KEGG ORTHOLOGY: K04578

ORTHOLOGY: K04578

Entry

K04578                      KO

Symbol

CRHR1

Name

corticotropin releasing hormone receptor 1

Pathway

map04024

cAMP signaling pathway

map04080

Neuroactive ligand-receptor interaction

map04081

Hormone signaling

map04730

Long-term depression

map04934

Cushing syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K04578  CRHR1; corticotropin releasing hormone receptor 1
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04578  CRHR1; corticotropin releasing hormone receptor 1
   04081 Hormone signaling
    K04578  CRHR1; corticotropin releasing hormone receptor 1
09150 Organismal Systems
  09156 Nervous system
   04730 Long-term depression
    K04578  CRHR1; corticotropin releasing hormone receptor 1
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04578  CRHR1; corticotropin releasing hormone receptor 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04578  CRHR1; corticotropin releasing hormone receptor 1
G protein-coupled receptors [BR:ko04030]
Secretin receptor family
  Hypothalamic hormone
   Corticotropin-releasing hormone (CRH)
    K04578  CRHR1; corticotropin releasing hormone receptor 1

Other DBs

GO:

0015056

TC:	9.A.14.4.3

Genes

HSA:	1394(CRHR1)

PTR:	107966392(CRHR1)

PPS:	100986244(CRHR1)

GGO:	101136616(CRHR1)

PON:	100432200(CRHR1)

PPYG:

129017906(CRHR1)

NLE:	100602096(CRHR1)

HMH:	116475000(CRHR1)

SSYN:

129470177(CRHR1)

MCC:	574095(CRHR1)

MCF:	102124531(CRHR1)

MTHB:

126938927

MNI:	105468357(CRHR1)

CSAB:

103243260(CRHR1)

CATY:

105585760(CRHR1)

PANU:

101003248(CRHR1)

TGE:	112609410(CRHR1)

MLEU:

105555142(CRHR1)

RRO:	104682394(CRHR1)

RBB:	108529368(CRHR1)

TFN:	117087370(CRHR1)

PTEH:

111529275(CRHR1)

CANG:

105520287(CRHR1)

CJC:	100405475(CRHR1) 103793141

SBQ:	101028684(CRHR1)

CIMI:

108318307(CRHR1)

ANAN:

105711245(CRHR1)

CSYR:

103253630

MMUR:

105863672(CRHR1)

LCAT:

123620564(CRHR1)

PCOQ:

105819072(CRHR1)

OGA:	100952699(CRHR1)

MMU:	12921(Crhr1)

MCAL:

110304426(Crhr1)

MPAH:

110331134(Crhr1)

RNO:	58959(Crhr1)

MCOC:

116078094(Crhr1)

ANU:	117709928(Crhr1)

ASYL:

127693610(Crhr1)

MUN:	110545638(Crhr1)

CGE:

100769844

MAUA:

101829697(Crhr1)

PROB:

127217656(Crhr1)

PLEU:

114702275(Crhr1)

MORG:

121436283(Crhr1)

MFOT:

126487546

AAMP:

119812485(Crhr1)

NGI:	103724769(Crhr1)

HGL:	101721828(Crhr1)

CPOC:

100729987(Crhr1)

CCAN:

109684802

DORD:

105998522(Crhr1)

DSP:	122103305(Crhr1)

PLOP:

125366289(Crhr1)

NCAR:

124980578

MMMA:

107160520(Crhr1)

ITI:	101961253(Crhr1)

OCU:	100302436(CRHR1)

OPI:	101519963(CRHR1)

TUP:	102478239(CRHR1)

GVR:	103601001 103601002

CFA:	610380(CRHR1)

CLUD:

112652949(CRHR1)

VVP:

112920686

VLG:	121472725(CRHR1)

NPO:	129493694(CRHR1)

AML:	100475512(CRHR1)

UMR:

103665890

UAR:	123802993(CRHR1)

ELK:

111158111

LLV:

125087989

MPUF:

101681992

MNP:	132004276(CRHR1)

MLK:	131816382(CRHR1)

NVS:

122907570

ORO:	101373186(CRHR1)

EJU:

114196741

ZCA:

113908194

MLX:

118027169

NSU:	110570357(CRHR1)

LWW:

102750183

FCA:	101089308(CRHR1)

PYU:	121020148(CRHR1)

PBG:	122485732(CRHR1)

PVIV:

125151549(CRHR1)

LRUF:

124512837

LGF:	123603883(CRHR1)

AJU:

106988835

PTG:	102962839(CRHR1)

PPAD:

109259750(CRHR1)

PUC:

125927349

PLEZ:

122206998(CRHR1)

HHV:	120244274(CRHR1)

BTA:	281716(CRHR1)

BOM:	102272695(CRHR1)

BIU:	109573320(CRHR1)

BBUB:

102414459(CRHR1)

BBIS:

104983012(CRHR1)

CHX:	102191647(CRHR1)

OAS:	443025(CRHR1)

BTAX:

128065457(CRHR1)

CSUM:

138082705(CRHR1)

ODA:	120866984(CRHR1)

CCAD:

122440095(CRHR1)

MREE:

136149264(CRHR1)

OVR:	110129538(CRHR1)

MBEZ:

129544520(CRHR1)

SSC:	397426(CRHR1)

CFR:	102507830(CRHR1)

CBAI:

105071482(CRHR1)

CDK:	105090500(CRHR1)

VPC:	102527109(CRHR1)

BACU:

103013802(CRHR1)

BMUS:

118887167(CRHR1)

LVE:

103090142

OOR:	101278576(CRHR1)

LALB:

132510825(CRHR1)

DLE:	111182580(CRHR1)

PCAD:

102995828(CRHR1)

PSIU:

116746306(CRHR1)

NASI:

112410282(CRHR1)

ECB:	100065598(CRHR1)

EPZ:	103552912(CRHR1)

EAI:	106836493(CRHR1)

MYB:	102259439(CRHR1)

MYD:	102756414(CRHR1)

MMYO:

118671808(CRHR1)

MLF:	102426185(CRHR1)

MDT:	132218537(CRHR1)

MYUM:

138993640(CRHR1)

PKL:	118726654(CRHR1)

EFUS:

103293166(CRHR1)

MNA:	107530260(CRHR1)

DRO:	112316287(CRHR1)

SHON:

119003697(CRHR1)

AJM:	119062712(CRHR1)

PDIC:

114503302(CRHR1)

PHAS:

123817566(CRHR1)

MMF:	118634053(CRHR1)

PPAM:

129071522(CRHR1)

HAI:	109380260(CRHR1)

RFQ:	117013784(CRHR1)

PALE:

102878226(CRHR1)

PGIG:

120589266(CRHR1)

PVP:

105303517

RAY:	107508175(CRHR1)

MJV:	108403491(CRHR1)

TOD:	119231974(CRHR1)

SARA:

101537586(CRHR1)

SFUM:

130035871(CRHR1)

SETR:

126018034(CRHR1)

LAV:	100659551(CRHR1)

TMU:

101340626

ETF:	101648674(CRHR1)

DNM:

101418035

MDO:	100024819(CRHR1)

GAS:	123246189(CRHR1)

SHR:	100919690(CRHR1)

AFZ:

127560381

PCW:	110215928(CRHR1)

TVP:

118846982

PBRV:

138152761(CRHR1)

OAA:

100083324

TACU:

119934972(CRHR1)

GGA:	374218(CRHR1)

PCOC:

116233825

MGP:

100540152

CJO:	107325280(CRHR1)

TPAI:

128088733(CRHR1)

LMUT:

125684656(CRHR1)

NMEL:

110388633(CRHR1)

APLA:

101803845

ACYG:

106045998(CRHR1)

CATA:

118258894(CRHR1)

AFUL:

116498513(CRHR1)

TGU:

100223670

LSR:	110476969(CRHR1)

SCAN:

103821679

PMOA:

120498402

OTC:	121333017(CRHR1)

PRUF:

121350507(CRHR1)

ATRC:

139601626(CRHR1)

GFR:	102044709(CRHR1)

FAB:	101806078(CRHR1)

OMA:	130264095(CRHR1)

PHI:	102099242(CRHR1)

PMAJ:

107215316

CCAE:

111939929(CRHR1)

CCW:

104698492

CBRC:

103616997

ACOE:

138099340

ETL:	114066938(CRHR1)

ZAB:

102064549

ZLE:	135458496(CRHR1)

ACHL:

103808047

SVG:	106858243(CRHR1)

MMEA:

130583466(CRHR1)

HRT:	120763869(CRHR1)

SATI:

136372351

CCIC:

134053145(CRHR1)

FPG:	101910362(CRHR1)

FCH:

102049124

CCRI:

104167815

NNT:	104408321(CRHR1)

SHAB:

115617940(CRHR1)

ACUN:

113489259(CRHR1)

TALA:

104363087(CRHR1)

ACHC:

115345152(CRHR1)

HALD:

104320084

HLE:	104827971(CRHR1)

AGEN:

HHAR:

GCL:

LDI:

MNB:

DPUB:

PPUS:

135191759(CRHR1)

AVIT:

104271740

BRHI:

104488910

EGZ:	104134576(CRHR1)

NNI:	104012264(CRHR1)

PCRI:

104037081

PCAO:

104045396(CRHR1)

PADL:

103926077(CRHR1)

AFOR:

103906056(CRHR1)

FGA:	104079143(CRHR1)

GSTE:

104264195(CRHR1)

CLV:

102089639

MUI:

104543512

PGUU:

104471269(CRHR1)

PLET:

104623091

EHS:

104512215

CMAC:

104486504

CUCA:

104054394(CRHR1)

TEO:	104382683(CRHR1)

BREG:

104636334

OHA:

104338678

ACAR:

104526974(CRHR1)

CPEA:

104390235(CRHR1)

CVF:	104285398(CRHR1)

RTD:	128919411(CRHR1)

CRID:

134524515(CRHR1)

AAM:

106497452

AROW:

112962772(CRHR1)

NPD:	112960291(CRHR1)

TGT:

104568392

DNE:	112982770(CRHR1)

SCAM:

104144764(CRHR1)

ASN:	102383267(CRHR1)

AMJ:	102563512(CRHR1)

CPOO:

109318976

GGN:

109302081

PSS:	102445239(CRHR1)

CMY:

CCAY:

DCC:

CPIC:

TST:	117869294(CRHR1)

CABI:

116839504(CRHR1)

MRV:

120385088

ACS:	100554822(crhr1)

ASAO:

132778228(CRHR1)

PVT:

110074907

SUND:

121935789(CRHR1)

PBI:	103053136(CRHR1)

PMUR:

107303101

CTIG:

120316066

TSR:	106551069(CRHR1)

PGUT:

117664611(CRHR1)

APRI:

131198562(CRHR1)

PTEX:

NSS:

VKO:

PMUA:

PRAF:

128400103(CRHR1)

ZVI:	118094684(CRHR1)

HCG:	128330034(CRHR1)

STOW:

125445128(CRHR1)

EMC:	129339099(CRHR1)

XLA:	108700863(crhr1.2.L) 373580(crhr1.2.S)

XTR:	100498637(crhr1.2)

NPR:	108802546(CRHR1)

RTEM:

120918292(CRHR1)

BBUF:

121005655

BGAR:

122942056

PWL:

138299622

MUO:	115481735 115481905

GSH:

117347478

DRE:	567940(crhr1)

SRX:	107740665 107754311

SANH:

107662410 107694956

SGH:	107582913 107585084

CCAR:

109101841

CAUA:

113046788 113048113

CGIB:

127946907 127952688

PTET:

122334174(crhr1)

LROH:

127159097(crhr1)

OMC:	131536437(crhr1)

PPRM:

120489747(crhr1)

RKG:

130070322

MAMB:

125272492(crhr1)

CIDE:

127509594

CERY:

137010721(crhr1)

MASI:

127450521 127451584

TROS:

130561342(crhr1)

TDW:	130426419(crhr1)

MANU:

129436378(crhr1)

PDAB:

135733922 135768517

IPU:	108261365(crhr1) 108273210

IFU:	128601414(crhr1) 128604647

PHYP:

113528562 113533697

SMEO:

124384293 124397173(crhr1)

TFD:	113638007(crhr1) 113652087

TVC:	132846419 132861067(crhr1)

CGAR:

128520366 128544960(crhr1)

NGRA:

132868754(crhr1) 132885865

TRN:	134310082 134335846(crhr1)

AMEX:

103028117(crhr1) 103036295

CMAO:

118821233(crhr1) 118822395

EEE:	113583367 113590078

CHAR:

105890724(crhr1) 105901292

SPIL:

134075819(crhr1) 134077158

TRU:

101068283

TFS:

130524985

TNG:	GSTEN00022293G001

LCO:	104935921 104938139

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:	117246796 117267801(crhr1)

EFO:	125879217(crhr1) 125880668

PLEP:

121958681

SLUC:

116035212(crhr1) 116061376

ECRA:

117937013 117941303

PFLV:

114548037(crhr1) 114568981

GAT:	120819552(crhr1)

PPUG:

119213038

AFB:	129091320 129098197(crhr1)

CLUM:

117748723(crhr1)

PSWI:

130203758

CANA:

137789797

CVE:	137884034(crhr1) 137891944

MSAM:

119896097(crhr1) 119916292

SCHU:

122867879 122869202(crhr1)

CUD:	121528747 121529141(crhr1)

SPUL:

138593317 138604145(crhr1)

LMIX:

132954295(crhr1) 132955156

ALAT:

119010188 119014761(crhr1)

ASTR:

137588763 137610291

MZE:	101467831 101481663

ONL:	100696279 100703872

OAU:	116319399(crhr1) 116321249

OLA:

101166997

OML:	112154261(crhr1)

CSAI:

133419341(crhr1)

XMA:	102221570 102235780

XCO:	114152235 114160419

XHE:	116727308 116735999

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122821832(crhr1) 122822861

PPRL:

129368025 129373706(crhr1)

CVG:	107089307 107093968

CTUL:

119775988 119781697(crhr1)

GMU:	124862392 124863919 124874700

NFU:	107387289 107395845

KMR:	108228704 108228790(crhr1)

ALIM:

106521999(crhr1) 106528103 106528106

NWH:	119421282(crhr1) 119423850

AOCE:

111568171(crhr1) 111584347

EJA:	138204646 138207715(crhr1)

BFRE:

138624354 138631371(crhr1)

MCEP:

124998300(crhr1) 125023015

CSEM:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:	108873237(crhr1) 108892057

SDU:	111220049 111239794

SLAL:

111657522 111664297

XGL:	120786345(crhr1) 120794740

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110154202(crhr1) 110170190

ENY:	140365437 140369100

MALB:

109962773 109972661

BSPL:

114845891 114860354(crhr1)

SJO:	128379402(crhr1) 128380924

SSCO:

133999376(crhr1) 134003320

GMH:	115531262(crhr1)

SASA:

106600876 106607456

STRU:

115170939 115196407

OTW:	112225893 112258497(crhr1)

OMY:	100136220(crhr1) 110486134

OGO:	124000145(crhr1) 124016118

ONE:	115104025 115110128

OKI:	109892213 109897260

OKE:	118365165 118384390(crhr1)

OMM:	135553939 135555846

OCLA:

139422143 139423892

SALP:

111979890 111981982

SNH:	120033943 120043971

CCLU:

121551688 121569718

ELS:	105023366(crhr1)

OEP:	134031629 134034073(crhr1)

SFM:	108924751 108941795

PKI:	111856013 111856802

AANG:

118216809(crhr1) 118218028

AROT:

135242967 135247848

CCOG:

133114482(crhr1)

LOC:

102695551

PSPA:

121301780(crhr1)

ARUT:

117433310 117970161

PSEX:

120517679(crhr1)

LCM:	102359764(CRHR2)

CMK:

103187736

SPU:	105440442 577102

LPIC:

129274097 129275066

ARUN:

117300004

AAMU:

139948997

AFIL:

140135437 140149891 140150862 140156307

PFLL:

139114704

DME:	Dmel_CG12370(Dh44-R2) Dmel_CG8422(Dh44-R1)

DER:	6546587 6549335

DSE:	6608855 6609139

DSI:	Dsimw501_GD10893(Dsim_GD10893) Dsimw501_GD11050(Dsim_GD11050)

DYA:	Dyak_GE12470 Dyak_GE13585

DAN:	6495367 6496342

DSR:	110180007 110189202

DPO:	4803884 4805464

DPE:	6590223 6600803

DMN:	108158227 108159235 117185733

DWI:	6640040 6646168

DGR:	6559460 6559739

DMO:	Dmoj_GI19749 Dmoj_GI20281

DAZ:	108615758 108617592

DNV:	108654863 108655198

DHE:	111593191 111600681

DVI:	6624799(Dh44-R1) 6635945(Dh44-R2)

CCAT:

101449447 101459903

BOD:	106621407 106625976

BDR:	105229170 105230520

RZE:	108365247 108368682

AOQ:	129244077 129244164

ALUD:

128866252 128866861

TDA:	119674619 119678702 119681442

MDE:

101891158

SCAC:

106088923

LCQ:	111679333 111684850

LSQ:	119606065 119615699

CVJ:	135961454(Dh44-R1) 135961844(Dh44-R2)

GFS:	119636236 119642198

ECOE:

129950326 129952620

CLON:

129610601 129613286

HIS:	119646766 119661367

AGA:	1276156 1276158

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:	5567138 5570395

AALB:

109409995 109419645 109420199

ASUA:

134208787 134208790

CQU:	CpipJ_CPIJ008821 CpipJ_CPIJ008822

CPII:

120422320 120422324

CNS:	116345773 116345912

BCOO:

119079432 119079434

LLL:	129794108 129794294

PPAP:

AME:

ACER:

ALAB:

ADR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139102273(Dh44-r1)

TLN:	139819270(Dh44-r1)

HST:

DQU:

CFO:

FEX:

PMEC:

138931992(Dh44-r1)

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124217496(Dh44-R1)

NFB:

NLO:

NVG:

AROA:

TCA:	659812(GLEAN_12799) 664316

TMOL:

DPA:

ESIM:

EFOR:

AGRG:

CSET:

HAXR:

AGB:

LDC:	111501993 111503323 111511253

DVV:	114331654 114332568

APLN:

108734192

PPYR:

116168431 116169184 116181853

OTU:	111415572 111422149

BMOR:

101743146

BMAN:

114241902

MSEX:

115452421

DPL:	KGM_214005A KGM_214005B

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

CSTB:

CFEL:

CCRN:

API:	100166470 100572659

DNX:	107166904 107166907

AGS:	114120463 114120466

RMD:	113548872 113555054

ACOO:

126842581 126847436

DVT:	126895444 126895446

BTAB:

109030914

DCI:

103511184

CLEC:

106666441 106668989

HHAL:

106680473 106682506 106684546(Dh44-R2)

NLU:	111050624 111052558

HVI:	124365959 124366199 124366279 124366476

MQU:	128995680 129002482 129002817 129003775 129004120

PHU:	Phum_PHUM132710

FOC:	113208944 113211574

TPAL:

117646203 117646269

ZNE:

110832851

CSEC:

111864021

SGRE:

126354276 126354714 126356006

BROR:

134540906

IEL:	124158978 124158979

HAMR:

139692101 139692103

FCD:	110854108 110854109

DPX:	DAPPUDRAFT_290680 DAPPUDRAFT_62157

DMK:	116918228 116918279 123470536

DPZ:	124344592 124344598

AFRA:

136039273

PJA:	122253941 122255441 122262900

PCHN:

125040370 125040468 125041929 125044905

PMOO:

119582196 119583042

HAME:

121854858 121855626 121879999

PTRU:

123508527 123513930 123514363 123518739 123519985 123519993

ESN:	126981054 126983115 126984010 126987712 126992126

MNZ:	135217334 135217565 135217715 135219286

MRJ:	136835405 136835943 136849257 136855681

PORN:

139755493 139764019 139764652

HAZT:

108679284

EAF:	111696747 111698469 111701867

LSM:	121126785(Dh44-R2) 121129724

TCF:	131881979 131882694 131887768

PPOI:

119097217 119110575

DSV:	119434486 119434568 119441003 119441568 119441573

RSAN:

119385618 119386231 119386797 119386800

RMP:	119177849 119177851 119178395

VDE:	111242811 111247711 111252529

VJA:	111263185 111264625 111265701 111267806

TUT:	107360191 107366359

DPTE:

113789684 113796876

DFR:	124491759 124500094

CSCU:

111619768 111626245

CVS:	136977560 136985954

PTEP:

107438883 107442483 107452238 107454414 107454507 107454966

ABRU:

129965694 129966168 129968211 129968618 129968964 129969582 129980643 129987622

UDV:	129216465 129219845 129220581 129221141 129221384 129223182 129228461 129228551 129228582 129229934 129230724 129234271

SDM:	118181751 118181820 118184571 118192364 118192468 118192849 118194085 118195921 118199505

LPOL:

106457043 106457542 106457543 106458443 106460107 106460299 106464558 106466149 106473027 106474995 106475300 106478462

PMEO:

129594267 129598669 129599838

CEL:	CELE_C18B12.2(seb-3)

CBR:

CBG_07642

CRQ:	GCK72_025596

PCAN:

112563614 112564446 112565107

LSAX:

138982599

BGT:

106050310

GAE:

121381627

CRG:	105337403 105348646

DPOL:

OBI:

OSN:

LJP:

LAK:

NVE:	116612680 5500693 5514687

EPA:	110233123 110249072

ADF:	107328346 107333074

PDAM:

113668401 113668403 113674190 113679685 113684118

SPIS:

111319304 111335166 111335333 111336674 111337040 111340424 111345025 111345378 111346143

XEN:	124440317 124440320

HSY:

130621659

» show all

Reference

PMID:7692441

Authors

Chen R, Lewis KA, Perrin MH, Vale WW

Title

Expression cloning of a human corticotropin-releasing-factor receptor.

Journal

Proc Natl Acad Sci U S A 90:8967-71 (1993)
DOI:10.1073/pnas.90.19.8967

Sequence

[hsa:1394]

LinkDB

DBGET integrated database retrieval system