KEGG ORTHOLOGY: K04394

ORTHOLOGY: K04394

Entry

K04394                      KO

Symbol

CASP4, CASP11

Name

caspase 4 [EC:3.4.22.57 3.4.22.64]

Pathway

map04613

Neutrophil extracellular trap formation

map04621

NOD-like receptor signaling pathway

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K04394  CASP4, CASP11; caspase 4
   04621 NOD-like receptor signaling pathway
    K04394  CASP4, CASP11; caspase 4
09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04394  CASP4, CASP11; caspase 4
   05132 Salmonella infection
    K04394  CASP4, CASP11; caspase 4
   05131 Shigellosis
    K04394  CASP4, CASP11; caspase 4
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04394  CASP4, CASP11; caspase 4
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.57  caspase-4
     K04394  CASP4, CASP11; caspase 4
    3.4.22.64  caspase-11
     K04394  CASP4, CASP11; caspase 4
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C14: caspase family
   K04394  CASP4, CASP11; caspase 4

Genes

HSA:	837(CASP4)

PTR:	451518(CASP4)

PPS:	100991353(CASP4)

GGO:	101139012 101139367

PON:	100436933(CASP4)

PPYG:

129007265(CASP4)

NLE:	100587427(CASP4)

HMH:

116476873

SSYN:

129479583

MCC:	704864(CASP4)

MCF:

102116921

MTHB:

126936246

MNI:

105493691

CSAB:

103248367(CASP4)

CATY:

105588758(CASP4)

PANU:

101005674

TGE:

112605779

MLEU:

105534144

RRO:	104665269(CASP4)

RBB:

108513171

TFN:

117080360

PTEH:

111540081

CANG:

105500954(CASP4)

CJC:

SBQ:

CIMI:

ANAN:

CSYR:

MMUR:

LCAT:

PCOQ:

105822166 105822168(CASP5)

OGA:	100953733 105888133(CASP4)

MMU:	12363(Casp4)

MCAL:

110301962

MPAH:

110328019(Casp4)

RNO:	114555(Casp4)

MCOC:

116072580(Casp4)

ANU:	117699797(Casp4)

NGI:	103743234(Casp4)

HGL:	101700797(Casp4)

CPOC:

100731032

CCAN:

109694936

DORD:

105980799(Casp5)

PLOP:

NCAR:

MMMA:

ITI:

OCU:

OPI:	101530447 101530693

TUP:	102468460 102489894(CASP4)

GVR:

103595948

CFA:	403724(CASP4)

CLUD:

112671423(CASP4)

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:	102743984(CASP4)

FCA:	493961(CASP4)

PYU:	121020795(CASP4)

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:

BTA:	338039(CASP4)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

CSUM:

ODA:

CCAD:

OVR:

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

DLE:

PCAD:

PSIU:

116757817(CASP4)

NASI:

112415742

ECB:	100069303(CASP4) 100069322

EPZ:	103559837 103559840

EAI:	106837655(CASP4) 106837665

MYB:	102257847 102260720 106726136 106726185

MYD:

102769995

MMYO:

118664119 118664385 118664387

MLF:	102423287 102430359 102430672 102430997

MDT:	132240572 132241718

MYUM:

139017503(CASP4) 139018298

PKL:	118712751 118713780

EFUS:

103299257 103303785 114227918

MNA:

107532382

DRO:	112314268 112314306 112314322

SHON:

118988282

AJM:	119060734 119060770 119060787

PDIC:

114498810 114499617(CASP4) 114499889

PHAS:

123818755 123819792 123819902

MMF:	118627675 118628466 118628467

PPAM:

129086065 129086111

HAI:	109377696 109377700

RFQ:	117029841 117030503

PALE:

102887403 102895641

PGIG:

120599660 120599679

PVP:	105297443 105297474

RAY:

107504289

MJV:	108385984(CASP1) 118966797

TOD:	119242137 119242138 119242139

SARA:

105942813

SETR:

126016054 126016453

LAV:

100661933

TMU:	101352905 101353422 101353932

ETF:

101653056

DNM:	101418845(CASP4) 101425305

MDO:

100032600

GAS:

123239006

SHR:	100914126 100914382

AFZ:	127554936 127554937 127554939 127554940

PCW:	110215002 110215005

TVP:	118839465 118840382(CASP4)

PBRV:

PWL:

PRET:

LCF:

ARUT:

CCRN:

Reference

PMID:16465268

Authors

Kamada S, Funahashi Y, Tsujimoto Y

Title

Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.

Journal

Cell Death Differ 4:473-8 (1997)
DOI:10.1038/sj.cdd.4400268

Reference

PMID:7797592

Authors

Munday NA, Vaillancourt JP, Ali A, Casano FJ, Miller DK, Molineaux SM, Yamin TT, Yu VL, Nicholson DW

Title

Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases.

Journal

J Biol Chem 270:15870-6 (1995)
DOI:10.1074/jbc.270.26.15870

Sequence

[hsa:837]

Reference

PMID:9491891

Authors

Wang S, Miura M, Jung YK, Zhu H, Li E, Yuan J

Title

Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

Journal

Cell 92:501-9 (1998)
DOI:10.1016/S0092-8674(00)80943-5

Sequence

[mmu:12363]

Reference

PMID:8702803

Authors

Wang S, Miura M, Jung Yk, Zhu H, Gagliardini V, Shi L, Greenberg AH, Yuan J

Title

Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE.

Journal

J Biol Chem 271:20580-7 (1996)
DOI:10.1074/jbc.271.34.20580

Sequence

[mmu:12363]

LinkDB

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