KEGG ORTHOLOGY: K04406

ORTHOLOGY: K04406

Entry

K04406                      KO

Symbol

MAP4K3, GLK

Name

mitogen-activated protein kinase kinase kinase kinase 3 [EC:2.7.11.1]

Pathway

map04010

MAPK signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04406  MAP4K3, GLK; mitogen-activated protein kinase kinase kinase kinase 3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04406  MAP4K3, GLK; mitogen-activated protein kinase kinase kinase kinase 3
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04406  MAP4K3, GLK; mitogen-activated protein kinase kinase kinase kinase 3
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE20 family
   K04406  MAP4K3, GLK; mitogen-activated protein kinase kinase kinase kinase 3

Genes

HSA:	8491(MAP4K3)

PTR:	459173(MAP4K3)

PPS:	100971346(MAP4K3)

GGO:	101137521(MAP4K3)

PON:	100174288(MAP4K3)

PPYG:

129030293(MAP4K3)

NLE:	100591188(MAP4K3)

HMH:	116483681(MAP4K3)

SSYN:

129462750(MAP4K3)

MCC:	713952(MAP4K3)

MCF:	102130367(MAP4K3)

MTHB:

126933540

MNI:	105464888(MAP4K3)

CSAB:

103220435(MAP4K3)

CATY:

105597211(MAP4K3)

PANU:

101023675(MAP4K3)

TGE:	112605048(MAP4K3)

MLEU:

105532624(MAP4K3)

RRO:	104663029(MAP4K3)

RBB:	108542782(MAP4K3)

TFN:	117062421(MAP4K3)

PTEH:

111545352(MAP4K3)

CANG:

105507444(MAP4K3)

CJC:	100413973(MAP4K3)

SBQ:	101043945(MAP4K3)

CIMI:

108307267(MAP4K3)

ANAN:

105716091(MAP4K3)

CSYR:

103275117(MAP4K3)

MMUR:

105884530(MAP4K3)

LCAT:

123636828(MAP4K3)

PCOQ:

105817992(MAP4K3)

OGA:	100957869(MAP4K3)

MMU:	225028(Map4k3)

MCAL:

110312508(Map4k3)

MPAH:

110335544(Map4k3)

RNO:	170920(Map4k3)

MCOC:

116079936(Map4k3)

ANU:	117716796(Map4k3)

ASYL:

127687644(Map4k3)

MUN:	110547067(Map4k3)

CGE:	100756760(Map4k3)

MAUA:

101823207(Map4k3)

PROB:

127214883(Map4k3)

PLEU:

114681623(Map4k3)

PMAV:

102904690(Map4k3)

MORG:

121432877(Map4k3)

MFOT:

126514527

AAMP:

119806389(Map4k3)

NGI:	103743942(Map4k3)

HGL:	101709571(Map4k3)

CPOC:

100716179(Map4k3)

CCAN:

109685240(Map4k3)

DORD:

105986871(Map4k3)

DSP:	122104521(Map4k3)

DMER:

138829218(Map4k3)

PLOP:

125356526(Map4k3)

NCAR:

124963665

MMMA:

107137014(Map4k3)

ITI:	101960092(Map4k3)

OCU:

100356354

OPI:	101532680(MAP4K3)

OCZ:	121164834(MAP4K3)

TUP:	102495445(MAP4K3)

GVR:

103606904

CFA:	475734(MAP4K3)

CLUD:

112664485(MAP4K3)

VVP:	112935311(MAP4K3)

VLG:	121491305(MAP4K3)

NPO:	129510759(MAP4K3)

AML:	100484030(MAP4K3)

UMR:	103671890(MAP4K3)

UAH:	113241667(MAP4K3)

UAR:	123799806(MAP4K3)

ELK:

111158411

LLV:

125108251

MPUF:

101682830(MAP4K3)

MNP:	132021313(MAP4K3)

MLK:	131840495(MAP4K3)

NVS:	122915134(MAP4K3)

ORO:	101370836(MAP4K3)

EJU:	114219627(MAP4K3)

ZCA:	113937198(MAP4K3)

MLX:	118007798(MAP4K3)

NSU:	110587564(MAP4K3)

LWW:	102744073(MAP4K3)

FCA:	101098622(MAP4K3)

PYU:	121044369(MAP4K3)

PCOO:

112864131(MAP4K3)

PBG:	122497236(MAP4K3)

PVIV:

125161829(MAP4K3)

LRUF:

124503647

LGF:	123581209(MAP4K3)

AJU:

106988606

PTG:	102949110(MAP4K3)

PPAD:

109265462(MAP4K3)

PUC:

125937508

PLEZ:

122216390(MAP4K3)

HHV:	120244630(MAP4K3)

BTA:	507624(MAP4K3)

BOM:	102287518(MAP4K3)

BIU:	109566008(MAP4K3)

BBUB:

102394844(MAP4K3)

BBIS:

104999937(MAP4K3)

CHX:	102180678(MAP4K3)

OAS:	101118350(MAP4K3)

BTAX:

128056991(MAP4K3)

CSUM:

138083100(MAP4K3)

ODA:	120851698(MAP4K3)

CCAD:

122441596(MAP4K3)

MREE:

136164445(MAP4K3)

OVR:	110150696(MAP4K3)

MBEZ:

129539074(MAP4K3)

SSC:	100622259(MAP4K3)

CFR:	102520414(MAP4K3)

CBAI:

105079060(MAP4K3)

CDK:	105103663(MAP4K3)

VPC:	102542485(MAP4K3)

BACU:

102997823(MAP4K3)

BMUS:

118905621(MAP4K3)

LVE:	103078212(MAP4K3)

OOR:	101285653(MAP4K3)

LALB:

132531812(MAP4K3)

GMF:	115854094(MAP4K3)

DDP:	132434962(MAP4K3)

DLE:	111174847(MAP4K3)

PCAD:

102990600(MAP4K3)

PSIU:

116764281(MAP4K3)

PPHC:

136134084(MAP4K3)

NASI:

112405221(MAP4K3)

ECB:	100069835(MAP4K3)

EPZ:	103565573(MAP4K3)

EAI:	106825862(MAP4K3)

MYB:	102250714(MAP4K3)

MYD:	102756817(MAP4K3)

MMYO:

118669072(MAP4K3)

MLF:	102419659(MAP4K3)

MDT:	132213444(MAP4K3)

MYUM:

139019841(MAP4K3)

PKL:	118717265(MAP4K3)

EFUS:

103305449(MAP4K3)

MNA:	107541797(MAP4K3)

DRO:	112297970(MAP4K3)

SHON:

119001480(MAP4K3)

AJM:	119042887(MAP4K3)

PDIC:

114498649(MAP4K3)

PHAS:

123811389(MAP4K3)

MMF:	118630768(MAP4K3)

PPAM:

129066003(MAP4K3)

RFQ:	117032926(MAP4K3)

PALE:

102881794(MAP4K3)

PGIG:

120621745(MAP4K3)

PVP:	105292946(MAP4K3)

RAY:	107509599(MAP4K3)

MJV:	108406085(MAP4K3)

TOD:	119259375(MAP4K3)

SARA:

101538925(MAP4K3)

SFUM:

130038760(MAP4K3)

SETR:

126023904(MAP4K3)

LAV:	100657946(MAP4K3)

TMU:

101358891

ETF:	101644281(MAP4K3)

DNM:	101436324(MAP4K3)

MDO:	100010710(MAP4K3)

GAS:	123236830(MAP4K3)

SHR:	100932750(MAP4K3)

AFZ:

127548009

PCW:	110201377(MAP4K3)

TVP:	118841767(MAP4K3)

PBRV:

138176453

MLAO:

141500828(MAP4K3)

OAA:	100078832(MAP4K3)

TACU:

119941210(MAP4K3)

GGA:	425965(MAP4K3)

PCOC:

116231222(MAP4K3)

MGP:	100542781(MAP4K3)

CJO:	107310901(MAP4K3)

TPAI:

128086858(MAP4K3)

LMUT:

125688713(MAP4K3)

NMEL:

110395456(MAP4K3)

APLA:

101796883(MAP4K3)

ACYG:

106045605(MAP4K3)

CATA:

118251104(MAP4K3)

AFUL:

116487180(MAP4K3)

TGU:	100225187(MAP4K3)

LSR:	110474835(MAP4K3)

SCAN:

103821322(MAP4K3)

PMOA:

120506835(MAP4K3)

OTC:	121335763(MAP4K3)

PRUF:

121358563(MAP4K3)

ATRC:

139588408(MAP4K3)

GFR:	102035251(MAP4K3)

FAB:	101809312(MAP4K3)

OMA:	130250969(MAP4K3)

PHI:	102101839(MAP4K3)

PMAJ:

107201902(MAP4K3)

CCAE:

111926574(MAP4K3)

CCW:	104696642(MAP4K3)

CBRC:

103624993(MAP4K3)

ACOE:

138107667(MAP4K3)

ETL:	114060050(MAP4K3)

ZAB:	102068753(MAP4K3)

ZLE:	135445995(MAP4K3)

ACHL:

103806036(MAP4K3)

SVG:	106862254(MAP4K3)

MMEA:

130584903(MAP4K3)

HRT:	120749966(MAP4K3)

SATI:

136359767(MAP4K3)

CCIC:

134042795(MAP4K3)

FPG:	101923451(MAP4K3)

FCH:	102052252(MAP4K3)

CCRI:

104158417

NNT:	104410675(MAP4K3)

SHAB:

115609916(MAP4K3)

ACUN:

113478812(MAP4K3)

TALA:

104362836(MAP4K3)

ACHC:

115348854(MAP4K3)

HLE:	104828635(MAP4K3)

AGEN:

126046032

HHAR:

128139117(MAP4K3)

GCL:

127014090

CSTI:

104551072(MAP4K3)

LDI:	104344176(MAP4K3)

MNB:	103778600(MAP4K3)

DPUB:

104301072(MAP4K3)

PPUS:

135176839(MAP4K3)

AVIT:

104279690(MAP4K3)

BRHI:

104489425

NNI:	104022125(MAP4K3)

PCRI:

104037466(MAP4K3)

PCAO:

104046906

PADL:

103925077(MAP4K3)

AFOR:

103895255(MAP4K3)

FGA:

104069810

CBOR:

142081032(MAP4K3)

CBOY:

140649683(MAP4K3)

MAME:

142407341(MAP4K3)

CNIC:

135986571(MAP4K3)

PGUU:

104470702(MAP4K3)

PLET:

104620273(MAP4K3)

CUCA:

104055415(MAP4K3)

OHA:	104339480(MAP4K3)

ACAR:

104527932(MAP4K3)

CPEA:

104398425(MAP4K3)

CVF:	104293037(MAP4K3)

RTD:	128906544(MAP4K3)

CRID:

134512677(MAP4K3)

LMIC:

141740417(MAP4K3)

AAM:	106499683(MAP4K3)

AROW:

112973149(MAP4K3)

NPD:	112951360(MAP4K3)

DNE:	112989336(MAP4K3)

SCAM:

104151818(MAP4K3)

ASN:	102377105(MAP4K3)

AMJ:	102576662(MAP4K3)

CPOO:

109319469(MAP4K3)

GGN:	109296693(MAP4K3)

PSS:	102451087(MAP4K3)

CIZ:	142010814(MAP4K3)

CMY:	102941872(MAP4K3)

CCAY:

125633301(MAP4K3)

DCC:	119853925(MAP4K3)

CPIC:

101939419(MAP4K3)

TST:	117874156(MAP4K3)

CABI:

116831076(MAP4K3)

MRV:	120402382(MAP4K3)

ACS:	100559042(map4k3)

ASAO:

132761544(MAP4K3)

PVT:	110079550(MAP4K3)

SUND:

121924281(MAP4K3)

PBI:	103066545(MAP4K3)

PMUR:

107289229(MAP4K3)

CTIG:

120297827(MAP4K3)

TSR:	106548401(MAP4K3)

PGUT:

117671560(MAP4K3)

PCAE:

139308625(MAP4K3)

APRI:

131189160(MAP4K3)

PTEX:

113433384(MAP4K3)

NSS:	113423066(MAP4K3)

VKO:	123023219(MAP4K3)

PMUA:

114594816(MAP4K3)

PRAF:

128411297(MAP4K3)

ZVI:	118083027(MAP4K3)

HCG:	128322153(MAP4K3)

GJA:	107116191(MAP4K3)

STOW:

125424540(MAP4K3)

EMC:	129333428(MAP4K3)

XLA:	108716656(map4k3.L) 108717401

XTR:	100170570(map4k3)

NPR:	108788944(MAP4K3)

RTEM:

120937486(MAP4K3)

ACAT:

141141272(MAP4K3)

PADS:

140329082(MAP4K3)

BBUF:

120998778(MAP4K3)

BGAR:

122935913(MAP4K3)

DTC:	141063475(MAP4K3)

PWL:	138296161(MAP4K3)

MUO:	115465442(MAP4K3)

GSH:	117356614(MAP4K3)

DRE:	100005183(map4k3b) 558281(map4k3a)

SRX:	107715980 107720956(map4k3) 107737247 107751124

SANH:

107654892 107670867(map4k3) 107691292 107695069

SGH:	107555982 107570444 107583658

CCAR:

109104576 109105217 109108151(map4k3b) 109108174

CAUA:

113055300 113095780 113111060 113117494

CGIB:

127933339 127967809 127976258 128022215

PTET:

122354164(map4k3a) 122362064(map4k3b)

LROH:

127173442(map4k3a) 127179603(map4k3b)

GRF:	141293237(map4k3a) 141295278 141296176(map4k3b)

OMC:	131522924(map4k3b) 131549091(map4k3a)

PPRM:

120462833(map4k3b) 120480774(map4k3a)

RKG:	130083599(map4k3a) 130097477(map4k3b)

MAMB:

125256862(map4k3a) 125268703(map4k3b)

CIDE:

127498531 127522232

CERY:

137006110(map4k3b) 137021484(map4k3a)

MASI:

127411063 127425794 127427708 127455126

TROS:

130560040(map4k3b) 130570977(map4k3a)

TDW:	130410787(map4k3a) 130437131(map4k3b)

MANU:

129417232(map4k3b) 129427041(map4k3a)

PDAB:

135718810(map4k3a) 135737381(map4k3b)

IPU:	108269591(map4k3b)

IFU:	128613054(map4k3b)

PHYP:

113545012

SMEO:

124389633(map4k3b)

TFD:	113641148(map4k3b)

TVC:	132851952(map4k3b)

CGAR:

128535535(map4k3b)

NGRA:

132894084(map4k3b)

TRN:	134303891(map4k3a) 134325325(map4k3b)

AMEX:

103026300(map4k3b) 103028458(map4k3a)

CMAO:

118803795(map4k3a) 118824176(map4k3b)

EEE:	113577684(map4k3)

CHAR:

105893436(map4k3b) 105905793

SPIL:

134064145(map4k3b) 134095563(map4k3a)

ASAD:

121684848(map4k3b) 121719271(map4k3a)

TRU:	101063416(map4k3)

TFS:

130533479

LCO:

104930995

TBEN:

117499529

CGOB:

115019699(map4k3)

PGEO:

GACU:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116704848(map4k3)

PFLV:

114571755(map4k3)

GAT:

120821085

PPUG:

119214634

AFB:	129091987 129095394

CLUM:

117743752

PSWI:

130207452

CANA:

137780702

CVE:	137866643(map4k3a) 137888442

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

HTC:

ALAT:

ASTR:

MZE:	101484057(map4k3)

ONL:

100707684

OAU:

116324866

OLA:	101165250(map4k3)

OML:	112161627(map4k3b)

CSAI:

133463936

XMA:	102236868(map4k3)

XCO:	114138308(map4k3)

XHE:	116713100(map4k3)

PRET:

103476458(map4k3)

PLAI:

106940030

PMEI:

106906347(map4k3)

GAF:

PPRL:

CTUL:

GMU:

NFU:	107375798(map4k3)

KMR:

108244385

ALIM:

106523971(map4k3)

NWH:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

103386876(map4k3)

POV:	109633575(map4k3)

SSEN:

122781652

SSOE:

131473535

HHIP:

117775336

HSP:	118119106(map4k3a)

PPLT:

128453054(map4k3a)

SMAU:

118283607

LCF:	108873491 108882275

SDU:	111227400(map4k3) 111237581

SLAL:

111661998(map4k3)

XGL:	120796567 120799964

SSCV:

125978978

SBIA:

133509344(map4k3a)

PEE:

133409933

PTAO:

133485447(map4k3b)

BPEC:

110156784(map4k3)

ENY:

140351467

MALB:

109961122(map4k3)

BSPL:

114870599

SJO:

128372449

SSCO:

133992030

TTY:	137180463 137197398

GMH:	115559654(map4k3)

SASA:

106564791 106577155 106585154 106608247

STRU:

115153334 115178844 115193621 115208488

OTW:	112253152 112255843 112266023(map4k3a)

OMY:	110493790(map4k3a) 110502596 110530293

OGO:	124002571 124038330 124041149

ONE:	115113126 115134994 115142667

OKI:	109890041 109890305 109899792

OKE:	118378972 118389102 118399112

OMM:	135512238 135539449(map4k3a)

OCLA:

139370576 139381823 139412890

SALP:

111951738 111977670(map4k3) 112080714

SNH:	120017719 120046614 120065093(map4k3a)

SFON:

129836479 129839442 129858798

CCLU:

121553364 121571963 121572661 123481200

ELS:	105006890 105026822

OEP:	134009162(map4k3a) 134022787

SFM:	108927121 108933723

PKI:	111835682(map4k3) 111836856

AANG:

118217979 118220320(map4k3b)

AROT:

135244436 135245030

CCOG:

133117905 133122102(map4k3b)

LOC:	102691836(map4k3)

PSPA:

121315785(map4k3b) 121316887

ARUT:

117402962(map4k3b) 117411124(map4k3a)

PSEX:

120516953(map4k3b)

LCM:	102348521(MAP4K3)

CMK:	103179226(map4k3b)

RTP:	109937967(map4k3a)

CPLA:

CPUN:

HOC:

SCAU:

STOZ:

LERI:

129699516(map4k3a)

HAKA:

140730720(map4k3a)

PMRN:

116939696 116947204

LRJ:	133347356 133360164

BFO:

BBEL:

CIN:

SCLV:

LPIC:

AJJ:

AJC:

PFLL:

RZE:

CQU:	CpipJ_CPIJ010051

TCF:

PPOI:

DFR:

LPOL:

LOA:	LOAG_03187

CRG:

CANU:

CVN:

OED:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OSN:

MBR:	MONBRDRAFT_14676

» show all

Reference

PMID:19587239

Authors

Lam D, Dickens D, Reid EB, Loh SH, Moisoi N, Martins LM

Title

MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins.

Journal

Proc Natl Acad Sci U S A 106:11978-83 (2009)
DOI:10.1073/pnas.0900608106

Sequence

[hsa:8491]

Reference

PMID:9275185

Authors

Diener K, Wang XS, Chen C, Meyer CF, Keesler G, Zukowski M, Tan TH, Yao Z

Title

Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase.

Journal

Proc Natl Acad Sci U S A 94:9687-92 (1997)
DOI:10.1073/pnas.94.18.9687

Sequence

[hsa:8491]

LinkDB

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