KEGG ORTHOLOGY: K04346

ORTHOLOGY: K04346

Entry

K04346                      KO

Symbol

GNA12

Name

guanine nucleotide-binding protein subunit alpha-12

Pathway

map04010

MAPK signaling pathway

map04022

cGMP-PKG signaling pathway

map04071

Sphingolipid signaling pathway

map04072

Phospholipase D signaling pathway

map04270

Vascular smooth muscle contraction

map04361

Axon regeneration

map04730

Long-term depression

map04810

Regulation of actin cytoskeleton

map04928

Parathyroid hormone synthesis, secretion and action

map05130

Pathogenic Escherichia coli infection

map05163

Human cytomegalovirus infection

map05200

Pathways in cancer

Disease

H02434

Diffuse large B-cell lymphoma, not otherwise specified

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04072 Phospholipase D signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04071 Sphingolipid signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04022 cGMP-PKG signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09156 Nervous system
   04730 Long-term depression
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09158 Development and regeneration
   04361 Axon regeneration
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04031 GTP-binding proteins
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of hepatic cells
   K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
GTP-binding proteins [BR:ko04031]
Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12

Genes

HSA:	2768(GNA12)

PTR:	463234(GNA12)

PPS:	100979605(GNA12)

GGO:	101147243(GNA12)

PPYG:

129040269(GNA12)

NLE:	100591916(GNA12)

HMH:	116810819(GNA12)

SSYN:

129489505(GNA12)

MCC:	100429106(GNA12)

MCF:	101867258(GNA12)

MTHB:

126951492

MNI:	105483392(GNA12)

CSAB:

103246857(GNA12)

CATY:

105571739(GNA12)

PANU:

101015317(GNA12)

TGE:	112620279(GNA12)

MLEU:

105537343(GNA12)

RRO:	104664964(GNA12)

RBB:	108543875(GNA12)

TFN:	117073210(GNA12)

PTEH:

111523703(GNA12)

CANG:

105522441(GNA12) 105522480

CJC:	100387912(GNA12)

SBQ:	101042405(GNA12)

CIMI:

108308110(GNA12)

ANAN:

105719502(GNA12)

CSYR:

103254023(GNA12)

MMUR:

105868406(GNA12)

LCAT:

123631510(GNA12)

PCOQ:

105806081(GNA12)

OGA:	100956403(GNA12)

MMU:	14673(Gna12)

MCAL:

110295092(Gna12)

MPAH:

110312844(Gna12)

RNO:	81663(Gna12)

MCOC:

116068678(Gna12)

ANU:	117698098(Gna12)

MUN:	110554732(Gna12)

CGE:	100760944(Gna12)

MAUA:

101824460(Gna12)

PROB:

127237273(Gna12)

PLEU:

114705518(Gna12)

MORG:

121445951 121464859

MFOT:

126514346

AAMP:

119825531(Gna12)

NGI:	103748670(Gna12)

HGL:	101697421(Gna12)

CPOC:

100726202(Gna12)

CCAN:

109683409(Gna12)

DORD:

105990866(Gna12)

DSP:	122113573(Gna12)

PLOP:

125339093(Gna12)

NCAR:

124970276

MMMA:

107155972

OCU:

100347293

OPI:	101525794(GNA12)

TUP:	102501406(GNA12)

GVR:	103585712(GNA12)

CFA:	102154318(GNA12)

CLUD:

112640210(GNA12)

VVP:	112929357(GNA12)

VLG:	121487216(GNA12)

NPO:	129519699(GNA12)

AML:	100465369(GNA12)

UMR:	103669942(GNA12)

UAH:	113267979(GNA12)

UAR:	123802492(GNA12)

ELK:

111146098

LLV:

125090604

MPUF:

101677577(GNA12)

MNP:	132026441(GNA12)

MLK:	131819299(GNA12)

NVS:	122896083(GNA12)

ORO:	101371250(GNA12)

EJU:	114199958(GNA12)

ZCA:	113933210(GNA12)

MLX:	117999301(GNA12)

NSU:	110571937(GNA12)

LWW:	102735043(GNA12)

FCA:	101093316(GNA12)

PYU:	121017425(GNA12)

PBG:	122471226(GNA12)

PVIV:

125154113(GNA12)

LRUF:

124519214

PTG:	102961052(GNA12)

PPAD:

109251142(GNA12)

PUC:

125928430

AJU:

106984497

HHV:	120228022(GNA12)

BTA:	515159(GNA12)

BOM:	102265273(GNA12)

BIU:	109578204(GNA12)

BBUB:

102409709(GNA12)

BBIS:

105002254(GNA12)

CHX:	102185175(GNA12)

OAS:	101111070(GNA12)

BTAX:

128064366(GNA12)

ODA:	120882944(GNA12)

CCAD:

122432743(GNA12)

MBEZ:

129545783(GNA12)

SSC:	100525156(GNA12)

CFR:	102524525(GNA12) 116666290

CBAI:

105067606 105078210(GNA12)

CDK:	105086681(GNA12)

VPC:	102536014(GNA12)

BACU:

103009974(GNA12)

BMUS:

118880853(GNA12)

LVE:	103069136(GNA12)

OOR:	101281075(GNA12)

DLE:	111169388(GNA12)

PSIU:

116739840(GNA12)

NASI:

112412027(GNA12)

ECB:	100060005(GNA12)

EPZ:	103549418(GNA12)

EAI:	106834780(GNA12)

MYB:	102260289(GNA12)

MYD:	102763801(GNA12)

MMYO:

118657873(GNA12)

MDT:	132236042(GNA12)

PKL:	118711380(GNA12)

EFUS:

103299196(GNA12)

MNA:	107541162(GNA12)

DRO:	112319524(GNA12)

SHON:

118995031(GNA12)

AJM:	119037188 119043796(GNA12)

PDIC:

114509149(GNA12)

PHAS:

123809602(GNA12)

MMF:	118616426(GNA12)

PPAM:

129069895(GNA12)

HAI:	109380223(GNA12)

RFQ:	117016789(GNA12)

PALE:

102891706(GNA12)

PGIG:

120615752(GNA12)

PVP:	105294560(GNA12)

RAY:	107521430(GNA12)

MJV:	108383439(GNA12)

TOD:	119241629(GNA12)

SARA:

101539799(GNA12)

SETR:

126030440(GNA12)

LAV:	100676444(GNA12)

TMU:

101351796

ETF:	101637962(GNA12)

DNM:	101425884(GNA12)

MDO:	100010453(GNA12)

GAS:	123233988(GNA12)

SHR:	100916443(GNA12)

AFZ:

127563717

PCW:	110200100(GNA12)

TVP:	118855030(GNA12)

OAA:	100082592(GNA12)

GGA:	769924(GNA12)

PCOC:

116237643(GNA12)

MGP:	100550659(GNA12)

CJO:	107320696(GNA12)

TPAI:

128078993(GNA12)

LMUT:

125700551(GNA12)

NMEL:

110405782(GNA12)

APLA:

101798445(GNA12)

ACYG:

106032065(GNA12)

CATA:

118249105(GNA12)

AFUL:

116495096(GNA12)

TGU:	100225137(GNA12)

LSR:	110480984(GNA12)

SCAN:

103817628(GNA12)

PMOA:

120513017(GNA12)

OTC:	121334382(GNA12)

PRUF:

121350703(GNA12)

GFR:	102044790(GNA12)

FAB:	101818259(GNA12)

OMA:	130259123(GNA12)

PHI:	102104762(GNA12)

PMAJ:

107211274(GNA12)

CCAE:

111936095(GNA12)

CCW:	104684810(GNA12)

CBRC:

103615421(GNA12)

ETL:	114060163(GNA12)

ZAB:	102061493(GNA12)

ZLE:	135453945(GNA12)

ACHL:

103805475(GNA12)

SVG:	106849684(GNA12)

MMEA:

130575727(GNA12)

HRT:	120759457(GNA12)

SATI:

136367913(GNA12)

FPG:	101917262(GNA12)

FCH:	102059010(GNA12)

CCRI:

104161739(GNA12)

NNT:	104404855(GNA12)

SHAB:

115607349(GNA12)

ACUN:

113485647(GNA12)

TALA:

104365124(GNA12)

ACHC:

115335761(GNA12)

HALD:

104321090(GNA12)

HLE:	104833566(GNA12)

AGEN:

126034026

GCL:

127022239

CSTI:

104556093(GNA12)

LDI:	104348690(GNA12)

MNB:	103776247(GNA12)

DPUB:

104297114(GNA12)

AVIT:

104269513(GNA12)

BRHI:

104491840(GNA12)

EGZ:	104132621(GNA12)

NNI:	104015218(GNA12)

PCRI:

104037638(GNA12)

PCAO:

104043924(GNA12)

PADL:

103913532(GNA12)

AFOR:

103904872(GNA12)

FGA:	104071699(GNA12)

GSTE:

104265046(GNA12)

CLV:	102088372(GNA12)

MUI:	104538606(GNA12)

PGUU:

104470588(GNA12)

PLET:

104623881(GNA12)

EHS:	104516171(GNA12)

CMAC:

104475831(GNA12)

CUCA:

104059213(GNA12)

TEO:	104371953(GNA12)

BREG:

104642082(GNA12)

OHA:	104331208(GNA12)

ACAR:

104531429(GNA12)

CPEA:

104385246(GNA12)

CVF:	104287699(GNA12)

RTD:	128913572(GNA12)

AAM:	106483939(GNA12)

AROW:

112974274(GNA12)

NPD:	112960066(GNA12)

TGT:	104571605(GNA12)

DNE:	112992860(GNA12)

SCAM:

104153963(GNA12)

ASN:	102377286(GNA12)

AMJ:	102559993(GNA12)

CPOO:

109314716(GNA12)

GGN:	109294314(GNA12)

PSS:	102445616(GNA12)

CMY:	102931254(GNA12)

CCAY:

125643747(GNA12)

DCC:	119862577(GNA12)

CPIC:

101947834(GNA12)

TST:	117884213(GNA12)

CABI:

116816726(GNA12)

MRV:	120373445(GNA12)

ACS:	100564021(gna12)

ASAO:

132782165(GNA12)

PVT:	110083721(GNA12)

SUND:

121914259(GNA12)

PBI:	103050241(GNA12)

PMUR:

107290610(GNA12)

CTIG:

120315644(GNA12)

TSR:	106543761(GNA12)

PGUT:

117659919(GNA12)

APRI:

131185123(GNA12)

PTEX:

113438808(GNA12)

NSS:	113423705(GNA12)

VKO:	123025206(GNA12)

PMUA:

114584033(GNA12)

PRAF:

128401334(GNA12)

ZVI:	118092639(GNA12)

HCG:	128336449(GNA12)

GJA:	107116703(GNA12)

STOW:

125431108(GNA12)

EMC:	129338685(GNA12)

MUO:	115476043(GNA12)

GSH:	117369354(GNA12)

DRE:	503589(gna12a)

SRX:	107753491 107758336

SANH:

107674729 107703403

SGH:	107581709(gna12) 107592501

CCAR:

109088191 109113757

CAUA:

113050125 113079568 113088985 113092116

CGIB:

127952148 127953545

PTET:

122341311(gna12a)

LROH:

127160470(gna12a)

OMC:	131537052(gna12a)

PPRM:

120489108(gna12a)

RKG:	130095021(gna12a)

MAMB:

125269719(gna12a)

CIDE:

127509296

CERY:

137017790(gna12a)

MASI:

127443584 127443861 127445556 127450194 127452347

TROS:

130561712(gna12a)

TDW:	130425677(gna12a)

MANU:

129432518(gna12a) 129444883 129444884 129444885

IPU:	108257129(gna12a)

IFU:	128600128(gna12a)

PHYP:

113536042(gna12)

SMEO:

124375972(gna12a)

TFD:	113660383(gna12a)

TVC:	132863941(gna12a)

TRN:	134306869(gna12a)

AMEX:

103024018(gna12a)

CMAO:

118805729(gna12a)

EEE:	113581016(gna12)

CHAR:

105890330 105890719(gna12a)

TRU:	101078184(gna12)

TFS:	130528018(gna12a)

TNG:	GSTEN00015763G001

LCO:	104929956(gna12)

NCC:	104953227(gna12)

TBEN:

117481651(gna12a)

CGOB:

115008038(gna12)

PGEO:

117448073(gna12a)

GACU:

117556119(gna12a)

EMAC:

134865114(gna12a)

ELY:	117255443(gna12a)

EFO:	125885556(gna12a)

PLEP:

121941718(gna12a)

SLUC:

116042660(gna12a)

ECRA:

117957719(gna12a)

ESP:	116705828(gna12)

PFLV:

114568096(gna12)

GAT:	120825079(gna12a)

PPUG:

119217467(gna12a)

AFB:	129095527(gna12a)

CLUM:

117737754(gna12a)

PSWI:

130189521(gna12a)

MSAM:

119898751(gna12a) 119898752

SCHU:

122874052(gna12a)

CUD:	121508158(gna12a)

ALAT:

119019371(gna12a)

MZE:	101473086(gna12)

ONL:	100695956(gna12)

OAU:	116312366(gna12a)

OLA:	101166935(gna12)

OML:	112137476(gna12a)

CSAI:

133441845(gna12a)

XMA:	102222306(gna12)

XCO:	114145506(gna12)

XHE:	116720292(gna12)

PRET:

103462653(gna12)

PFOR:

107834460

GAF:	122829843(gna12a)

PPRL:

129353743(gna12a)

CVG:	107086421(gna12)

CTUL:

119783694(gna12a)

GMU:	124868741(gna12a)

NFU:	107388805(gna12)

KMR:	108231102(gna12a)

ALIM:

106519647(gna12) 106535814

NWH:	119422367(gna12a)

AOCE:

111579495(gna12)

MCEP:

125004095(gna12a)

CSEM:

103383240(gna12)

POV:	109639272(gna12)

SSEN:

122771451(gna12a)

HHIP:

117767462(gna12a)

HSP:	118123197(gna12a)

PPLT:

128435359(gna12a)

SMAU:

118312928(gna12a)

LCF:	108888452(gna12a)

SDU:	111216573(gna12)

SLAL:

111663289(gna12)

XGL:	120800111(gna12a)

HCQ:	109511425(gna12)

SSCV:

125969295

SBIA:

133506237(gna12a)

PEE:	133403577(gna12a)

PTAO:

133477245(gna12a)

BPEC:

110153513(gna12)

MALB:

109968205(gna12)

BSPL:

114858608(gna12a)

SJO:	128380053(gna12a)

SASA:

106593532

STRU:

115177669 115181662

OTW:

112239603

OMY:	110513250 110519706(gna12a)

OGO:	124003139(gna12a) 124024495 124029096

OKI:	109885709(gna12)

OKE:

127921912

SNH:	120035391(gna12a)

CCLU:

121534255(gna12a)

ELS:	105006302(gna12)

SFM:	108927048(gna12)

PKI:	111845481 111853263

AANG:

118217277(gna12a) 118221254

LOC:	102693638(gna12)

PSPA:

121300879 121331272

ARUT:

117418024 117431230

PSEX:

120541896(gna12a)

LCM:	102367557(GNA12)

CMK:	103185131(gna12a)

RTP:	109917843(gna12a) 109931104

CPLA:

122542251 122560793(gna12a)

HOC:	132825238(gna12a) 132831524

LERI:

129706639(gna12a)

SPU:

414055

AJC:

117122316

SKO:

100371005

DME:	Dmel_CG17678(cta)

DER:

6548622

DSE:

6620479

DSI:	Dsimw501_GD17672(Dsim_GD17672)

DYA:	Dyak_GE22695(Dyak_cta)

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10235

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

109429571 115262082 115262090

ASUA:

134213687

CQU:	CpipJ_CPIJ001150

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105675078(cta)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:	124410307 124412685

NPT:	124220614 124221057

NFB:	124181951 124185784

NLO:	107221508 107224562

NVG:	124306360 124308049

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:	108559178 108565189

APLN:

108732666

PPYR:

116175451

OTU:

111420380

BMOR:

100862775(Galpha12)

BMAN:

114248860

MSEX:

115443118

DPL:	KGM_209650

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106681511(cta)

NLU:

111051510

HVI:

124367594

MQU:

128991671

PHU:	Phum_PHUM222390

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_190301(Gna12)

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

DSV:

RSAN:

RMP:

TUT:

CSCU:

CVS:	136984147 136989625(cta)

PTEP:

107444621 107449780

ABRU:

129969629 129984273

UDV:	129225762 129227764

SDM:	118181202 118186749

CEL:	CELE_F18G5.3(gpa-12)

CBR:	CBG_16182(Cbr-gpa-12)

CRQ:	GCK72_023268

NAI:	NECAME_09853

BMY:	BM_BM3442(Bma-gpa-12)

LOA:	LOAG_11957

TSP:

Tsp_00479

HRO:	HELRODRAFT_110990 HELRODRAFT_96238

LGI:	LOTGIDRAFT_137888

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

RPHI:

DPOL:

MAEA:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:	124447715 124448767

HMG:

100192290

HSY:

130648869

TAD:	TRIADDRAFT_49927

» show all

Reference

PMID:8423800

Authors

Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA

Title

Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.

Journal

Mol Cell Biol 13:762-8 (1993)
DOI:10.1128/MCB.13.2.762

Sequence

[hsa:2768]

Reference

PMID:22609986

Authors

Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D

Title

PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.

Journal

Nat Cell Biol 14:686-96 (2012)
DOI:10.1038/ncb2507

Sequence

[hsa:2768]

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