KEGG   ORTHOLOGY: K04443
Entry
K04443                      KO                                     
Symbol
MAPKAPK2
Name
mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
Pathway
map04010  MAPK signaling pathway
map04218  Cellular senescence
map04361  Axon regeneration
map04370  VEGF signaling pathway
map04625  C-type lectin receptor signaling pathway
map04722  Neurotrophin signaling pathway
map05167  Kaposi sarcoma-associated herpesvirus infection
map05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
   04370 VEGF signaling pathway
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
  09158 Development and regeneration
   04361 Axon regeneration
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  MAPKAPK family [OT]
   K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
Genes
HSA: 9261(MAPKAPK2)
PTR: 744091(MAPKAPK2)
PPS: 100968858(MAPKAPK2)
GGO: 101151250(MAPKAPK2)
PON: 100446757(MAPKAPK2)
NLE: 100579643(MAPKAPK2)
MCC: 695044(MAPKAPK2)
MCF: 102131033(MAPKAPK2)
CSAB: 103230194(MAPKAPK2)
CATY: 105576691(MAPKAPK2)
PANU: 101024625(MAPKAPK2)
TGE: 112629024(MAPKAPK2)
RRO: 104661739(MAPKAPK2)
RBB: 108535144(MAPKAPK2)
TFN: 117076159(MAPKAPK2)
PTEH: 111522809(MAPKAPK2)
CJC: 100393258(MAPKAPK2)
SBQ: 101052249(MAPKAPK2)
CSYR: 103258003(MAPKAPK2)
MMUR: 105869016(MAPKAPK2)
OGA: 100966784(MAPKAPK2)
MMU: 17164(Mapkapk2)
MCAL: 110294905(Mapkapk2)
MPAH: 110321250(Mapkapk2)
RNO: 289014(Mapkapk2)
MCOC: 116098772(Mapkapk2)
MUN: 110550321(Mapkapk2)
CGE: 100762218(Mapkapk2)
PLEU: 114698053(Mapkapk2)
NGI: 103725934(Mapkapk2)
HGL: 101708612(Mapkapk2)
CPOC: 100715906(Mapkapk2)
CCAN: 109688375(Mapkapk2)
DORD: 105986431(Mapkapk2)
DSP: 122109435(Mapkapk2)
NCAR: 124962236
OCU: 100009438(MAPKAPK2)
OPI: 101529341(MAPKAPK2)
TUP: 102483974(MAPKAPK2)
CFA: 490263(MAPKAPK2)
VVP: 112910998(MAPKAPK2)
VLG: 121492957(MAPKAPK2)
AML: 100483931(MAPKAPK2)
UMR: 103657756(MAPKAPK2)
UAH: 113242594(MAPKAPK2)
UAR: 123785786(MAPKAPK2)
ELK: 111151153
LLV: 125085671
MPUF: 101672433(MAPKAPK2)
ORO: 101380197(MAPKAPK2)
EJU: 114221927(MAPKAPK2)
ZCA: 113932093(MAPKAPK2)
MLX: 118014249(MAPKAPK2)
FCA: 101090833(MAPKAPK2)
PYU: 121022432(MAPKAPK2)
PBG: 122476270(MAPKAPK2)
PTG: 102961644(MAPKAPK2)
PPAD: 109250406(MAPKAPK2)
AJU: 106981771(MAPKAPK2)
HHV: 120245595(MAPKAPK2)
BTA: 788091(MAPKAPK2)
BOM: 102274647(MAPKAPK2)
BIU: 109570101(MAPKAPK2)
BBUB: 102401914(MAPKAPK2)
CHX: 102184079(MAPKAPK2)
OAS: 101118118(MAPKAPK2)
ODA: 120879875(MAPKAPK2)
SSC: 100521986(MAPKAPK2)
CFR: 102508766(MAPKAPK2)
CBAI: 105075427(MAPKAPK2)
CDK: 105098610(MAPKAPK2)
VPC: 102537860(MAPKAPK2)
BACU: 102999332(MAPKAPK2)
LVE: 103082742(MAPKAPK2)
OOR: 101272142(MAPKAPK2)
DLE: 111184749(MAPKAPK2)
PCAD: 102974346(MAPKAPK2)
PSIU: 116751460(MAPKAPK2)
ECB: 100055510(MAPKAPK2) 102147500
EPZ: 103567219(MAPKAPK2)
EAI: 106823339
MYD: 102775090(MAPKAPK2)
MMYO: 118672767(MAPKAPK2)
MLF: 102430855(MAPKAPK2)
MNA: 107538913(MAPKAPK2)
PKL: 118721314(MAPKAPK2)
HAI: 109374513(MAPKAPK2)
DRO: 112318256(MAPKAPK2)
SHON: 119001642(MAPKAPK2)
AJM: 119056790(MAPKAPK2)
PDIC: 114511988(MAPKAPK2)
PHAS: 123820667(MAPKAPK2)
MMF: 118637117(MAPKAPK2)
RFQ: 117015230(MAPKAPK2)
PALE: 102887540(MAPKAPK2)
PGIG: 120617932(MAPKAPK2)
PVP: 105308925(MAPKAPK2)
RAY: 107502219(MAPKAPK2)
MJV: 108403019(MAPKAPK2)
TOD: 119234496(MAPKAPK2)
SARA: 101552098(MAPKAPK2)
LAV: 100658205(MAPKAPK2)
TMU: 101342996
DNM: 101415355(MAPKAPK2)
MDO: 100014871(MAPKAPK2)
GAS: 123247441(MAPKAPK2)
SHR: 100917693(MAPKAPK2)
PCW: 110219609(MAPKAPK2)
OAA: 100092220(MAPKAPK2)
GGA: 419847(MAPKAPK2)
PCOC: 116236993(MAPKAPK2)
MGP: 100548519(MAPKAPK2)
CJO: 107324781(MAPKAPK2)
NMEL: 110388241(MAPKAPK2)
APLA: 101789944(MAPKAPK2)
ACYG: 106041349(MAPKAPK2)
AFUL: 116498743(MAPKAPK2)
TGU: 115498549(MAPKAPK2)
LSR: 110473090(MAPKAPK2)
SCAN: 103822392(MAPKAPK2)
PMOA: 120497623(MAPKAPK2)
OTC: 121345510(MAPKAPK2)
PRUF: 121349766(MAPKAPK2)
GFR: 102044089(MAPKAPK2)
PHI: 102106065(MAPKAPK2)
PMAJ: 107214766(MAPKAPK2)
CCAE: 111939739(MAPKAPK2)
CCW: 104692513(MAPKAPK2)
ETL: 114063132(MAPKAPK2)
FPG: 101911197(MAPKAPK2)
FCH: 102050830(MAPKAPK2)
CLV: 102085947(MAPKAPK2)
EGZ: 104134508(MAPKAPK2)
NNI: 104013194(MAPKAPK2)
ACUN: 113488889(MAPKAPK2)
TALA: 104362712(MAPKAPK2)
PADL: 103919783(MAPKAPK2)
ACHC: 115335241(MAPKAPK2)
AAM: 106495796(MAPKAPK2)
AROW: 112971664(MAPKAPK2)
NPD: 112944579(MAPKAPK2)
DNE: 112990346(MAPKAPK2)
ASN: 102383452(MAPKAPK2)
AMJ: 102563674(MAPKAPK2)
CPOO: 109317923(MAPKAPK2)
GGN: 109295089(MAPKAPK2)
PSS: 102445709(MAPKAPK2)
CMY: 102948283(MAPKAPK2)
CPIC: 101936401(MAPKAPK2)
TST: 117875763(MAPKAPK2)
CABI: 116832084(MAPKAPK2)
MRV: 120403398(MAPKAPK2)
ACS: 100562891(mapkapk2)
PVT: 110088404(MAPKAPK2)
SUND: 121928398(MAPKAPK2)
PBI: 103050162(MAPKAPK2)
TSR: 106544613(MAPKAPK2)
PGUT: 117663862(MAPKAPK2)
VKO: 123031422(MAPKAPK2)
PMUA: 114599328(MAPKAPK2)
ZVI: 118088174(MAPKAPK2)
GJA: 107124264(MAPKAPK2)
XLA: 432084(mapkapk2.L) 495118(mapkapk2.S)
XTR: 550101(mapkapk2)
NPR: 108793180(MAPKAPK2)
RTEM: 120927097(MAPKAPK2)
BBUF: 120995002(MAPKAPK2)
BGAR: 122933460(MAPKAPK2)
DRE: 327321(mapkapk2a) 557648(mapkapk2b)
PPRM: 120480446(mapkapk2a) 120492589(mapkapk2b)
IPU: 108255116(mapkapk2a)
PHYP: 113539676(mapkapk2)
SMEO: 124402585(mapkapk2a)
TFD: 113641569(mapkapk2a)
EEE: 113578783 113579161(mapkapk2)
TRU: 101074595
ELY: 117257264(mapkapk2a) 117257781
PLEP: 121947328 121953644(mapkapk2a)
SLUC: 116062189 116066885(mapkapk2a)
ECRA: 117943571(mapkapk2a) 117947996
PFLV: 114554459(mapkapk2) 114559084
GAT: 120829843 120835200(mapkapk2a)
PPUG: 119223602 119229917(mapkapk2a)
MSAM: 119885911(mapkapk2a) 119905857
CUD: 121504519(mapkapk2a) 121517754
MZE: 101471444
ONL: 100695012(mapkapk2)
OAU: 116326443(mapkapk2a)
OLA: 101157364(mapkapk2)
OML: 112145422(mapkapk2a)
XMA: 102228209(mapkapk2)
XCO: 114135726(mapkapk2)
XHE: 116710744(mapkapk2)
PRET: 103464872
PFOR: 103144319(mapkapk2)
PLAI: 106958310(mapkapk2)
PMEI: 106933928(mapkapk2)
GAF: 122833449(mapkapk2a)
CVG: 107083314
CTUL: 119791790(mapkapk2a)
GMU: 124857538(mapkapk2a)
NFU: 107385601(mapkapk2)
KMR: 108235782(mapkapk2a)
ALIM: 106513301(mapkapk2)
NWH: 119411956(mapkapk2a)
AOCE: 111566562
CSEM: 103386073(mapkapk2)
POV: 109629213
SSEN: 122768478
HHIP: 117762104(mapkapk2a)
SLAL: 111667188 111667810(mapkapk2)
XGL: 120783136(mapkapk2a) 120804154
HCQ: 109522522
BPEC: 110171263
MALB: 109956193
SASA: 106566648(MAPK2) 106571864(MAPK2) 106583822
ELS: 105013205
PKI: 111834362 111854424(mapkapk2)
AANG: 118207922 118211116(mapkapk2a)
LOC: 102692535(mapkapk2)
ARUT: 117394845 117428195(mapkapk2a)
LCM: 102362783(MAPKAPK2)
CMK: 103182495
RTP: 109917680 109918144(mapkapk2) 109938847
BFO: 118416909
BBEL: 109466262
SPU: 582861
APLC: 110983981
DME: Dmel_CG3086(MAPk-Ak2)
DER: 6550842
DSE: 116802035
DSI: Dsimw501_GD16235(Dsim_GD16235)
DAN: 6504147
DSR: 110183053
DPE: 6596887
DMN: 108152380
DWI: 6648676
DGR: 6565865
DAZ: 108618586
DNV: 108657309
DHE: 111592701
DVI: 6633683
CCAT: 101451768
BOD: 106614392
MDE: 101898240
SCAC: 106093351
LCQ: 111679252
ACOZ: 120954922
AARA: 120900163
AAG: 5571923
CPII: 120420319
CNS: 116338636
ACER: 107996893
ALAB: 122720438
BIM: 105682130
BBIF: 117206821
BVK: 117234866
BVAN: 117159833
BTER: 105667115
BPYO: 122571960
OBB: 114870970
NMEA: 116427598
CGIG: 122397677
SOC: 105194280
MPHA: 105837757
AEC: 105151682
ACEP: 105623115
PBAR: 105425719
VEM: 105563295
HST: 105181030
DQU: 106742764
CFO: 105250864
FEX: 115239537
LHU: 105670887
PGC: 109851777
OBO: 105283794
PCF: 106785969
PFUC: 122518417
VPS: 122632529
NVI: 100120769
CSOL: 105359409
TPRE: 106650361
CGLO: 123269554
FAS: 105272233
AGIF: 122851700
CCIN: 107267395
TCA: 662443
DPA: 109537992
SOY: 115875025
ATD: 109608310
CSET: 123321782
AGB: 108917016
LDC: 111511737
NVL: 108558938
APLN: 108733793
PPYR: 116181087
OTU: 111425293
BMOR: 101742228
BMAN: 114244194
BANY: 112045104
PMAC: 106721268
PPOT: 106106959
PXU: 106124929
PRAP: 110997980
ZCE: 119838215
HAW: 110382371
TNL: 113498486
SLIU: 111354768
PXY: 105381503
API: 100166092
DNX: 107167186
AGS: 114129461
RMD: 113556474
BTAB: 109034577
DCI: 103506447
CLEC: 106665318
HHAL: 106685479
NLU: 111061251
FOC: 113214780
ZNE: 110834585
CSEC: 111873961
FCD: 110861760
DMK: 116924800
PVM: 113817177
PJA: 122262852
PCHN: 125033501
HAME: 121859725
PCLA: 123757486
PTRU: 123506392
HAZT: 108679004
EAF: 111698687
DSV: 119461843
RSAN: 119395715
RMP: 119174097
VDE: 111250464
VJA: 111261998
TUT: 107371283
DPTE: 113796622
DFR: 124499888
CSCU: 111633497
PTEP: 107448225
CEL: CELE_C44C8.6(mak-2)
CBR: CBG_13977(Cbr-mak-2)
PCAN: 112571792
BGT: 106066532
GAE: 121367532
HRF: 124122593
HRJ: 124278764
CRG: 105320307
MYI: 110443430
PMAX: 117331350
MMER: 123529433
OBI: 106882434
LAK: 106160916
EGL: EGR_00520
NVE: 5512145
ATEN: 116305785
ADF: 107355156
AMIL: 114969353
PDAM: 113674071
SPIS: 111339198
DGT: 114524637
HMG: 100212998
AQU: 100640836
 » show all
Reference
PMID:8179591
  Authors
Zu YL, Wu F, Gilchrist A, Ai Y, Labadia ME, Huang CK
  Title
The primary structure of a human MAP kinase activated protein kinase 2.
  Journal
Biochem Biophys Res Commun 200:1118-24 (1994)
DOI:10.1006/bbrc.1994.1566
  Sequence
[hsa:9261]
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