KEGG   ORTHOLOGY: K04633
Entry
K04633                      KO                                     
Symbol
GNAL
Name
guanine nucleotide-binding protein G(olf) subunit alpha
Pathway
map04020  Calcium signaling pathway
map04082  Neuroactive ligand signaling
map04728  Dopaminergic synapse
map04740  Olfactory transduction
map05012  Parkinson disease
map05142  Chagas disease
map05146  Amoebiasis
Disease
H00831  Primary dystonia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
  09157 Sensory system
   04740 Olfactory transduction
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
   05142 Chagas disease
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 2 (Gs)
    K04633  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha
Genes
HSA: 2774(GNAL)
PTR: 455285(GNAL)
PPS: 100975164(GNAL)
GGO: 101129289(GNAL)
PON: 100453901(GNAL)
PPYG: 129018752(GNAL)
NLE: 100597944(GNAL)
HMH: 116468756(GNAL)
SSYN: 129460585(GNAL)
MCC: 114673806(GNAL)
MCF: 102137826(GNAL)
MTHB: 126941120
MNI: 105478963(GNAL)
CSAB: 103222785(GNAL)
CATY: 105579393(GNAL)
PANU: 101018186(GNAL)
TGE: 112611291(GNAL)
MLEU: 105542395(GNAL)
RRO: 104670245(GNAL)
RBB: 108527485(GNAL)
TFN: 117064164(GNAL)
PTEH: 111553605(GNAL)
CANG: 105507936(GNAL)
CJC: 100387535(GNAL)
SBQ: 101050072(GNAL)
CIMI: 108282501(GNAL)
ANAN: 105729374(GNAL)
CSYR: 103261507(GNAL)
MMUR: 105860951(GNAL)
LCAT: 123621827(GNAL)
PCOQ: 105814872(GNAL)
OGA: 100965453(GNAL)
MMU: 14680(Gnal)
MCAL: 110284817(Gnal)
MPAH: 110332897(Gnal)
RNO: 24611(Gnal)
MCOC: 116087292(Gnal)
ANU: 117720109(Gnal)
ASYL: 127663559(Gnal)
MUN: 110562438(Gnal)
CGE: 100760304(Gnal)
MAUA: 101826012(Gnal)
PROB: 127234079(Gnal)
PLEU: 114682360(Gnal)
MORG: 121438780(Gnal)
MFOT: 126511046
AAMP: 119814407(Gnal)
NGI: 103735431(Gnal)
HGL: 101718578(Gnal)
CPOC: 100716796(Gnal)
CCAN: 109696090(Gnal)
DSP: 122110945(Gnal)
PLOP: 125364003(Gnal)
NCAR: 124965701
MMMA: 107159455(Gnal)
ITI: 101971840(Gnal)
OCU: 100348829
OPI: 101525095(GNAL)
TUP: 102478287(GNAL)
GVR: 103603516(GNAL)
CFA: 607658(GNAL)
CLUD: 112648092(GNAL)
VVP: 112925297(GNAL)
VLG: 121489223(GNAL)
NPO: 129508633(GNAL)
AML: 100479878(GNAL)
UMR: 103673377(GNAL)
UAH: 113245925(GNAL)
UAR: 123803557(GNAL)
ELK: 111142441
LLV: 125081981
MPUF: 101687077(GNAL)
MNP: 132023466(GNAL)
MLK: 131810915(GNAL)
NVS: 122903126(GNAL)
ORO: 101380718(GNAL)
EJU: 114198071(GNAL)
ZCA: 113912327(GNAL)
MLX: 118026436(GNAL)
NSU: 110574339(GNAL)
LWW: 102738541
FCA: 101098171(GNAL)
PYU: 121033198(GNAL)
PCOO: 112868351(GNAL)
PBG: 122470544(GNAL)
PVIV: 125148870(GNAL)
LRUF: 124519777
LGF: 123588367(GNAL)
AJU: 106981474
PTG: 102952450(GNAL)
PPAD: 109257624(GNAL)
PUC: 125914842
PLEZ: 122204274(GNAL)
HHV: 120220192(GNAL)
BTA: 100124520(GNAL)
BOM: 102272478(GNAL)
BIU: 109577812(GNAL)
BBUB: 102394701(GNAL)
BBIS: 105002480(GNAL)
CHX: 100861281(GNAL)
OAS: 101105461(GNAL)
BTAX: 128067338(GNAL)
CSUM: 138097513(GNAL)
ODA: 120862548 120880820(GNAL)
CCAD: 122425491(GNAL)
MREE: 136166418(GNAL)
OVR: 110150682(GNAL)
MBEZ: 129549795(GNAL)
SSC: 100736677(GNAL)
CFR: 102508705(GNAL)
CBAI: 105071436(GNAL)
CDK: 105086482(GNAL)
VPC: 102536691(GNAL)
BACU: 102997876(GNAL)
BMUS: 118880118(GNAL)
LVE: 103070661(GNAL)
OOR: 101276531(GNAL)
LALB: 132504525(GNAL)
DLE: 111162870(GNAL)
PCAD: 102997025 114483879
PSIU: 116765114(GNAL)
NASI: 112412304(GNAL)
ECB: 100050622(GNAL)
EPZ: 103540366(GNAL)
EAI: 106823408(GNAL)
MYB: 102263508(GNAL)
MYD: 102759466(GNAL)
MMYO: 118662539(GNAL)
MLF: 102428060(GNAL)
MDT: 132239795(GNAL)
MYUM: 139014027(GNAL)
PKL: 118707514(GNAL)
EFUS: 103302698(GNAL)
MNA: 107533994(GNAL)
DRO: 112322569(GNAL)
SHON: 119001973(GNAL)
AJM: 119051300(GNAL)
PDIC: 114506842(GNAL)
PHAS: 123826403(GNAL)
MMF: 118618219(GNAL) 118627279
PPAM: 129081669(GNAL)
HAI: 109373565(GNAL)
RFQ: 117038743(GNAL)
PALE: 102886226(GNAL)
PGIG: 120588796(GNAL)
PVP: 105306348(GNAL)
RAY: 107497716(GNAL)
MJV: 108405272(GNAL)
TOD: 119243201(GNAL)
SARA: 101538288(GNAL)
SFUM: 130045161(GNAL)
SETR: 126003743(GNAL)
LAV: 100665771(GNAL)
TMU: 101346169
DNM: 101426937(GNAL)
MDO: 100013751(GNAL)
GAS: 123239631(GNAL)
SHR: 100931638(GNAL)
AFZ: 127544031
PCW: 110207788(GNAL)
TVP: 118845734(GNAL)
PBRV: 138170359(GNAL)
OAA: 100077658(GNAL)
TACU: 119928455(GNAL)
GGA: 474379(GNAL)
PCOC: 116226210(GNAL)
MGP: 100546747(GNAL)
CJO: 107310002(GNAL)
TPAI: 128091460(GNAL)
LMUT: 125690613(GNAL)
NMEL: 110394740(GNAL)
APLA: 101803485(GNAL)
ACYG: 106034938(GNAL)
CATA: 118257417(GNAL)
AFUL: 116486318(GNAL)
TGU: 100219216(GNAL)
LSR: 110469231(GNAL)
SCAN: 103826629(GNAL)
PMOA: 120500711(GNAL)
OTC: 121333235(GNAL)
PRUF: 121358971(GNAL)
ATRC: 139605439(GNAL)
GFR: 102045470(GNAL)
FAB: 101813676(GNAL)
OMA: 130249032(GNAL)
PHI: 102107758(GNAL)
PMAJ: 107199749(GNAL)
CCAE: 111924987(GNAL)
CCW: 104687270(GNAL)
CBRC: 103612425(GNAL)
ACOE: 138104975(GNAL)
ETL: 114065518(GNAL)
ZAB: 102066011(GNAL)
ZLE: 135444336(GNAL)
ACHL: 103801156(GNAL)
SVG: 106849928(GNAL)
MMEA: 130575196(GNAL)
HRT: 120752129(GNAL)
SATI: 136375482(GNAL)
CCIC: 134041344(GNAL)
FPG: 101914068(GNAL)
FCH: 102055293(GNAL)
CCRI: 104167375(GNAL)
SHAB: 115610350(GNAL)
ACUN: 113476214(GNAL)
TALA: 104364467(GNAL)
ACHC: 115340477(GNAL)
HALD: 104315478(GNAL)
HLE: 104841569(GNAL)
AGEN: 126051274
HHAR: 128141921(GNAL)
GCL: 127013768
LDI: 104345462(GNAL)
DPUB: 104308700(GNAL)
PPUS: 135178877(GNAL)
AVIT: 104271575(GNAL)
EGZ: 104132886(GNAL)
NNI: 104017660(GNAL)
PCRI: 104038928
PADL: 103912281(GNAL)
AFOR: 103903004(GNAL)
FGA: 104082680(GNAL)
GSTE: 104261566(GNAL)
CLV: 102096038(GNAL)
MUI: 104543525
PGUU: 104467824(GNAL)
EHS: 104510427
CUCA: 104065506(GNAL)
TEO: 104373979(GNAL)
BREG: 104640703(GNAL)
ACAR: 104528681(GNAL)
CPEA: 104396961(GNAL)
CVF: 104290021(GNAL)
RTD: 128905560(GNAL)
CRID: 134511869(GNAL)
AAM: 106484403(GNAL)
AROW: 112964661(GNAL)
NPD: 112942828(GNAL)
TGT: 104574017(GNAL)
DNE: 112979852(GNAL)
SCAM: 104151304(GNAL)
ASN: 102370678(GNAL)
AMJ: 106737002(GNAL)
CPOO: 109317242(GNAL)
GGN: 109303130(GNAL)
PSS: 102454123(GNAL)
CMY: 102943864(GNAL)
CCAY: 125632296(GNAL)
DCC: 119851793(GNAL)
CPIC: 101953562(GNAL)
TST: 117873339(GNAL)
CABI: 116830171(GNAL)
MRV: 120398919(GNAL)
ASAO: 132774711(GNAL)
PVT: 110078908(GNAL)
SUND: 121927794(GNAL)
PBI: 103059175(GNAL)
PMUR: 107294911(GNAL)
CTIG: 120306278(GNAL)
TSR: 106551129(GNAL)
PGUT: 117672628(GNAL)
APRI: 131194341(GNAL)
PTEX: 113435522(GNAL)
NSS: 113414844(GNAL)
VKO: 123021582(GNAL)
PMUA: 114600754(GNAL)
PRAF: 128417624(GNAL)
ZVI: 118089792(GNAL)
HCG: 128324315(GNAL)
GJA: 107113095(GNAL)
STOW: 125438735(GNAL)
EMC: 129333159(GNAL)
XLA: 378630(gnal.S) 443714(gnal.L)
XTR: 100216229(gnal)
NPR: 108787315(GNAL) 108798434
RTEM: 120940859(GNAL)
BBUF: 121002196(GNAL)
BGAR: 122938258(GNAL)
PWL: 138282340(GNAL)
MUO: 115476101(GNAL)
GSH: 117355473(GNAL)
DRE: 407724(gnal2) 492467(gnal)
SRX: 107717546 107726148 107732066
SANH: 107667176 107677176 107702493
SGH: 107554377 107568974 107570731(gnal) 107599686
CCAR: 109049202 109079578 109079579 109108100(gnal)
CAUA: 113042594 113092761 113100663
CGIB: 127945935 127946379 128013250
PTET: 122329502(gnal) 122329756
LROH: 127155680(gnal) 127155720(gnal2)
OMC: 131532879(gnal) 131532999
PPRM: 120482774 120488089(gnal2)
RKG: 130070373(gnal) 130084151
MAMB: 125258238(gnal) 125258359
CIDE: 127506210 127506341
CERY: 137013838(gnal) 137014163
MASI: 127431567 127432187 127434103 127434434
TROS: 130546683 130546811(gnal)
TDW: 130413025(gnal) 130413180
MANU: 129425590 129425594 129426492(gnal2)
PDAB: 135740379(gnal2) 135777766
IPU: 108256214 108262790(gnal2)
IFU: 128599885(gnal) 128624553(gnal2)
PHYP: 113533040(gnal) 113533810
SMEO: 124375332(gnal) 124384899
TFD: 113648597(gnal2) 113659700(gnal)
TVC: 132840522(gnal) 132846360(gnal2)
CGAR: 128514106(gnal) 128520132(gnal2)
NGRA: 132867275(gnal) 132886411(gnal2)
TRN: 134301178(gnal)
AMEX: 103027767(gnal) 103040890
CMAO: 118800439(gnal) 118822975
EEE: 113581643 113582412(gnal)
CHAR: 105893781 122130722
SPIL: 134065760(gnal)
TRU: 101066394 101077363(gnal)
TFS: 130514149 130538550(gnal)
TNG: GSTEN00007449G001 GSTEN00027664G001
LCO: 104936418(gnal) 104939455
NCC: 104950919 104963064
TBEN: 117470681 117500268(gnal)
CGOB: 115022628(gnal)
PGEO: 117462139
GACU: 117540859(gnal)
EMAC: 134865796(gnal) 134883753
ELY: 117265048 117272153
EFO: 125882000 125902096
PLEP: 121939789 121951430
SLUC: 116045838 116067079
ECRA: 117954356
ESP: 116698856(gnal)
PFLV: 114564873(gnal)
GAT: 120811607 120816039
PPUG: 119198591 119208791
AFB: 129089387 129110705
CLUM: 117746160 117749484
PSWI: 130197576(gnal) 130206588
CANA: 137779456 137788519(gnal)
CVE: 137892166 137892539
MSAM: 119897676 119901803
SCHU: 122886560
CUD: 121520666 121527276
SPUL: 138595737 138611408
LMIX: 132965600 132979404
ALAT: 119008535 119011050
ASTR: 137587496 137611807
MZE: 101474191 101482928(gnal)
ONL: 100709658 100710773(gnal)
OAU: 116313363(gnal) 116330605
OLA: 101161386 101174132(gnal)
OML: 112152221(gnal) 118597866
CSAI: 133423541 133452462(gnal)
XMA: 102227168(gnal) 102232671
XCO: 114137224 114146105(gnal)
XHE: 116712312 116721319(gnal)
PRET: 103460154 103479907(gnal)
PFOR: 103148564 103154855
PLAI: 106936119 106939286
PMEI: 106906695 106930948(gnal)
GAF: 122824443 122840936
PPRL: 129356761 129378015
CVG: 107095436 107100929
CTUL: 119775376 119787877
GMU: 124857986 124869490(gnal)
NFU: 107383531(gnal) 107396846
KMR: 108232917 108251585
ALIM: 106520735 106537305
NWH: 119415228(gnal2)
AOCE: 111567001 111586146
EJA: 138203202 138215416
BFRE: 138617457 138633783
MCEP: 124995471 125010400
CSEM: 103377324 103396682
POV: 109643287 109646811
SSEN: 122772474 122781178
SSOE: 131458930 131468048
HHIP: 117754091 117777652(gnal)
HSP: 118098585 118117547(gnal)
PPLT: 128425773 128454268
SMAU: 118291426 118311710(gnal)
LCF: 108884251 108890118
SDU: 111231069(gnal) 111236865
SLAL: 111645039 111658409(gnal) 111664870
XGL: 120790220 120798454(gnal)
HCQ: 109524101(gnal) 109526311
SSCV: 125985353 125985800
SBIA: 133492729 133510522
PEE: 133396369 133411382
PTAO: 133470374 133489532
BPEC: 110173238 110174910(gnal)
ENY: 140356002(gnal2)
MALB: 109955280(gnal) 109974964
BSPL: 114844805 114853974(gnal)
SJO: 128368834 128382142
SSCO: 133977266 133991275
GMH: 115537729 115549673(gnal)
SASA: 106569655 106579638 106590334 106596430 106596458
STRU: 115150015 115170218 115195582
OTW: 112215312 112227790(gnal) 112236241 112247728
OMY: 110489752(gnal) 110508251 110530889 110535248
OGO: 123991387 124039629(gnal) 124042193
ONE: 115104869 115130208
OKI: 109884856 109886088 109899328 109909794
OKE: 118361199 118371082(gnal) 118378035
OMM: 135517318(gnal) 135522901 135558323
OCLA: 139367037 139375794 139387577 139420185
SALP: 111953575 111972774
SNH: 120027732 120051037
CCLU: 121535714 121549676 121569170 123481051
ELS: 105019515 105030514
OEP: 134034617 134036053
SFM: 108927555 108930092(gnal)
PKI: 111840799 111851408(gnal)
AANG: 118226258(gnal) 118233743
AROT: 135252739(gnal) 135260984
CCOG: 133126539(gnal) 133137082
LOC: 102682577(gnal)
PSPA: 121313518 121313520 121314459(gnal)
ARUT: 117394828(gnal) 117399688 117400471 117972217
PSEX: 120530340(gnal)
LCM: 102351759(GNAL)
CMK: 103172506
RTP: 109910513
CPLA: 122548864
HOC: 132815099
LERI: 129696467
LPIC: 129276510 129276514 129278597
AJJ: 139975628
AJC: 117100003
CSEC: 111864972
PJA: 122256806
HAME: 121865900
PCLA: 123746318
PTRU: 123510218
ESN: 126996129
HAZT: 108670569
TCF: 131881164
DFR: 124496186
UDV: 129220428
SDM: 118184836
PVUL: 126821404
BGT: 106072828
GAE: 121385547
HRF: 124151448
CRG: 105337340 105337345
CANU: 128162850 128191445 128191454
CVN: 111108814 111134379 111134389
DPOL: 127860469 127860470
OSN: 115228513
LJP: 135471886
LLON: 135498020
HSY: 130662816
 » show all
Reference
PMID:8243272
  Authors
Zigman JM, Westermark GT, LaMendola J, Boel E, Steiner DF
  Title
Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and  central nervous system.
  Journal
Endocrinology 133:2508-14 (1993)
DOI:10.1210/endo.133.6.8243272
  Sequence
[hsa:2774]
Reference
PMID:16183910
  Authors
Wettschureck N, Offermanns S.
  Title
Mammalian G proteins and their cell type specific functions.
  Journal
Physiol Rev 85:1159-204 (2005)
DOI:10.1152/physrev.00003.2005
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