2C)

EJU:	114198629(ADRA2C)

ZCA:	113924836(ADRA2C)

LWW:	102735145(ADRA2C)

FCA:	101087990(ADRA2C)

PBG:	122479099(ADRA2C)

PVIV:

125159223(ADRA2C)

LRUF:

124522674

LGF:	123596238(ADRA2C)

AJU:

106978827

PTG:

107179003

PPAD:

109269734(ADRA2C)

PLEZ:

122217268(ADRA2C)

HHV:	120231815(ADRA2C)

BTA:	407139(ADRA2C)

BOM:	102285813(ADRA2C)

BBUB:

102391525(ADRA2C)

CHX:	102181288(ADRA2C)

OAS:	100170319(ADRA2C)

BTAX:

128049843(ADRA2C)

CSUM:

138082186(ADRA2C)

ODA:	120861810(ADRA2C)

CCAD:

122428358(ADRA2C)

MREE:

136152838(ADRA2C)

OVR:	139033423(ADRA2C)

MBEZ:

129562060(ADRA2C)

SSC:	733706(ADRA2C)

CFR:	102520676(ADRA2C)

CBAI:

105072595(ADRA2C)

CDK:	105103347(ADRA2C)

VPC:	102538622(ADRA2C)

BACU:

103008893(ADRA2C)

BMUS:

118896142(ADRA2C)

LVE:	103074700(ADRA2C)

OOR:	101288539(ADRA2C)

LALB:

132519531(ADRA2C)

GMF:	115863759(ADRA2C)

DLE:	111164863(ADRA2C)

PCAD:

112063759(ADRA2C)

PSIU:

116753844(ADRA2C)

PPHC:

136123559(ADRA2C)

NASI:

112399742(ADRA2C)

ECB:	111772982(ADRA2C)

EPZ:	139082408(ADRA2C)

EAI:	106840085(ADRA2C)

MYB:	102249134(ADRA2C)

MYD:	102767191(ADRA2C)

MMYO:

118666073(ADRA2C)

MDT:	132221837(ADRA2C)

MYUM:

139007692(ADRA2C)

PKL:	118707179(ADRA2C)

EFUS:

103294559(ADRA2C)

MNA:	107524104(ADRA2C)

DRO:	112316673(ADRA2C)

SHON:

118987405(ADRA2C)

AJM:	119035536(ADRA2C)

PDIC:

114489956(ADRA2C)

PHAS:

123815656(ADRA2C)

MMF:	118616503(ADRA2C)

PPAM:

129077667(ADRA2C)

RFQ:	117021966(ADRA2C)

PALE:

102895430(ADRA2C)

PGIG:

120582736(ADRA2C)

PVP:	105301231(ADRA2C)

RAY:	107499758(ADRA2C)

MJV:	108397478(ADRA2C)

TOD:	119260859(ADRA2C)

SFUM:

130040794(ADRA2C)

SETR:

126032391(ADRA2C)

LAV:	100668918(ADRA2C)

MDO:	100020740(ADRA2C)

GAS:	123251637(ADRA2C)

SHR:	100927538(ADRA2C)

AFZ:

127539816

PCW:	110212274(ADRA2C)

TVP:	118854024(ADRA2C)

PBRV:

138148019(ADRA2C)

OAA:	100090717(ADRA2C)

GGA:	427631(ADRA2BL2) 428799(ADRA2C)

PCOC:

116225768(ADRA2C) 116231902

MGP:	100550610 104909214(ADRA2C)

CJO:	107314070(ADRA2C) 107320469

TPAI:

128080475(ADRA2C) 128081638

LMUT:

125692767(ADRA2C) 125700259

NMEL:

110398809(ADRA2C) 110405283

APLA:

101790023(ADRA2C)

ACYG:

106033335(ADRA2C) 125184920

CATA:

118248430(ADRA2C) 118254509

AFUL:

116488621(ADRA2C) 116494779

TGU:	101232953 101233463(ADRA2C)

LSR:	110470815 110481882(ADRA2C)

SCAN:

103817516 103826124 115485332

PMOA:

120498598 120511618

OTC:	121332523 121335207(ADRA2C)

PRUF:

121349093(ADRA2C) 121361350

ATRC:

139597820 139599723(ADRA2C)

GFR:	102039660(ADRA2C)

FAB:	101809146 101811765(ADRA2C)

OMA:	130252741(ADRA2C) 130258703

PHI:	102102017 102111432(ADRA2C)

PMAJ:

107203559(ADRA2C) 107210518

CCAE:

111928227(ADRA2C)

CCW:	104690916(ADRA2C)

CBRC:

103611180(ADRA2C)

ACOE:

138109997(ADRA2C) 138118205

ETL:	114061213(ADRA2C) 114066275

ZAB:	102071646(ADRA2C)

ZLE:	135446469(ADRA2C) 135453642

ACHL:

103807563(ADRA2C)

SVG:	106852923 106865308(ADRA2C)

MMEA:

130573092(ADRA2C) 130580786

HRT:	120752932(ADRA2C) 120759273

SATI:

136360291(ADRA2C) 136367590

CCIC:

134044229(ADRA2C) 134049569

FPG:	101915995 101919690(ADRA2C)

FCH:	102053781(ADRA2C) 102054211

CCRI:

104156583(ADRA2C)

NNT:	104413409(ADRA2C)

SHAB:

115610796(ADRA2C) 115616074

ACUN:

113479387(ADRA2C) 113485271

TALA:

104356590(ADRA2C) 116964756

ACHC:

115334141 115346424(ADRA2C)

HALD:

104322659(ADRA2C)

HLE:	104841680(ADRA2C)

AGEN:

126033938 126050946

HHAR:

128138896(ADRA2C) 128155074

GCL:	127015968 127021938

CSTI:

104549419(ADRA2C)

LDI:	104353767(ADRA2C)

MNB:	103782518(ADRA2C)

DPUB:

104304002 104307941(ADRA2C)

PPUS:

135179611(ADRA2C) 135185271

AVIT:

104280412(ADRA2C)

BRHI:

104497377(ADRA2C)

EGZ:	104130208(ADRA2C)

NNI:	104018051(ADRA2C) 104019003

PCRI:

104030211(ADRA2C)

PCAO:

104046695(ADRA2C)

PADL:

103920994(ADRA2C)

AFOR:

103904077(ADRA2C) 103904515

FGA:	104083435(ADRA2C)

GSTE:

104257582(ADRA2C)

CBOY:

140651807(ADRA2C) 140656558

CLV:	102083610 102097195(ADRA2C)

CNIC:

135988350(ADRA2C) 135994106

MUI:

104541410

PGUU:

104471414(ADRA2C)

PLET:

104624725(ADRA2C)

EHS:	104505043(ADRA2C)

CMAC:

104475094(ADRA2C)

CUCA:

104062564(ADRA2C) 104065591

TEO:	104381102(ADRA2C)

BREG:

104631342(ADRA2C)

OHA:	104331106(ADRA2C)

ACAR:

104529364(ADRA2C)

CPEA:

104391046(ADRA2C) 104392661

CVF:	104291328(ADRA2C)

RTD:	128910699(ADRA2C) 128916178

CRID:

134516305(ADRA2C) 134521953

AAM:	106498672(ADRA2C)

AROW:

112964823 112974585(ADRA2C)

NPD:	112943057(ADRA2C)

TGT:	104575548(ADRA2C)

DNE:	112996516(ADRA2C) 112996889

SCAM:

104151431(ADRA2C)

ASN:	102375154(ADRA2C)

AMJ:	102568542(ADRA2C)

CPOO:

109321809(ADRA2C)

GGN:	109304122(ADRA2C)

PSS:	102447937(ADRA2C)

CMY:	102937639(ADRA2C)

CCAY:

125636213(ADRA2C) 125641273

DCC:	119855243(ADRA2C)

CPIC:

101934570(ADRA2C) 101952800

TST:	117878158(ADRA2C)

CABI:

116829689(ADRA2C)

MRV:	120405673(ADRA2C)

ASAO:

132765028 132776399(ADRA2C)

PVT:

110069786

SUND:

121918421

VKO:	123017109(ADRA2C)

PMUA:

114604723(ADRA2C)

PRAF:

128420982(ADRA2C)

ZVI:	118084204(ADRA2C)

HCG:	128325786(ADRA2C)

GJA:	107112872(ADRA2C)

STOW:

125440251(ADRA2C)

EMC:	129342903(ADRA2C)

XLA:	108697938(adra2c.L) 108705869(adra2c.S)

XTR:	100145449(adra2c)

NPR:	108783754 108785823(ADRA2C)

RTEM:

120924406(ADRA2C)

ACAT:

141117807(ADRA2C)

BBUF:

120991825(ADRA2C)

BGAR:

122927844(ADRA2C)

DTC:	141088471(ADRA2C)

PWL:	138249501(ADRA2C)

MUO:	115462586(ADRA2C)

GSH:	117363031 117367192(ADRA2C)

DRE:	266752(adra2c) 266754(adra2da) 266755(adra2db)

SRX:	107712015 107715166 107749936 107749943 107752971 107756793 107756796 107757419

SANH:

107667592 107671617 107674202 107676165 107678652 107689214

SGH:	107552592 107556512 107556841 107566213 107571248 107590063

CCAR:

109045572(adra2db) 109046092 109071900(adra2c) 109081305(adra2da) 109088051 109088966

CAUA:

113039177 113047823 113063998 113075930 113078796 113080256 113097539

CGIB:

127941724 127948440 127971062 127986419 128016868 128027700

PTET:

122326185(adra2db) 122349244(adra2c) 122357251(adra2da)

LROH:

127152026(adra2db) 127164129(adra2c) 127175784(adra2da)

GRF:	141288535(adra2da) 141337093(adra2c)

OMC:	131529125(adra2db) 131543379(adra2c) 131552994(adra2da)

PPRM:

120465343(adra2da) 120492215(adra2c) 120494482(adra2db)

RKG:	130076288(adra2c) 130095393(adra2db)

MAMB:

125253425(adra2db) 125266875(adra2da) 125272157(adra2c)

CIDE:

127494245 127503187 127519957

CERY:

137013040(adra2db) 137018847(adra2da) 137032232(adra2c)

MASI:

127417957 127429403 127431116 127443912 127445381

TROS:

130553011(adra2c) 130563349(adra2da) 130570337(adra2db)

TDW:	130408115(adra2db) 130408917(adra2c) 130438048(adra2da)

MANU:

129422763(adra2da) 129423067(adra2db) 129444341(adra2c)

PDAB:

135746624(adra2c) 135752276(adra2da) 135776954(adra2db)

IPU:	108260662 108262932 108275442 108278623(adra2db)

IFU:	128604490 128606000(adra2c) 128618402(adra2da) 128622258(adra2db)

PHYP:

113529498 113541651 113544082(adra2c) 113545716

SMEO:

124381556 124392960(adra2da) 124395471(adra2c) 124398029(adra2db)

TFD:	113635531 113642385(adra2c) 113646951(adra2db) 113654831(adra2da)

TVC:	132846736(adra2c) 132857318(adra2da) 132860009(adra2db) 132860643

CGAR:

128507221(adra2db) 128508698 128529200(adra2c) 128542020

NGRA:

132874487 132882831 132888767(adra2c) 132895041(adra2db)

TRN:	134314670(adra2c) 134319541 134326135 134330653(adra2db)

AMEX:

103025929 103033245(adra2c) 103042284 125782486(adra2db)

CMAO:

118809974(adra2c) 118812700(adra2da) 118816889 118820566(adra2db)

EEE:	113571287 113581745 113588338 113589940

CHAR:

105893714(adra2da) 105904584(adra2db) 105908371(adra2c) 105912885

SPIL:

134060586 134080780(adra2db) 134096110(adra2da) 134101053(adra2c)

TRU:	101069073 101074073 101078477 101078692

TFS:	130518698 130522614 130527821(adra2c) 130531614(adra2db)

TNG:	GSTEN00006408G001 GSTEN00019239G001 GSTEN00022631G001

LCO:	104921951 104923970 104927068 104927241

NCC:	104941496 104946199 104952645(adra2c) 104953545

TBEN:

117470865(adra2db) 117471702 117482735(adra2c) 117488161

CGOB:

115006489 115006505 115009953 115015145 115023722

PGEO:

117454070(adra2c) 117454249(adra2db) 117463845 117465870

GACU:

117533658 117537224(adra2c) 117552728 117555965(adra2db)

EMAC:

134860357(adra2db) 134863407 134864937(adra2c) 134876247

ELY:	117252436 117254990(adra2c) 117260634(adra2db) 117272884

EFO:	125884052 125885644(adra2c) 125894925(adra2db) 125901618

PLEP:

121942481(adra2c) 121944545 121948429(adra2db) 121962330

SLUC:

116039692(adra2c) 116049034 116064328(adra2db) 116067281

ECRA:

117934971 117938832 117951587(adra2db) 117953723(adra2c)

ESP:	116686383 116687118 116696637 116697400

PFLV:

114546115(adra2c) 114555554 114562898 114572862

GAT:	120812681 120818112(adra2db) 120823039 120824979(adra2c)

PPUG:

119196170 119210024(adra2db) 119217728(adra2c) 119221660

AFB:	129090166(adra2db) 129093714 129096472(adra2c) 129107279

CLUM:

117728688 117735352(adra2c) 117737401(adra2db) 117747859

PSWI:

130189513(adra2c) 130193017 130210031(adra2db) 130211881

CANA:

137786154 137788137(adra2db) 137792285 137793038(adra2c)

CVE:	137874887 137875435(adra2db) 137882222 137886586(adra2c)

MSAM:

119888593(adra2db) 119890270 119899660(adra2c) 119911751

SCHU:

122870003 122873368(adra2c) 122879989 122880382(adra2db)

CUD:	121504097(adra2c) 121513215 121515974(adra2db)

SPUL:

138594217(adra2c) 138598215 138600850 138606825

LMIX:

132958767 132973145 132981817(adra2db) 132984961(adra2c)

ALAT:

119006894(adra2db) 119017323(adra2c) 119018183 119027336

ASTR:

137590940 137595400 137600425(adra2c) 137602700(adra2db)

MZE:	101472695 101474048 101479598 101486679

ONL:	100691231(adra2c) 100708556 100712311

OAU:	116310378 116323945 116328588(adra2c) 116329093(adra2db)

OLA:	101160174 101161340(adra2c) 101164629 101169521

OML:	112141982 112145518 112153018(adra2db) 112155680

CSAI:

133419694 133420066 133420068 133447558(adra2db)

XMA:	102221126 102226842 102235708 102236027

XCO:	114138644 114143551 114143858 114156795(adra2c)

XHE:	116714922 116719269 116720793 116732046

PRET:

103462980 103464341 103471265 103480445

PFOR:

103132190 103132197 103135531 103137486 103155222

PLAI:

106937344 106945756 106949366 106951016

PMEI:

106905564 106920867 106924559 106927598 106930928(adra2c)

GAF:	122819974 122824648 122830109(adra2c) 122837137(adra2db)

PPRL:

129354875 129362402(adra2db) 129367260(adra2c)

CVG:	107091080 107093758(adra2c) 107094989 107099081

CTUL:

119777897(adra2db) 119780571 119783403 119797989(adra2c)

GMU:	124859920(adra2db) 124866678 124868696(adra2c) 124880946

NFU:	107373463 107375821 107377377 107393278

KMR:	108236301(adra2c) 108240556(adra2db) 108242333 108249957

ALIM:

106513117 106517482 106525354(adra2c) 106535232

NWH:	119408787(adra2db) 119409248 119422669(adra2c) 119430279

AOCE:

111569522(adra2db) 111570710 111576733(adra2c) 111577212

EJA:	138192306 138208194(adra2c) 138210669 138211184

BFRE:

138624580(adra2c) 138633637(adra2db) 138635443 138636522

MCEP:

125000060(adra2c) 125003972 125005497 125008706(adra2db)

CSEM:

103384182 103387343 103390990 103398493

POV:	109627750 109632596 109641432 109646613

SSEN:

122766216 122770576(adra2c) 122772642 122778146(adra2db)

SSOE:

131456886 131459108 131466997(adra2c) 131472714(adra2db)

HHIP:

117752021 117759154 117767767(adra2c) 117769582(adra2db)

HSP:	118102312 118106485 118111824(adra2db) 118117015(adra2c)

PPLT:

128430368 128437097(adra2c) 128437198 128446522(adra2db)

SMAU:

118302883 118313223(adra2c) 118319014 118319891(adra2db)

LCF:	108875561 108879967 108894164 108899273(adra2db)

SDU:	111217968 111223071 111226458 111233056

SLAL:

111646554 111656645 111664609 111673473(adra2c)

XGL:	120785050(adra2db) 120788280 120797621 120800525(adra2c)

HCQ:	109514276 109518671 109520324 109527378

SSCV:

125969058(adra2c) 125983258(adra2db) 125992553 137840251

SBIA:

133494643 133506258(adra2c) 133508882(adra2db)

PEE:	133398079 133404170(adra2c) 133407702(adra2db) 133414932 133414940

PTAO:

133472959 133473270 133473347 133476368(adra2c) 133485050(adra2db)

BPEC:

110157662 110159476 110175748

ENY:	140354310(adra2db) 140371933 140377772(adra2c)

MALB:

109957837 109971556 109973165 109974257

BSPL:

114844655 114852360 114856932(adra2c) 114864074(adra2db)

SJO:	128363252(adra2db) 128364350 128373713(adra2c) 128383853

SSCO:

133986114(adra2db) 133996148(adra2c) 133996530 134005948

GMH:	115529418(adra2c) 115552563 115558194

SASA:

106563753 106577568 106603007 106604836 106608696 106610412 106611869

STRU:

115153776 115174442 115181971 115194194 115197904 115202783 115205403

OTW:	112214969 112220759 112228191 112230624 112256085 112261049 121844636 121845046

OMY:	110488611 110500663 110504821 110510201 110514534 110531806 110534927 118936798

OGO:	123993255 123993434 124007501 124008766 124011426 124014535 124020534

ONE:	115115775 115130525 115133780 115136395 115138904 115147079

OKI:	109864634 109872732 109878743 109884757 109896462 109905998 109906270 116360058

OKE:	118369298 118375959 118376744 118382151 118385617 118390786(adra2db) 118392624

OMM:	135509952 135515380 135526226 135533048 135543857 135545730

OCLA:

139366163 139379463 139388476 139390945 139394180 139395881 139417188 139419620 139419733

SALP:

111951050 111960211 111963685 111965391 111967376 111981428

SNH:	120020915 120030217 120039905 120040006 120048198 120049228(adra2c) 120056659 120062396

CCLU:

121541264 121546869 121554524 121562599 121572703 121580264 121580311

ELS:	105020660 105020820 105020821 105024904 105025824

OEP:	134009808 134032924(adra2db) 134033669(adra2c)

SFM:	108925693 108931116 108936784

PKI:	111842631 111853067 111855457

AANG:

118224324 118227125(adra2c) 118231465 118236285

AROT:

135249833 135254429 135259968 135263621

CCOG:

133124617 133131161(adra2c) 133133838 133135471

LOC:	102694090 102695778(adra2c)

PSPA:

121296895 121301912 121323853 121327661

ARUT:

117409626 117413076 117420996

PSEX:

120527796(adra2c) 120543082(adra2db)

LCM:	102353707 102355811(ADRA2C)

CMK:	103177286 103186334(adra2c)

RTP:	109920122(adra2c) 125484538

CPLA:

122556648(adra2c) 122556809

HOC:	132823134 132829923(adra2c)

LERI:

129693889(adra2c) 129701447

HAKA:

140728862(adra2c) 140739497

PMRN:

116940578(ADRA2C) 116941367

LRJ:	133343423 133345500

BBEL:

AJJ:

AFIL:

PFLL:

PPYR:

PCHN:

PPOI:

HASI:

CRG:

CVN:	111132105 111135610

OED:	125651875 125659769

MMER:

RPHI:

DPOL:

Reference

PMID:2842764

Authors

Regan JW, Kobilka TS, Yang-Feng TL, Caron MG, Lefkowitz RJ, Kobilka BK

Title

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.

Journal

Proc Natl Acad Sci U S A 85:6301-5 (1988)
DOI:10.1073/pnas.85.17.6301

Sequence

[hsa:152]

LinkDB

DBGET integrated database retrieval system