KEGG ORTHOLOGY: K04419

ORTHOLOGY: K04419

Entry

K04419                      KO

Symbol

MAP3K11, MLK3

Name

mitogen-activated protein kinase kinase kinase 11 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04932

Non-alcoholic fatty liver disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04419  MAP3K11, MLK3; mitogen-activated protein kinase kinase kinase 11
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K04419  MAP3K11, MLK3; mitogen-activated protein kinase kinase kinase 11
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04419  MAP3K11, MLK3; mitogen-activated protein kinase kinase kinase 11
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04419  MAP3K11, MLK3; mitogen-activated protein kinase kinase kinase 11
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  MLK family
   K04419  MAP3K11, MLK3; mitogen-activated protein kinase kinase kinase 11

Other DBs

GO:

0004709

Genes

HSA:	4296(MAP3K11)

PTR:	451326(MAP3K11)

PPS:	100985853(MAP3K11)

GGO:	101148964(MAP3K11)

PON:	100456749(MAP3K11)

PPYG:

129008421(MAP3K11)

NLE:	100588106(MAP3K11)

HMH:	116469010(MAP3K11)

SSYN:

129469756(MAP3K11)

MCC:	716038(MAP3K11)

MCF:	101926191(MAP3K11)

MTHB:

126935336

MNI:	105469582(MAP3K11)

CSAB:

103227627(MAP3K11)

CATY:

105577434(MAP3K11)

PANU:

101018751(MAP3K11)

TGE:	112606485(MAP3K11)

MLEU:

105528446(MAP3K11)

RRO:	104664818(MAP3K11)

RBB:	108543509(MAP3K11)

TFN:	117081404(MAP3K11)

PTEH:

111522421(MAP3K11)

CANG:

105512159(MAP3K11)

CJC:	100387775(MAP3K11)

SBQ:	101039966(MAP3K11)

CIMI:

108310404(MAP3K11)

ANAN:

105724419(MAP3K11)

CSYR:

103252329(MAP3K11)

MMUR:

105878530(MAP3K11)

LCAT:

123641357(MAP3K11)

ERUF:

138385336(MAP3K11)

PCOQ:

105827407(MAP3K11)

OGA:	100957362(MAP3K11)

MMU:	26403(Map3k11)

MCAL:

110285431(Map3k11)

MPAH:

110327022(Map3k11)

RNO:	309168(Map3k11)

MCOC:

116103407(Map3k11)

ANU:	117718167(Map3k11)

ASYL:

127692193(Map3k11)

MUN:	110549306(Map3k11)

CGE:	100762677(Map3k11)

MAUA:

101837014(Map3k11)

PROB:

127228712(Map3k11)

PLEU:

114682069(Map3k11)

PMAV:

102911706(Map3k11)

MORG:

121454055(Map3k11)

MFOT:

126498193

AAMP:

119814316(Map3k11)

CNL:	130880596(Map3k11)

NGI:	103724991(Map3k11)

HGL:	101718575(Map3k11)

CPOC:

100730722(Map3k11)

CCAN:

109687144(Map3k11)

DORD:

105989103(Map3k11)

DSP:	122104856(Map3k11)

DMER:

138818582 138824306

PLOP:

125362755(Map3k11)

NCAR:

124960176

MMMA:

107156939(Map3k11)

ITI:	101967688(Map3k11)

OCU:

100356691

OPI:	101530811(MAP3K11)

OCZ:	121150330(MAP3K11)

TUP:	102490022(MAP3K11)

GVR:	103595332(MAP3K11)

CFA:	483732(MAP3K11)

CLUD:

112659238(MAP3K11)

VVP:	112924257(MAP3K11)

VLG:	121471327(MAP3K11)

NPO:	129502089(MAP3K11)

AML:	100480913(MAP3K11)

UMR:	103679581(MAP3K11)

UAH:	113244105(MAP3K11)

UAR:	123778278(MAP3K11)

ELK:

111149430

LLV:

125078716

MPUF:

101679834(MAP3K11)

MNP:	132018706(MAP3K11)

MLK:	131815534(MAP3K11)

NVS:	122913120(MAP3K11)

ORO:	101382287(MAP3K11)

EJU:	114220535(MAP3K11)

ZCA:	113913949(MAP3K11)

MLX:	118016057(MAP3K11)

MANO:

123856955(MAP3K11)

NSU:	110575984(MAP3K11)

LWW:	102729057(MAP3K11)

FCA:	101098654(MAP3K11)

PYU:	121023958(MAP3K11)

PCOO:

112851937(MAP3K11)

PBG:	122484467(MAP3K11)

PVIV:

125176493(MAP3K11)

LRUF:

124504951

LGF:	123602295(MAP3K11)

AJU:

106971139

PPAD:

109246746(MAP3K11)

PUC:

125912120

PLEZ:

122199168(MAP3K11)

HHV:	120240184(MAP3K11)

CCRU:

144227975(MAP3K11)

BTA:	514210(MAP3K11)

BOM:	102279268(MAP3K11)

BIU:	109554270(MAP3K11)

BJV:	133241452(MAP3K11)

BBUB:

102399115(MAP3K11)

BKE:	129652326(MAP3K11)

BBIS:

104987086(MAP3K11)

CHX:	102173267(MAP3K11)

OAS:	101108969(MAP3K11)

OCAN:

138427042(MAP3K11)

BTAX:

128069202(MAP3K11)

CSUM:

138083152(MAP3K11)

ODA:	120874631(MAP3K11)

CCAD:

122430632(MAP3K11)

MREE:

136169739(MAP3K11)

OVR:	110145929(MAP3K11)

MBEZ:

129548770(MAP3K11)

SSC:	100736741(MAP3K11)

CFR:	102506717(MAP3K11)

CBAI:

105070717(MAP3K11)

CDK:	105102638(MAP3K11)

VPC:	102539713(MAP3K11)

BACU:

103004845(MAP3K11)

BMUS:

118898929(MAP3K11)

LVE:	103089110(MAP3K11)

OOR:	101269437(MAP3K11)

LALB:

132525639(MAP3K11)

GMF:	115840530(MAP3K11)

DDP:	132430075(MAP3K11)

SCOO:

307190696(MAP3K11)

DLE:	111183748(MAP3K11)

PCAD:

102973912(MAP3K11)

PSIU:

116757499(MAP3K11)

PPHC:

136126468(MAP3K11)

NASI:

112401971(MAP3K11)

ECB:	100057319(MAP3K11)

EPZ:	103540552(MAP3K11)

EAI:	106833665(MAP3K11)

MYB:	102253871(MAP3K11)

MYD:	102771577(MAP3K11)

MMYO:

118665301(MAP3K11)

MLF:	102423631(MAP3K11)

MDT:	132241415(MAP3K11)

MYUM:

139018749(MAP3K11)

PKL:	118706871(MAP3K11)

EFUS:

103290985(MAP3K11)

MNA:	107533546(MAP3K11)

DRO:	112317244(MAP3K11)

SHON:

118991735(MAP3K11)

AJM:	119050280(MAP3K11)

PDIC:

114499399(MAP3K11)

PHAS:

123829327(MAP3K11)

MMF:	118628517(MAP3K11)

PPAM:

129068574(MAP3K11)

HAI:	109384179(MAP3K11)

RFQ:	117029931(MAP3K11)

PALE:

102878894(MAP3K11)

PGIG:

120584643(MAP3K11)

PVP:	105297902(MAP3K11)

RAY:	107497495(MAP3K11)

MJV:	108402621(MAP3K11)

TOD:	119249975(MAP3K11)

SARA:

101537768(MAP3K11)

SFUM:

130040015(MAP3K11)

SETR:

126018025(MAP3K11)

LAV:	100655585(MAP3K11)

TMU:

101340392

ETF:	101662607(MAP3K11)

DNM:	101416709(MAP3K11)

MDO:	100030111(MAP3K11)

GAS:	123251483(MAP3K11)

SHR:	100932989(MAP3K11)

AFZ:

127539909

PCW:	110195402(MAP3K11)

TVP:	118854274(MAP3K11)

PBRV:

138144854(MAP3K11)

MLAO:

141518771(MAP3K11)

OAA:	107547228(MAP3K11)

TACU:

119943551(MAP3K11)

PMOA:

120511152

PRUF:

121351434

ATRC:

139586322(MAP3K11)

PHI:	102102657(MAP3K11)

PMAJ:

107199524

ACOE:

138100350(MAP3K11)

ETL:	114070364(MAP3K11)

ZLE:	135460332(MAP3K11)

SVG:	106863846(MAP3K11)

CCIC:

134055526(MAP3K11)

AGEN:

126034115

BBUT:

142025663(MAP3K11)

CBOR:

142074534(MAP3K11)

CBOY:

140660577(MAP3K11)

ASN:	102371337(MAP3K11)

AMJ:	102570911(MAP3K11)

PSS:	102443925(MAP3K11)

CIZ:	142019093(MAP3K11)

CMY:	102946051(MAP3K11)

CCAY:

125640179(MAP3K11)

LKP:	140914373(MAP3K11)

NDS:	141990619(MAP3K11)

CPIC:

101939688(MAP3K11)

TST:	117880530(MAP3K11)

CABI:

116835514(MAP3K11)

MRV:	120369247(MAP3K11)

EMQ:	137150170(MAP3K11)

ASAO:

132764355(MAP3K11)

PVT:	110089958(MAP3K11)

SUND:

121915587

PBI:	103051131(MAP3K11)

PMUR:

107288998(MAP3K11)

CTIG:

120318554(MAP3K11)

TSR:	106550493(MAP3K11)

PGUT:

117669712(MAP3K11)

PCAE:

139322250(MAP3K11)

APRI:

131186396(MAP3K11)

PTEX:

113447461(MAP3K11)

NSS:	113428634 113428655

VKO:	123032609(MAP3K11)

PMUA:

114586443(MAP3K11)

PRAF:

128404201(MAP3K11)

ZVI:	118076522(MAP3K11)

HCG:	128337353(MAP3K11)

GJA:	107121069(MAP3K11)

STOW:

125442865(MAP3K11)

EMC:	129337025(MAP3K11)

PWL:	138259917(MAP3K11)

MUO:	115480131(MAP3K11)

GSH:	117364494(MAP3K11)

DRE:

101886393

DAES:

130231495

SRX:	107714886 107732687

SANH:

107670406 107679954

SGH:	107552439 107575154

CCAR:

109061637 109105294

CAUA:

113080237 113093140 113105394

CGIB:

PTET:

LROH:

GRF:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

MASI:

TROS:

TDW:

MANU:

PDAB:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

ASAD:

TRU:

TFS:

TNG:	GSTEN00006262G001

NCC:	104965777(map3k11)

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

SVIT:

ECRA:

ESP:

PFLV:

114545451(map3k11)

PFLT:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

CVE:

AMIR:

MSAM:

SCHU:

EARM:

CUD:

SPUL:

LMIX:

HTC:

ALAT:

ASTR:

PKLU:

LCO:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

103480213(map3k11)

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

LTU:

MCEP:

AOCE:

EJA:

BFRE:

LCF:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

SDU:	111226905(map3k11)

SLAL:

111670445(map3k11)

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

ENY:

MALB:

BSPL:

SJO:

SSCO:

TTY:

GMH:

SASA:

STRU:

OTW:	112214779 112261013

OMY:	110500695 110531839

OGO:	124007706 124013990

ONE:	115133628 115138163(map3k11)

OKI:	109897089 109906581

OKE:	118368669 118391901

OMM:	135510696 135516399

OCLA:

139379057 139416163

SALP:

111955112 111960239

SNH:	120030570 120049599

SFON:

129835185 129865838

CCLU:

121554741 121571017

ELS:	105020697(map3k11)

OEP:

134009857

SFM:	108934141 114910404

PKI:	111851979 111855427(map3k11)

AANG:

118224319 118235421

AROT:

135250008 135263562

CCOG:

133123790 133132153

LOC:	102695953(map3k11)

PSPA:

121310071

ARUT:

117398668 117967786

PSEX:

120539265

LCM:	102364487(MAP3K11)

CPUN:

HOC:

LERI:

HAKA:

SRE:	PTSG_08045

» show all

Reference

PMID:18855897

Authors

Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD

Title

MAP3Ks as central regulators of cell fate during development.

Journal

Dev Dyn 237:3102-14 (2008)
DOI:10.1002/dvdy.21750

Reference

PMID:8195146

Authors

Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q, Godowski PJ

Title

Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.

Journal

J Biol Chem 269:15092-100 (1994)

Sequence

[hsa:4296]

LinkDB

DBGET integrated database retrieval system