KEGG ORTHOLOGY: K04697

ORTHOLOGY: K04697

Entry

K04697                      KO

Symbol

SOCS4

Name

suppressor of cytokine signaling 4

Pathway

map04630

JAK-STAT signaling pathway

map04910

Insulin signaling pathway

map04917

Prolactin signaling pathway

map04930

Type II diabetes mellitus

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K04697  SOCS4; suppressor of cytokine signaling 4
09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04697  SOCS4; suppressor of cytokine signaling 4
   04917 Prolactin signaling pathway
    K04697  SOCS4; suppressor of cytokine signaling 4
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04697  SOCS4; suppressor of cytokine signaling 4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K04697  SOCS4; suppressor of cytokine signaling 4
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul5 complex
    Target recognizing subunit
     K04697  SOCS4; suppressor of cytokine signaling 4

Genes

HSA:	122809(SOCS4)

PTR:	452919(SOCS4)

PPS:	100989690(SOCS4)

GGO:	101131192(SOCS4)

PON:	100171842(SOCS4)

PPYG:

129012622(SOCS4)

NLE:	100590972(SOCS4)

HMH:	116456249(SOCS4)

SSYN:

129487862(SOCS4)

MCC:	696146(SOCS4)

MCF:	102141350(SOCS4)

MTHB:

126959337

MNI:	105481786(SOCS4)

CSAB:

103229025(SOCS4)

CATY:

105586646(SOCS4)

PANU:

100997112(SOCS4)

TGE:	112628778(SOCS4)

MLEU:

105553584(SOCS4)

RRO:	104669147(SOCS4)

RBB:	108530661(SOCS4)

TFN:	117069613(SOCS4)

CANG:

105525994(SOCS4)

CJC:	100386210(SOCS4)

SBQ:	101034850(SOCS4)

CIMI:

108294062(SOCS4)

ANAN:

105716401(SOCS4)

CSYR:

103250822(SOCS4)

MMUR:

105867701(SOCS4)

LCAT:

123648892(SOCS4)

PCOQ:

105825865(SOCS4)

OGA:	100957947(SOCS4)

MMU:	67296(Socs4)

MCAL:

110309072(Socs4)

MPAH:

110325522(Socs4)

RNO:	305828(Socs4)

MCOC:

116085200(Socs4)

ANU:	117705978(Socs4)

ASYL:

127691682(Socs4)

MUN:	110550951(Socs4)

CGE:	100750379(Socs4)

MAUA:

101830742(Socs4)

PROB:

127216418(Socs4)

PLEU:

114696036(Socs4)

MORG:

121435011(Socs4)

MFOT:

126513827

AAMP:

119800354(Socs4)

NGI:	103739222(Socs4)

HGL:	101704725(Socs4)

CPOC:

100735753(Socs4)

CCAN:

109693954(Socs4)

DORD:

105982639(Socs4)

DSP:	122110084(Socs4)

PLOP:

125363645(Socs4)

NCAR:

124976869 124980800

MMMA:

107138292(Socs4)

ITI:	101963360(Socs4)

OCU:

100357417

OPI:	101534372(SOCS4)

TUP:	102468675(SOCS4)

CFA:	100687271(SOCS4)

CLUD:

112656872(SOCS4)

VVP:	112921409(SOCS4)

VLG:	121493618(SOCS4)

NPO:	129495910(SOCS4)

AML:	100464791(SOCS4)

UMR:	103673077(SOCS4)

UAH:	113242351(SOCS4)

UAR:	123800746(SOCS4)

ELK:

111140665

LLV:

125103821

MPUF:

101673021(SOCS4)

MNP:	131999965(SOCS4)

MLK:	131836594(SOCS4)

NVS:	122893081(SOCS4)

ORO:	101383881(SOCS4)

EJU:	114207489(SOCS4)

ZCA:	113909623(SOCS4)

MLX:	118002023(SOCS4)

NSU:	110590590(SOCS4)

LWW:	102737585(SOCS4)

FCA:	101080974(SOCS4)

PYU:	121031795(SOCS4)

PCOO:

112856019(SOCS4)

PBG:	122469118(SOCS4)

PVIV:

125167747(SOCS4)

LRUF:

124512171

LGF:	123583866(SOCS4)

AJU:

106984332

PTG:	102971697(SOCS4)

PPAD:

109268440(SOCS4)

PUC:

125909485

PLEZ:

122222731(SOCS4)

HHV:	120237265(SOCS4)

BTA:	540412(SOCS4)

BOM:	102270424(SOCS4)

BIU:	109565183(SOCS4)

BBUB:

102391689(SOCS4)

BBIS:

104994214(SOCS4)

CHX:	102185842(SOCS4)

OAS:	101117935(SOCS4)

BTAX:

128053868(SOCS4)

CSUM:

138073864(SOCS4)

ODA:	120852914(SOCS4)

CCAD:

122443672(SOCS4)

MREE:

136171457(SOCS4)

OVR:	110130836(SOCS4)

MBEZ:

129562912(SOCS4)

SSC:	100302366(SOCS4)

CFR:	102515584(SOCS4)

CBAI:

105074596(SOCS4)

CDK:	105091440(SOCS4)

VPC:	102532736(SOCS4)

BACU:

103014060(SOCS4)

BMUS:

118890695(SOCS4)

LVE:	103076129(SOCS4)

OOR:	101275711(SOCS4)

LALB:

132515917(SOCS4)

DLE:	111173136(SOCS4)

PCAD:

102993244(SOCS4)

PSIU:

116749322(SOCS4)

NASI:

112392871(SOCS4)

ECB:	100050301(SOCS4)

EPZ:	103554102(SOCS4)

EAI:	106846111(SOCS4)

MYB:	102247430(SOCS4)

MYD:	102767035(SOCS4)

MMYO:

118655678(SOCS4)

MLF:	102434218(SOCS4)

MDT:	132234237(SOCS4)

MYUM:

139013171(SOCS4)

PKL:	118717809(SOCS4)

EFUS:

103283718(SOCS4)

MNA:	107525887(SOCS4)

DRO:	112311535(SOCS4)

SHON:

118992421(SOCS4)

AJM:	119057045(SOCS4)

PDIC:

114491820(SOCS4)

PHAS:

123808769(SOCS4)

MMF:	118616174(SOCS4)

PPAM:

129066016(SOCS4)

HAI:	109384171(SOCS4)

RFQ:	117023555(SOCS4)

PALE:

102879275(SOCS4)

PGIG:

120605611(SOCS4)

PVP:	105309162(SOCS4)

RAY:	107503961(SOCS4)

MJV:	108396005(SOCS4)

TOD:	119239113(SOCS4)

SARA:

101542642(SOCS4)

SFUM:

130041128(SOCS4)

SETR:

125999239(SOCS4)

LAV:	100662743(SOCS4)

TMU:

101358025

ETF:	101656743(SOCS4)

DNM:	101435282(SOCS4)

MDO:	100024207(SOCS4)

GAS:	123235771(SOCS4)

SHR:	100921040(SOCS4)

AFZ:

127549779

PCW:	110211768(SOCS4)

TVP:	118840977(SOCS4)

PBRV:

138156857(SOCS4)

OAA:	100086717(SOCS4)

TACU:

119936836(SOCS4)

GGA:	423557(SOCS4)

PCOC:

116236655(SOCS4)

MGP:	100549827(SOCS4)

CJO:	107315453(SOCS4)

TPAI:

128087214(SOCS4)

LMUT:

125695087(SOCS4)

NMEL:

110401367(SOCS4)

APLA:

101804231(SOCS4)

ACYG:

106044059(SOCS4)

CATA:

118250253(SOCS4)

AFUL:

116490340(SOCS4)

TGU:	100230629(SOCS4)

LSR:	110472710(SOCS4)

SCAN:

103826330(SOCS4)

PMOA:

120503863(SOCS4)

OTC:	121340694(SOCS4)

PRUF:

121358540(SOCS4)

ATRC:

139589639(SOCS4)

GFR:	102043937(SOCS4)

FAB:	101815072(SOCS4) 101816294

OMA:	130253427(SOCS4)

PHI:	102109006(SOCS4)

PMAJ:

107206463(SOCS4)

CCAE:

111929669(SOCS4)

CCW:	104687619(SOCS4)

CBRC:

103618842(SOCS4)

ACOE:

138110930(SOCS4)

ETL:	114069886(SOCS4)

ZAB:	102065785(SOCS4)

ZLE:	135448397(SOCS4)

ACHL:

103805619(SOCS4)

SVG:	106850254(SOCS4)

MMEA:

130584961(SOCS4)

HRT:	120754154(SOCS4)

SATI:

136362748(SOCS4)

CCIC:

134045689(SOCS4)

FPG:	101924304(SOCS4)

FCH:	102048310(SOCS4)

CCRI:

104167126(SOCS4)

NNT:	104401344(SOCS4)

SHAB:

115607443(SOCS4)

ACUN:

113480674(SOCS4)

TALA:

104361742(SOCS4)

ACHC:

115353378(SOCS4)

HALD:

104312682(SOCS4)

HLE:	104839489(SOCS4)

AGEN:

126050565

HHAR:

128140116(SOCS4)

GCL:

127016739

CSTI:

104555949(SOCS4)

LDI:	104349955(SOCS4)

MNB:	103768848(SOCS4)

DPUB:

104307240(SOCS4)

PPUS:

135180264(SOCS4)

AVIT:

104269693(SOCS4)

BRHI:

104500036(SOCS4)

EGZ:	104122986(SOCS4)

NNI:	104019434(SOCS4)

PCRI:

104039047(SOCS4)

PCAO:

104043718(SOCS4)

PADL:

103915976(SOCS4)

AFOR:

103907623(SOCS4)

FGA:	104081754(SOCS4)

GSTE:

104255375(SOCS4)

CLV:	102086690(SOCS4)

MUI:	104536452(SOCS4)

PGUU:

104460665(SOCS4)

PLET:

104621798(SOCS4)

EHS:	104505354(SOCS4)

CMAC:

104477539(SOCS4)

CUCA:

104057434(SOCS4)

TEO:	104371467(SOCS4)

BREG:

104633176(SOCS4)

OHA:	104333953(SOCS4)

ACAR:

104529520(SOCS4)

CPEA:

104387672(SOCS4)

CVF:	104294316(SOCS4)

RTD:	128908915(SOCS4)

CRID:

134514825(SOCS4)

AAM:	106493674(SOCS4)

AROW:

112961262(SOCS4)

NPD:	112957813(SOCS4)

TGT:	104578206(SOCS4)

DNE:	112983142(SOCS4)

SCAM:

104141372(SOCS4)

ASN:	102384587(SOCS4)

AMJ:	102572731(SOCS4)

CPOO:

109320721(SOCS4)

GGN:	109298315(SOCS4)

PSS:	102453072(SOCS4)

CMY:	102931468(SOCS4)

CCAY:

125638339(SOCS4)

DCC:	119857675(SOCS4)

CPIC:

101953043(SOCS4)

TST:	117876943(SOCS4)

CABI:

116819030(SOCS4)

MRV:	120403702(SOCS4)

ACS:	100561266(socs4)

ASAO:

132760993(SOCS4)

PVT:	110070093(SOCS4)

SUND:

121922070(SOCS4)

PBI:	103053679(SOCS4)

PMUR:

107293655(SOCS4)

CTIG:

120297959(SOCS4)

TSR:	106539854(SOCS4)

PGUT:

117675093(SOCS4)

APRI:

131188064(SOCS4)

PTEX:

113435115(SOCS4)

NSS:	113413735(SOCS4)

VKO:	123026799(SOCS4)

PMUA:

114595944(SOCS4)

PRAF:

128414803(SOCS4)

ZVI:	118078072(SOCS4)

HCG:	128334756(SOCS4)

GJA:	107113082(SOCS4)

STOW:

125427025(SOCS4)

EMC:	129323632(SOCS4)

XLA:	108698764(socs4.L) 108699788(socs4.S)

XTR:	549828(socs4)

NPR:	108789412(SOCS4)

RTEM:

120920275(SOCS4)

BGAR:

122922230 122924947(SOCS4)

MUO:	115477844(SOCS4)

DRE:	797891(socs4)

SRX:	107723705 107751808

SANH:

107680769 107693087

SGH:	107564995 107583461

CCAR:

109106892 109106893

CAUA:

113060347 113069470

CGIB:

127933545 127976658

PTET:

122362354(socs4)

LROH:

127179264(socs4)

OMC:	131523508(socs4)

PPRM:

120490736(socs4)

RKG:	130101469(socs4)

MAMB:

125268470(socs4)

CIDE:

127498652

CERY:

137007007(socs4)

MASI:

127455442

TROS:

130560666(socs4)

TDW:	130437250(socs4)

MANU:

129417311(socs4)

PDAB:

135727326 135730879

IPU:	108270091(socs4)

IFU:	128613215(socs4)

PHYP:

113534177

SMEO:

124390435(socs4)

TFD:	113651284(socs4)

TVC:	132852304(socs4)

CGAR:

128536192(socs4)

NGRA:

132893785(socs4)

TRN:	134325586(socs4)

AMEX:

103045167(socs4)

CMAO:

118823970(socs4)

EEE:

113571142

CHAR:

105896403(socs4)

SPIL:

134068082(socs4)

TRU:	100144313(socs4)

TFS:	130521710(socs4)

TNG:	GSTEN00003045G001

LCO:

104929608

NCC:

104964293

TBEN:

117471818(socs4)

CGOB:

115006088(socs4)

PGEO:

117441303(socs4)

GACU:

117533674(socs4)

EMAC:

134863738(socs4)

ELY:	117259021(socs4)

EFO:	125903782(socs4)

PLEP:

121946374(socs4)

SLUC:

116067324(socs4)

ECRA:

117939807(socs4)

ESP:

116693718

PFLV:

114561322

GAT:	100190867(socs4)

PPUG:

119194767(socs4)

AFB:	129108235(socs4)

CLUM:

117728837(socs4)

PSWI:

130193026(socs4)

CANA:

137784837(socs4)

CVE:	137882196(socs4)

MSAM:

119889719(socs4)

SCHU:

122886467(socs4)

CUD:	121513955(socs4)

SPUL:

138592623(socs4)

LMIX:

132989470(socs4)

ALAT:

119018475(socs4)

ASTR:

137598857(socs4)

MZE:

101469365

ONL:	100699329(socs4)

OAU:	116317537(socs4)

OLA:	100144385(socs4)

OML:	112138625(socs4)

CSAI:

133458339(socs4)

XMA:

XCO:

XHE:

PRET:

PFOR:

103142650(socs4)

PLAI:

106935381

PMEI:

106911193

GAF:	122845218(socs4)

CVG:	107083884(socs4)

CTUL:

119772742(socs4)

GMU:	124867350(socs4)

NFU:

107381831

KMR:	108242119(socs4)

ALIM:

106524719(socs4)

NWH:	119430261(socs4)

AOCE:

111575116(socs4)

EJA:	138208013(socs4)

BFRE:

138624896(socs4)

MCEP:

125005588(socs4)

CSEM:

103398397

POV:

109637204

SSEN:

122772123(socs4)

SSOE:

131459220(socs4)

HHIP:

117752018(socs4)

HSP:	118110616(socs4)

PPLT:

128442696(socs4)

SMAU:

118302850(socs4)

LCF:

108888048

SDU:

111224920

SLAL:

111654712(socs4)

XGL:	120794450(socs4)

HCQ:

109514287

SSCV:

125967251(socs4)

MALB:

109974789

BSPL:

114851973(socs4)

SJO:	128354946(socs4)

SSCO:

133980104(socs4)

GMH:

115559320

SASA:

106602930(socs4)

STRU:

115162742 115172108

OTW:	112246774 112257113

OMY:	110498687 110504313

OGO:	124001194(socs4) 124045198

ONE:	115138920 115146579

OKI:

109903142

OKE:	118362067 118369284

OMM:

135527005

OCLA:

139374439 139383945

SALP:

112068333 112068776 112080246

SNH:	120023069 120059963(socs4)

CCLU:

121539653(socs4)

ELS:

105023278

OEP:	134007375(socs4)

SFM:

108919519

AANG:

118232019(socs4)

AROT:

135247604(socs4)

CCOG:

133130394(socs4)

LOC:	102683522(socs4)

PSPA:

121324308 121330241

ARUT:

117422193 117963891

PSEX:

120518961(socs4)

LCM:	102362805(SOCS4)

CMK:

RTP:

CPLA:

HOC:

LERI:

EAF:

PPOI:

BGT:

HRF:

HRJ:

HASI:

OED:

AIRR:

RPHI:

EPA:

ATEN:

MCAZ:

MFOO:

DGT:

XEN:

Reference

PMID:12076535

Authors

Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.

Title

The SOCS box: a tale of destruction and degradation.

Journal

Trends Biochem Sci 27:235-41 (2002)
DOI:10.1016/S0968-0004(02)02085-6

Sequence

[hsa:122809]

Reference

PMID:15590694

Authors

Kario E, Marmor MD, Adamsky K, Citri A, Amit I, Amariglio N, Rechavi G, Yarden Y

Title

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.

Journal

J Biol Chem 280:7038-48 (2005)
DOI:10.1074/jbc.M408575200

Sequence

[hsa:122809]

LinkDB

DBGET integrated database retrieval system