KEGG ORTHOLOGY: K04200

ORTHOLOGY: K04200

Entry

K04200                      KO

Symbol

MC2R

Name

melanocortin 2 receptor

Pathway

map04024

cAMP signaling pathway

map04080

Neuroactive ligand-receptor interaction

map04081

Hormone signaling

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04934

Cushing syndrome

Disease

H00033

Adrenal carcinoma

H00256

Familial glucocorticoid deficiency

H02049

Bilateral macronodular adrenal hyperplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K04200  MC2R; melanocortin 2 receptor
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04200  MC2R; melanocortin 2 receptor
   04081 Hormone signaling
    K04200  MC2R; melanocortin 2 receptor
09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    K04200  MC2R; melanocortin 2 receptor
   04927 Cortisol synthesis and secretion
    K04200  MC2R; melanocortin 2 receptor
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04200  MC2R; melanocortin 2 receptor
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04200  MC2R; melanocortin 2 receptor
G protein-coupled receptors [BR:ko04030]
Rhodopsin family
  Peptide
   Melanocortin
    K04200  MC2R; melanocortin 2 receptor

Other DBs

GO:

0004977

TC:	9.A.14.2.4

Genes

HSA:	4158(MC2R)

PTR:	455500(MC2R)

PPS:	100987960(MC2R)

GGO:	101143835(MC2R)

PON:	100436726(MC2R)

PPYG:

129019016(MC2R)

NLE:	100579327(MC2R)

HMH:	116468126(MC2R)

SSYN:

129489739(MC2R)

MCC:	114673757(MC2R) 701312

MCF:	102138088(MC2R)

MTHB:

126941109

MNI:	105478947(MC2R)

CSAB:

103222835(MC2R)

CATY:

105598919(MC2R)

PANU:

101004428(MC2R)

TGE:	112611601(MC2R)

MLEU:

105543571(MC2R)

RRO:	104671837(MC2R)

RBB:	108533098(MC2R)

TFN:	117064196(MC2R)

PTEH:

111553619(MC2R)

CANG:

105507929(MC2R)

CJC:	100407128(MC2R)

SBQ:	101033240(MC2R)

CIMI:

108282479(MC2R)

ANAN:

105730995(MC2R)

CSYR:

103274320(MC2R)

MMUR:

105861032(MC2R)

LCAT:

123621850(MC2R)

ERUF:

138383404(MC2R)

PCOQ:

105814865(MC2R)

OGA:	100942974(MC2R)

MMU:	17200(Mc2r)

MCAL:

110285054(Mc2r)

MPAH:

110333383(Mc2r)

RNO:	282839(Mc2r)

MCOC:

116087705(Mc2r)

ANU:	117720200(Mc2r)

ASYL:

127664001(Mc2r)

MUN:	110562156(Mc2r)

CGE:	100757427(Mc2r)

MAUA:

101825745(Mc2r)

PROB:

127234066(Mc2r)

PLEU:

114690210(Mc2r)

MORG:

121438741(Mc2r)

MFOT:

126511095

AAMP:

119813994(Mc2r)

CNL:	130886713(Mc2r)

NGI:	103727856(Mc2r)

HGL:	101699946(Mc2r)

CPOC:

100135574(Mc2r)

CCAN:

109699704(Mc2r)

DORD:

105993800(Mc2r)

DSP:	122110993(Mc2r)

DMER:

138831624(Mc2r)

PLOP:

125363960(Mc2r)

NCAR:

124965743

MMMA:

107157646(Mc2r)

ITI:	101974962(Mc2r)

OCU:

100347821

OPI:	101533321(MC2R)

OCZ:	121166051(MC2R)

TUP:	102491977(MC2R)

GVR:	103581383(MC2R)

CFA:	100855756(MC2R)

CLUD:

112643762(MC2R)

VVP:	112919184(MC2R)

VLG:	121481880(MC2R)

NPO:	129495431 129514502

AML:	100482443(MC2R)

UMR:	103680476(MC2R)

UAH:	113245896(MC2R)

UAR:	123803577(MC2R)

ELK:

111142750

LLV:

125082654

MPUF:

101676754(MC2R)

MNP:	132023883(MC2R)

MLK:	131811807(MC2R)

NVS:	122901994(MC2R)

ORO:	101377845(MC2R)

EJU:	114198058(MC2R)

ZCA:	113912263(MC2R)

MLX:	118016419(MC2R)

MANO:

123852373(MC2R)

NSU:	110574353(MC2R)

LWW:	102744458(MC2R)

FCA:	692350(MC2R)

PYU:	121032683(MC2R)

PCOO:

112868357(MC2R)

PBG:	122471033(MC2R)

PVIV:

125149571(MC2R)

LRUF:

124519783

LGF:	123588172(MC2R)

AJU:

106979644

PTG:	102953314(MC2R)

PPAD:

109257618(MC2R)

PUC:

125914864

PLEZ:

122203760(MC2R)

HHV:	120226057(MC2R)

CCRU:

144243177(MC2R)

BTA:	281299(MC2R)

BOM:	102279724(MC2R)

BIU:	109577760(MC2R)

BBUB:

102415635(MC2R)

BKE:	129635923(MC2R)

BBIS:

105002430(MC2R)

CHX:	102182364(MC2R)

OAS:	443482(MC2R)

BTAX:

128067568(MC2R)

CSUM:

138097710(MC2R)

ODA:	120881034(MC2R)

CCAD:

122425747(MC2R)

MREE:

136167897(MC2R)

OVR:	110150668(MC2R)

MBEZ:

129549596(MC2R)

SSC:	100739231(MC2R)

CFR:	102510856(MC2R)

CBAI:

105071474(MC2R)

CDK:	105086494(MC2R)

VPC:	102533695(MC2R)

BACU:

103007152(MC2R)

BMUS:

118880171(MC2R)

LVE:	103083957(MC2R)

OOR:	101281347(MC2R)

LALB:

132504010(MC2R)

GMF:	115841993(MC2R)

DDP:	132436565(MC2R)

DLE:	111163031(MC2R)

PCAD:

102996884(MC2R)

PSIU:

116738812(MC2R)

PPHC:

136133047(MC2R)

NASI:

112412298(MC2R)

ECB:	100057018(MC2R)

EPZ:	103555005(MC2R)

EAI:	106828648(MC2R)

MYB:	102244928(MC2R)

MYD:	102753039(MC2R)

MMYO:

118663344(MC2R)

MLF:	102430904(MC2R)

MDT:	132239814(MC2R)

MYUM:

139014624(MC2R)

PKL:	118708228(MC2R)

EFUS:

103302485(MC2R)

MNA:	107525239(MC2R)

DRO:	112322556(MC2R)

AJM:	119036774(MC2R)

PDIC:

114507058(MC2R)

PHAS:

123826281(MC2R)

MMF:	118619217(MC2R)

PPAM:

129081756(MC2R)

HAI:	109378038(MC2R)

RFQ:	117011863(MC2R)

PALE:

102898827(MC2R)

PGIG:

120583336(MC2R)

PVP:	105306370(MC2R)

RAY:	107507845(MC2R)

MJV:	108397606(MC2R)

TOD:	119243837(MC2R)

SARA:

101541299(MC2R)

SFUM:

130036122(MC2R)

SETR:

126004475(MC2R)

LAV:	100667193(MC2R)

TMU:

101345427

ETF:	101646149(MC2R)

DNM:	101444637(MC2R)

MDO:	100018891(MC2R)

GAS:	123231775(MC2R)

SHR:	100915134(MC2R)

AFZ:

127544055

PCW:	110207811(MC2R)

TVP:	118840180(MC2R)

PBRV:

138170014(MC2R)

MLAO:

141500762(MC2R)

OAA:	100076508(MC2R)

TACU:

119928746(MC2R)

GGA:	428516(MC2R)

PCOC:

116226229(MC2R)

MGP:	100543512(MC2R)

CJO:	107309913(MC2R)

TPAI:

128091133(MC2R)

LMUT:

125691061(MC2R)

NMEL:

110394758(MC2R)

APLA:

101799179(MC2R)

AACU:

137850897(MC2R)

OJA:	118162828(MC2R)

ACYG:

106034992(MC2R)

CATA:

118257402(MC2R)

AFUL:

116486456(MC2R)

TGU:	100226074(MC2R)

LSR:	110469250(MC2R)

VMC:	128811913(MC2R)

SCAN:

103815855(MC2R)

PMOA:

120500848(MC2R)

OTC:	121333217(MC2R)

PRUF:

121359056(MC2R)

ATRC:

139600657(MC2R)

MATE:

118701939(MC2R)

GFR:	102043133(MC2R)

FAB:	101808205(MC2R)

OMA:	130249900(MC2R)

PHI:	102112468(MC2R)

PMAJ:

107215252(MC2R)

CCAE:

111925026(MC2R)

CCW:	104687257(MC2R)

CBRC:

103612437(MC2R)

ACOE:

138104959(MC2R)

ETL:	114058227(MC2R)

ZAB:	102069634(MC2R)

ZLE:	135443264(MC2R)

ACHL:

103798605(MC2R)

SVG:	106849948(MC2R)

MMEA:

130585169(MC2R)

HRT:	120755549(MC2R)

SATI:

136369279(MC2R)

CFAI:

136289850(MC2R)

CCIC:

134048821(MC2R)

FPG:	101917528(MC2R)

FCH:	102047997(MC2R)

CCRI:

104163209(MC2R)

NNT:	104403636(MC2R)

SHAB:

115609381(MC2R)

ACUN:

113476827(MC2R)

ANOC:

141956900(MC2R)

SURA:

141954114(MC2R)

TALA:

104362946(MC2R)

ACHC:

115340462(MC2R)

HALD:

104317601(MC2R)

HLE:	104841558(MC2R)

AGEN:

126051367

HHAR:

128141936(MC2R)

BBUT:

142028921(MC2R)

GCL:

127013499

CSTI:

104553049(MC2R)

LDI:	104346732(MC2R)

MNB:	103768063(MC2R)

DPUB:

104308719(MC2R)

PPUS:

135179037(MC2R)

AVIT:

104270590(MC2R)

BRHI:

104494950(MC2R)

EGZ:	104132876(MC2R)

NNI:	104017650(MC2R)

PCRI:

104037285(MC2R)

PCAO:

104050430(MC2R)

PARX:

142053935(MC2R)

PADL:

103912328(MC2R)

AFOR:

103902960(MC2R)

FGA:	104078511(MC2R)

CBOR:

142078213(MC2R)

GSTE:

104254228(MC2R)

CBOY:

140646950(MC2R)

MAME:

142406743(MC2R)

CLV:	102088391(MC2R)

CNIC:

135985711(MC2R)

MUI:	104542512(MC2R)

PGUU:

104465641(MC2R)

PLET:

104615702(MC2R)

EHS:	104507870(MC2R)

CMAC:

104477747(MC2R)

CUCA:

104065538(MC2R)

TEO:	104384299(MC2R)

BREG:

104639410(MC2R)

GAME:

129203584(MC2R)

OHA:	104333435(MC2R)

ACAR:

104521146(MC2R)

CPEA:

104386943(MC2R)

CVF:	104290034(MC2R)

RTD:	128905876(MC2R)

CRID:

134510744(MC2R)

LMIC:

141738401(MC2R)

NARQ:

141463910(MC2R)

AAM:	106482807(MC2R)

AROW:

112973034(MC2R)

NPD:	112948227(MC2R)

TGT:	104565829(MC2R)

DNE:	112979850(MC2R)

SCAM:

104151287(MC2R)

ASN:	102369299(MC2R)

AMJ:	102568636(MC2R)

CPOO:

109317003(MC2R)

GGN:	109302874(MC2R)

PSS:	102457147(MC2R)

CIZ:	142008616(MC2R)

CMY:	102931474(MC2R)

CCAY:

125630975(MC2R)

LKP:	140905939(MC2R)

NDS:	141981466(MC2R)

DCC:	119851693(MC2R)

CPIC:

101942963(MC2R)

TST:	117873318(MC2R)

CABI:

116831762(MC2R)

MRV:	120399653(MC2R)

ACS:	100558671(mc2r)

ASAO:

132772808(MC2R)

PVT:	110078045(MC2R)

SUND:

121929632(MC2R)

PBI:	103053753(MC2R)

PMUR:

107290084(MC2R)

CTIG:

120306298(MC2R)

TSR:	106544171(MC2R)

PGUT:

117672608(MC2R)

PCAE:

139315907(MC2R)

APRI:

131195493(MC2R)

PTEX:

113435639(MC2R)

NSS:	113414812(MC2R)

VKO:	123021626(MC2R)

PMUA:

114600071(MC2R) 114600072

PRAF:

128416890(MC2R)

ZVI:	118090304(MC2R)

HCG:	128324157(MC2R)

GJA:	107119709(MC2R)

STOW:

125439425(MC2R)

EMC:	129333750(MC2R)

XLA:	108718761(mc2r.L)

XTR:	100491330(mc2r)

NPR:	108798784(MC2R)

RTEM:

120939645(MC2R)

ACAT:

141145923(MC2R)

PADS:

140331994(MC2R)

BBUF:

121002459(MC2R)

BGAR:

122939365(MC2R)

DTC:	141101164(MC2R)

PWL:	138276322(MC2R)

MUO:	115460320(MC2R)

GSH:	117355736(MC2R)

DRE:	353152(mc2r)

SRX:	107723103 107741732

SANH:

107672129 107704892

SGH:	107587907 107598023

CCAR:

109110841(mc2r)

CAUA:

113116822

CGIB:

127974367

PTET:

122360086(mc2r)

LROH:

127178874(mc2r)

GRF:	141343391(mc2r)

OMC:	131522091(mc2r)

PPRM:

120484744(mc2r)

RKG:	130097199(mc2r)

MAMB:

125243927(mc2r)

CIDE:

127497886

CERY:

137034273(mc2r)

MASI:

127452804

TROS:

130558336(mc2r)

TDW:	130432675(mc2r)

MANU:

129448466(mc2r)

PDAB:

135788832(mc2r)

IPU:	108267950(mc2r)

IFU:	128624351(mc2r)

PHYP:

113534149

SMEO:

124384857(mc2r)

TFD:	113644143(mc2r)

TVC:	132845905(mc2r)

CGAR:

128520785(mc2r)

NGRA:

132886030(mc2r)

TRN:	134310785(mc2r)

AMEX:

103035428(mc2r)

CMAO:

118813075(mc2r)

EEE:

113571201

CHAR:

105894061(mc2r)

SPIL:

134083349(mc2r)

ASAD:

121720880(mc2r)

TRU:	445998(mc2r)

TFS:

130533080

LCO:

104932571

NCC:

104963813

TBEN:

117497406(mc2r)

CGOB:

115021439(mc2r)

PGEO:

117460269(mc2r)

GACU:

117546025(mc2r)

EMAC:

134862217(mc2r)

ELY:	117266452(mc2r)

EFO:	125893611(mc2r)

PLEP:

121946006(mc2r)

SLUC:

116035428(mc2r)

ECRA:

117946051(mc2r)

ESP:	116686437(mc2r)

PFLV:

114557706(mc2r)

GAT:	120810971(mc2r)

PPUG:

119197912(mc2r)

AFB:	129109806(mc2r)

CLUM:

117727942(mc2r)

PSWI:

130205888(mc2r)

CANA:

137781207(mc2r)

CVE:	137891297(mc2r)

MSAM:

119898101(mc2r)

SCHU:

122881582(mc2r)

EARM:

139290379(mc2r)

CUD:	121514228(mc2r)

SPUL:

138583984(mc2r)

LMIX:

132983104(mc2r)

HTC:	141801020(mc2r)

ALAT:

119006126(mc2r)

ASTR:

137601464(mc2r)

PKLU:

139205178(mc2r)

MZE:

101487775

ONL:

100693550

OLA:

101173003

OML:	112141253(mc2r)

CSAI:

133440870(mc2r)

XMA:

XCO:

XHE:

PRET:

PFOR:

103136966(mc2r)

PLAI:

106954234

PMEI:

106925903

GAF:	122831058(mc2r)

PPRL:

129367441(mc2r)

CVG:

107102986

CTUL:

119797262(mc2r)

GMU:	124866204(mc2r)

NFU:

107378818

KMR:	108251293(mc2r)

ALIM:

106519252

NWH:	119410270(mc2r)

AOCE:

111589063(mc2r)

EJA:	138193838(mc2r)

BFRE:

138614980(mc2r)

MCEP:

125016670(mc2r)

CSEM:

103388887(mc2r)

POV:	109632125(mc2r)

SSEN:

122775157(mc2r)

SSOE:

131471720(mc2r)

HHIP:

117776469 117776875(mc2r)

HSP:	118113933(mc2r)

PPLT:

128449725(mc2r)

SMAU:

118313644(mc2r)

LCF:

108876285

SDU:	111227784(mc2r)

SLAL:

111664132(mc2r)

XGL:	120784278(mc2r)

HCQ:	109521865(mc2r)

SSCV:

125975286(mc2r)

SBIA:

133500991(mc2r)

PEE:	133401132(mc2r)

PTAO:

133479540(mc2r)

BPEC:

110171420

ENY:	140373432(mc2r)

MALB:

109963853(mc2r)

BSPL:

114843173(mc2r)

SJO:	128366084(mc2r)

SSCO:

133983281(mc2r)

TTY:	137191940(mc2r)

GMH:	115554723(mc2r)

SASA:

106592485

STRU:

115183953 115183963

OTW:	112240494(mc2r)

OMY:	100136719(mc2r)

OGO:	124021422 124021837

ONE:

115126575

OKI:

116359316

OKE:	118383552(mc2r)

OMM:	135521062 135521382

OCLA:

139394154 139394161 139405606

SALP:

112076736

SFON:

129837838 129842499

CCLU:

121585412(mc2r)

ELS:	105016486(mc2r)

OEP:	134022960(mc2r)

SFM:	108940538(mc2r)

PKI:	111843705(mc2r)

AANG:

118209499(mc2r)

AROT:

135241918(mc2r)

CCOG:

133137623(mc2r)

LOC:	102692633(mc2r)

PSPA:

121308351(mc2r)

ARUT:

117400761(mc2r)

PSEX:

120516720(mc2r)

LPIC:

129271279 129274282 129274857 129277169

LVG:	121411852 121424412 121424490 121424596 121426012 121426013 121426014 121426480

BCOO:

BAFF:

BPAS:

HRF:

CVN:	111117628 111122349

RPHI:

132729375

LAK:

106152454

NVE:

116616773

EPA:	110235965 110239876 110240150 110242330

ATEN:

116288548 116290359 116290361 116294934 116294979 116296754 116299315 116303596 116304450 116307194

AMIL:

114963487

MCAZ:

138018643 138019202 138021487 138021708 138021823 138022022 138022114 138022148 138028575 138044752 138055898 138055899 138055900 138055904 138055905

PDAM:

113666480 113673400 113682527

XEN:	124441667 124452504

» show all

Reference

PMID:1325670

Authors

Mountjoy KG, Robbins LS, Mortrud MT, Cone RD

Title

The cloning of a family of genes that encode the melanocortin receptors.

Journal

Science 257:1248-51 (1992)
DOI:10.1126/science.1325670

Sequence

[hsa:4158]

LinkDB

DBGET integrated database retrieval system